公开(公告)号：EP1851166A2

公开(公告)日：2007-11-07

申请号：EP06848763.6

申请日：2006-01-11

申请人： New York University ,  HARVARD UNIVERSITY

发明人： GRIER, David, G. ,  AGARWAL, Ritesh ,  YU, Guihua ,  LIEBER, Charles, M. ,  LADAVAC, Kosta

IPC分类号： B82B3/00

CPC分类号： B82B3/00 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  C23C14/3407 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2210/30 ,  H01J37/3423 ,  H01L51/0002 ,  H01L51/0048 ,  H01L51/0052

摘要： A system and method for manipulating and processing nanowires in solution with arrays of holographic optical traps. The system and method of the present invention is capable of creating hundreds of individually controlled optical traps with the ability to manipulate objects in three dimensions. Individual nanowires with cross-sections as small as 20 nm and lengths exceeding 20 µm are capable of being isolated, translated, rotated and deposited onto a substrate with holographic optical trap arrays under conditions where single traps have no discernible influence. Spatially localized photothermal and photochemical processes induced by the well-focused traps can also be used to melt localized domains on individual nanowires and to fuse nanowire junctions.

公开(公告)号：EP1784754A2

公开(公告)日：2007-05-16

申请号：EP05785616.3

申请日：2005-08-12

申请人： HARVARD UNIVERSITY ,  Meller, Amit ,  Mathe, Jerome ,  Eid, John S.

发明人： MELLER, Amit ,  MATHE, Jerome ,  EID, John S.

IPC分类号： G06F19/00

CPC分类号： C12Q1/6827 ,  C12Q1/6869 ,  G01N33/48721 ,  Y10T436/14 ,  Y10T436/142222 ,  Y10T436/143333 ,  C12Q2565/631 ,  C12Q2535/131 ,  C12Q2525/301

摘要： Described herein are methods for analyzing polymer molecules. These methods are employed for the high throughput readout of DNA and RNA molecules with single molecule sensitivity. The method of the present invention comprises (1) the electrically controlled unzipping of DNA (or RNA) double strands, and (2) the readout of the molecule's identity (or code) using one or more molecule signal detection.

公开(公告)号：EP0758681A3

公开(公告)日：1997-06-04

申请号：EP96201406.4

申请日：1990-02-14

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  THE GENERAL HOSPITAL CORPORATION ,  HARVARD UNIVERSITY ,  AMIRA INC.

发明人： Kaddurah-Daouk, Rima ,  Daouk, Ghaleb ,  Kingston, Robert ,  Green, Michael ,  Schimmel, Paul ,  Lillie, James W. ,  Putney, Scott D.

IPC分类号： C12N15/00

CPC分类号： C12N15/1137 ,  A61K31/00 ,  A61K31/195 ,  A61K31/415 ,  A61K31/505 ,  A61K31/66 ,  A61K38/00 ,  A61K48/00 ,  C07K14/82 ,  C12N9/12 ,  C12N9/1223 ,  C12Q1/50 ,  C12Y207/0102 ,  C12Y207/03002 ,  C12Y207/04003 ,  C12Y406/01001 ,  G01N33/573 ,  G01N33/57484 ,  G01N2333/01

摘要： A method of inhibiting growth rate, transformation or metastasis of mammalian cells, particularly epithelial cells, in which activity of at least one enzyme which participates in purine metabolism and regulations of nucleotide levels is elevated. In particular, a method of inhibiting transformation of mammalian cells by a DNA tumor virus, a DNA tumor virus factor or other factor which has an equivalent effect on cells.

摘要翻译： 一种抑制哺乳动物细胞，特别是上皮细胞的生长速度，转化或转移的方法，其中至少一种参与嘌呤代谢的酶的活性和核苷酸水平的调节被提高。 具体而言，涉及通过DNA肿瘤病毒，DNA肿瘤病毒因子或对细胞具有等效作用的其他因子来抑制哺乳动物细胞转化的方法。

公开(公告)号：EP0758681A2

公开(公告)日：1997-02-19

申请号：EP96201406.4

申请日：1990-02-14

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  THE GENERAL HOSPITAL CORPORATION ,  HARVARD UNIVERSITY ,  AMIRA INC.

发明人： Kaddurah-Daouk, Rima ,  Daouk, Ghaleb ,  Kingston, Robert ,  Green, Michael ,  Schimmel, Paul ,  Lillie, James W. ,  Putney, Scott D.

IPC分类号： C12N15/00

CPC分类号： C12N15/1137 ,  A61K31/00 ,  A61K31/195 ,  A61K31/415 ,  A61K31/505 ,  A61K31/66 ,  A61K38/00 ,  A61K48/00 ,  C07K14/82 ,  C12N9/12 ,  C12N9/1223 ,  C12Q1/50 ,  C12Y207/0102 ,  C12Y207/03002 ,  C12Y207/04003 ,  C12Y406/01001 ,  G01N33/573 ,  G01N33/57484 ,  G01N2333/01

摘要： A method of inhibiting growth rate, transformation or metastasis of mammalian cells, particularly epithelial cells, in which activity of at least one enzyme which participates in purine metabolism and regulations of nucleotide levels is elevated. In particular, a method of inhibiting transformation of mammalian cells by a DNA tumor virus, a DNA tumor virus factor or other factor which has an equivalent effect on cells.

公开(公告)号：EP0458901B1

公开(公告)日：1997-12-17

申请号：EP90904105.5

申请日：1990-02-14

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  HARVARD UNIVERSITY ,  THE GENERAL HOSPITAL CORPORATION ,  AMIRA, INC.

发明人： KADDURAH-DAOUK, Rima ,  DAOUK, Ghaleb ,  SCHIMMEL, Paul, R. ,  KINGSTON, Robert ,  LILLIE, James, W. ,  GREEN, Michael ,  PUTNEY, Scott, D.

IPC分类号： A61K38/55 ,  C12Q1/50

CPC分类号： C12N15/1137 ,  A61K31/00 ,  A61K31/195 ,  A61K31/415 ,  A61K31/505 ,  A61K31/66 ,  A61K38/00 ,  A61K48/00 ,  C07K14/82 ,  C12N9/12 ,  C12N9/1223 ,  C12Q1/50 ,  C12Y207/0102 ,  C12Y207/03002 ,  C12Y207/04003 ,  C12Y406/01001 ,  G01N33/573 ,  G01N33/57484 ,  G01N2333/01

摘要： A method of inhibiting growth rate, transformation or metastasis of mammalian cells, particularly epithelial cells, in which activity of at least one enzyme which participates in purine metabolism and regulation of nucleotide levels is elevated. In particular, a method of inhibiting transformation of mammalian cells by a DNA tumor virus, a DNA tumor virus factor or other factor which has an equivalent effect on cells.

公开(公告)号：EP0699758A1

公开(公告)日：1996-03-06

申请号：EP95100871.3

申请日：1989-12-12

申请人： HARVARD UNIVERSITY ,  COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

发明人： Hoover, Edward A. ,  Mullins, James I.

IPC分类号： C12N15/48 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/525 ,  C12N7/00 ,  C12N2740/13021 ,  C12N2740/13022 ,  C12N2740/13061 ,  Y10S424/819

摘要： Molecular clones of feline leukemia virus isolates that encode (a) a prototype highly infectious, minimally pathogenic virus, (b) a variant genome that is replication-defective and associated with a fatal immunodeficiency in cats similar to AIDS (FAIDS) or (c) a chimeric genome that is replication-competent and induces FAIDS. These molecular clones may be used to generate cell lines producing infectious virus which is useful in the preparation of vaccines or in the generation of viremia or disease challenge systems.

摘要翻译： 猫科白血病病毒分离株的分子克隆编码（a）原型感染性极低的致病病毒，（b）与艾滋病相似的猫（FAIDS）中复制缺陷并与致命免疫缺陷相关的变异基因组，或（c） 具有复制能力并诱导FAIDS的嵌合基因组。 这些分子克隆可用于产生产生感染性病毒的细胞系，其可用于制备疫苗或产生病毒血症或疾病挑战系统。

公开(公告)号：EP1140737A2

公开(公告)日：2001-10-10

申请号：EP99967640.6

申请日：1999-12-22

申请人： HARVARD UNIVERSITY

发明人： DEWITTE, Robert, S. ,  SHAKHNOVICH, Eugene, I.

IPC分类号： C07B61/00 ,  C07H19/01 ,  G06F17/50

CPC分类号： G06F19/706 ,  G06F19/16 ,  G06F19/18

摘要： A system and method for providing improved de novo structure-based drug design that includes a method for more accurately predicting binding free energy. The system and method use a coarse-graing model with corresponding knowledge-based potential data to grow ligand candidates and libraries of ligand candidates. In light of the present inventions using coarse-graining model, the novel growth method of the present invention uses a Metropolis Monte Carlo selection process which result in a low energy structure that is not necessarily the lowest energy structure, yet results in a better ligand candidate.

公开(公告)号：EP0458901A1

公开(公告)日：1991-12-04

申请号：EP90904105.0

申请日：1990-02-14

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  HARVARD UNIVERSITY ,  THE GENERAL HOSPITAL CORPORATION

发明人： KADDURAH-DAOUK, Rima ,  DAOUK, Ghaleb ,  SCHIMMEL, Paul, R. ,  KINGSTON, Robert ,  LILLIE, James, W. ,  GREEN, Michael ,  PUTNEY, Scott, D.

IPC分类号： A61K38 ,  A61K31 ,  A61K45 ,  A61K48 ,  A61P31 ,  A61P35 ,  C07D233 ,  C07D303 ,  C07H19 ,  C07K14 ,  C12N9 ,  C12N15 ,  C12Q1 ,  G01N33

CPC分类号： C12N15/1137 ,  A61K31/00 ,  A61K31/195 ,  A61K31/415 ,  A61K31/505 ,  A61K31/66 ,  A61K38/00 ,  A61K48/00 ,  C07K14/82 ,  C12N9/12 ,  C12N9/1223 ,  C12Q1/50 ,  C12Y207/0102 ,  C12Y207/03002 ,  C12Y207/04003 ,  C12Y406/01001 ,  G01N33/573 ,  G01N33/57484 ,  G01N2333/01

摘要： Procédé permettant d'inhiber le taux de croissance, la transformation ou métastase de cellules de mammifères, notamment de cellules épithéliales, où l'activité d'un enzyme au moins, participant dans les taux de métabolisme de la purine et de régulation des nucléotides, est élevée. On décrit en particulier un procédé permettant d'inhiber la transformation de cellules de mammifère par un virus oncogène de l'ADN, un facteur de virus oncogène de l'ADN, ou par d'autres facteurs ayant un effet semblable sur les cellules.