公开(公告)号：EP2413985B8

公开(公告)日：2015-02-25

申请号：EP10717224.9

申请日：2010-03-31

申请人： Enbio Limited

发明人： O'NEILL, Liam ,  O'SULLIVAN, Caroline

IPC分类号： A61L27/54 ,  A61L27/56 ,  A61L27/04 ,  A61L27/34

CPC分类号： A61L27/56 ,  A61L27/04 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/606

公开(公告)号：EP2413985A2

公开(公告)日：2012-02-08

申请号：EP10717224.9

申请日：2010-03-31

申请人： Enbio Limited

发明人： O'NEILL, Liam ,  O'SULLIVAN, Caroline

IPC分类号： A61L27/54 ,  A61L27/56

CPC分类号： A61L27/56 ,  A61L27/04 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/606

摘要： Disclosed herein are methods of treating an article surface. The method comprises delivering a polymer and drug to a medical implant having a porous surface and using at least one particle stream from at least one fluid jet to subsequently remove the polymer from the outer surface of the metal substrate, thereby retaining the therapeutic agent and polymer within the pores of the implant.

公开(公告)号：EP2061629B1

公开(公告)日：2011-05-18

申请号：EP07842279.7

申请日：2007-09-11

申请人： Enbio Limited

发明人： O'DONOGHUE, John, Gerard ,  HAVERTY, Donncha

IPC分类号： B24C11/00 ,  A61F2/30 ,  A61L27/54

CPC分类号： C23C16/0227 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2002/30092 ,  A61F2002/30906 ,  A61F2002/30924 ,  A61F2210/0014 ,  A61F2310/00011 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00047 ,  A61F2310/00059 ,  A61F2310/00071 ,  A61F2310/00095 ,  A61F2310/00131 ,  A61F2310/0097 ,  A61F2310/00976 ,  A61L27/04 ,  A61L27/06 ,  A61L27/50 ,  A61L27/54 ,  A61L29/02 ,  A61L29/14 ,  A61L29/16 ,  A61L31/022 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/622 ,  B05D1/12 ,  B05D3/12 ,  B05D5/06 ,  B05D7/14 ,  B24C11/00 ,  B24C11/005

摘要： Disclosed herein are methods of treating an article surface. The method comprises removing a metal oxide surface from the metal substrate to expose a metal surface; and delivering particles comprising a dopant from at least one fluid jet to the metal surface to impregnate the surface of the article with the dopant. The method also comprises delivering substantially simultaneously a first set of particles comprising a dopant and a second set of particles comprising an abrasive from at least one fluid jet to a surface of an article to impregnate the surface of the article with the dopant.

公开(公告)号：EP2061629A2

公开(公告)日：2009-05-27

申请号：EP07842279.7

申请日：2007-09-11

申请人： Enbio Limited

发明人： O'DONOGHUE, John, Gerard ,  HAVERTY, Donncha

IPC分类号： B24C11/00 ,  A61F2/30 ,  A61L27/54

CPC分类号： C23C16/0227 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2002/30092 ,  A61F2002/30906 ,  A61F2002/30924 ,  A61F2210/0014 ,  A61F2310/00011 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00047 ,  A61F2310/00059 ,  A61F2310/00071 ,  A61F2310/00095 ,  A61F2310/00131 ,  A61F2310/0097 ,  A61F2310/00976 ,  A61L27/04 ,  A61L27/06 ,  A61L27/50 ,  A61L27/54 ,  A61L29/02 ,  A61L29/14 ,  A61L29/16 ,  A61L31/022 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/622 ,  B05D1/12 ,  B05D3/12 ,  B05D5/06 ,  B05D7/14 ,  B24C11/00 ,  B24C11/005

摘要： Disclosed herein are methods of treating an article surface. The method comprises removing a metal oxide surface from the metal substrate to expose a metal surface; and delivering particles comprising a dopant from at least one fluid jet to the metal surface to impregnate the surface of the article with the dopant. The method also comprises delivering substantially simultaneously a first set of particles comprising a dopant and a second set of particles comprising an abrasive from at least one fluid jet to a surface of an article to impregnate the surface of the article with the dopant.

公开(公告)号：EP3978191A1

公开(公告)日：2022-04-06

申请号：EP21208806.6

申请日：2016-09-28

申请人： Enbio Limited

发明人： TWOMEY, Barry ,  O'DONOGHUE, John ,  ROCHE, Kevin ,  O'NEILL, Liam ,  FIORINI, Paolo Vincenzo Ercole

IPC分类号： B24C11/00 ,  C23C24/04 ,  B24C1/00

摘要： A metal surface treatment method wherein the surface (10) is simultaneously bombarded with a mixture of abrasive particles (4) and dopant particles (6) which are delivered at a velocity in the range of 50-250 m/sec, and thereby depositing the dopant material on the surface, the dopant being a polymer and the abrasive having an average particle size in the range of 5-5000 microns. Also provided is an article (8) having a surface treated by such a method.

公开(公告)号：EP3356082A1

公开(公告)日：2018-08-08

申请号：EP16777957.8

申请日：2016-09-28

申请人： Enbio Limited

发明人： TWOMEY, Barry ,  O'DONOGHUE, John ,  ROCHE, Kevin ,  O'NEILL, Liam ,  FIORINI, Paolo Vincenzo Ercole

IPC分类号： B24C11/00 ,  C23C24/04 ,  B24C1/00

CPC分类号： C23C24/04 ,  B24C1/00 ,  B24C11/005

摘要： A metal surface treatment method wherein the surface (10) is simultaneously bombarded with a mixture of abrasive particles (4) and dopant particles (6) which are delivered at a velocity in the range of 50-250 m/sec, and thereby depositing the dopant material on the surface. Also provided is an article (8) having a surface treated by such a method.

公开(公告)号：EP2413985B1

公开(公告)日：2015-01-14

申请号：EP10717224.9

申请日：2010-03-31

申请人： Enbio Limited

发明人： O'NEILL, Liam ,  O'SULLIVAN, Caroline

IPC分类号： A61L27/54 ,  A61L27/56 ,  A61L27/04 ,  A61L27/34

CPC分类号： A61L27/56 ,  A61L27/04 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/606

公开(公告)号：EP2262452A1

公开(公告)日：2010-12-22

申请号：EP09720394.7

申请日：2009-03-13

申请人： Enbio Limited

发明人： O'DONOGHUE, John, Gerard ,  O'HARE, Peter

IPC分类号： A61F2/90 ,  B24C1/06 ,  A61L31/02 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L31/18

CPC分类号： A61L31/022 ,  A61F2/91 ,  A61F2250/0067 ,  A61F2310/0097 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/00 ,  B24C1/06 ,  B24C11/00

摘要： Disclosed herein are methods of modifying a nitinol surface by using abrasive blasting techniques. The surface modification can be performed by abrasively blasting the surface and delivering at least one dopant from one or more fluid jets to cause the at least one dopant to impregnate and/or coat the nitinol surface. The nitinol surface can form a portion or all of a medical device, such as an implantable medical device, e.g., a stent.

公开(公告)号：EP3119923A1

公开(公告)日：2017-01-25

申请号：EP15711191.5

申请日：2015-03-20

申请人： Enbio Limited

发明人： TWOMEY, Barry ,  STANTON, Kenneth ,  O'DONOGHUE, John ,  ROCHE, Kevin ,  MOHAN, Joseph

IPC分类号： C23C24/04 ,  B24C1/00 ,  B24C3/02 ,  B24C11/00

CPC分类号： B24C11/005 ,  B24C1/00 ,  B24C11/00 ,  C23C4/134 ,  C23C4/18 ,  C23C24/04

摘要： A method of treating a substrate, the method comprising: delivering substantially simultaneously a first set of particles comprising a dopant and a second set of particles comprising an abrasive from at least one fluid jet to a surface of the substrate, to impregnate the surface of the substrate with the dopant; wherein the dopant comprises a corrosion-inhibiting or adhesion-promoting species, such as to form a corrosion-inhibiting or adhesion-promoting coating at or on the surface of the substrate. Also provided is an article comprising a substrate having a corrosion-inhibiting or adhesion-promoting coating, the said coating comprising particles of a corrosion-inhibiting or adhesion-promoting species that impregnate the surface of the substrate (e.g. as produced by the above method).

摘要翻译： 一种处理基材的方法，所述方法包括：基本上同时地将包含掺杂剂的第一组颗粒和包含研磨剂的第二组颗粒从至少一种流体射流输送到所述基底的表面，以浸渍所述基底的表面 衬底与掺杂剂; 其中所述掺杂剂包含腐蚀抑制或粘附促进物质，例如在所述基材表面上或表面上形成腐蚀抑制或粘附促进涂层。 还提供了包含具有腐蚀抑制或粘附促进涂层的基材的制品，所述涂层包含浸渍基材表面的腐蚀抑制或粘附促进物质的颗粒（例如通过上述方法制备） 。

公开(公告)号：EP2651464A2

公开(公告)日：2013-10-23

申请号：EP11817414.3

申请日：2011-12-09

申请人： Enbio Limited

发明人： O'NEILL, Liam ,  O'DONOGHUE, John

IPC分类号： A61L27/34 ,  A61L27/38 ,  A61L27/50 ,  A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14

CPC分类号： A61L31/14 ,  A61L27/34 ,  A61L27/38 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L2400/18 ,  A61L2420/02

摘要： The present invention is directed to methods for producing a coated substrate, including dissolving at least one biomolecule to form a solution; nebulizing the solution to form a liquid aerosol; combining the liquid aerosol and a plasma to form a coating; and depositing, in the absence of reactive monomers, the coating onto a substrate surface. In an aspect, the substrate can be an implantable medical device.