公开(公告)号：EP3049444A4

公开(公告)日：2017-06-07

申请号：EP14847881

申请日：2014-09-26

申请人： FIVE3 GENOMICS LLC ,  NANT HOLDINGS IP LLC

发明人： SANBORN JOHN ZACHARY ,  VASKE CHARLES JOSEPH ,  BENZ STEPHEN CHARLES ,  RABIZADEH SHAHROOZ ,  HENSLEY NICOLE ,  SOON-SHIONG PATRICK

IPC分类号： G06F19/10 ,  C07K19/00 ,  C12N15/33 ,  C12Q1/68

CPC分类号： G06F19/22

公开(公告)号：EP3149641A4

公开(公告)日：2018-01-24

申请号：EP15799022

申请日：2015-06-01

申请人： NANTOMICS LLC ,  NANT HOLDINGS IP LLC

发明人： RABIZADEH SHAHROOZ ,  SOON-SHIONG PATRICK ,  SANBORN JOHN ZACHARY ,  VASKE CHARLES JOSEPH ,  BENZ STEPHEN CHARLES

IPC分类号： G06F19/18 ,  G06F19/10

CPC分类号： G06F19/18 ,  G06F19/22

摘要： Omics patient data are analyzed using sequences or diff objects of tumor and matched normal tissue to identify patient and disease specific mutations, using transcriptomic data to identify expression levels of the mutated genes, and pathway analysis based on the so obtained omic data to identify specific pathway characteristics for the diseased tissue. Most notably, many different tumors have shared pathway characteristics, and identification of a pathway characteristic of a tumor may thus indicate effective treatment options ordinarily not considered when tumor analysis is based on anatomical tumor type only.

公开(公告)号：EP3286361A1

公开(公告)日：2018-02-28

申请号：EP16784102

申请日：2016-04-25

申请人： NANTOMICS LLC ,  NANT HOLDINGS IP LLC

发明人： NGUYEN ANDREW ,  NIAZI KAYVAN ,  SOON-SHIONG PATRICK ,  RABIZADEH SHAHROOZ ,  BENZ STEPHEN CHARLES

IPC分类号： C40B30/02 ,  A61K35/17 ,  A61K49/00 ,  A61P35/00 ,  C07K16/00

CPC分类号： A61K35/17 ,  C07K16/005 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/32 ,  G06F19/18 ,  G06F19/22

摘要： Contemplated compositions and methods are directed to cancer neoepitopes and uses of such neoepitopes, especially to generate synthetic antibodies against neoepitopes that may then be employed in the manufacture of a therapeutic agent. Preferred therapeutic agents will comprise a synthetic antibody against a neoepitope, and most preferably in combination with a cellular or non-cellular component for use as a diagnostic or therapeutic agent.

公开(公告)号：EP2764460A4

公开(公告)日：2015-08-05

申请号：EP12838194

申请日：2012-10-06

申请人： NANT HOLDINGS IP LLC

发明人： SOON-SHIONG PATRICK ,  SANBORN JOHN ZACHARY ,  BENZ STEPHEN CHARLES ,  VASKE CHARLES JOSEPH

IPC分类号： G06F19/00 ,  G06Q50/22

CPC分类号： G06F19/322 ,  G06F19/3418 ,  G06Q50/22 ,  G16H10/60

摘要： Healthcare object (HCO) discriminator systems and methods are presented. Systems can obtain a digital representation of a scene via a sensor interface. An HCO discriminator platform analyzes the digital representation to discriminate objects within the scene as being associated with a type of HCO or as being unrelated to a type of HCO. Once the HCO recognition platform determines that a type of HCO is relevant, it instantiates an actual HCO. The HCO can be routed to one or more destinations based on routing rules generated from a template or based on the manner in which the objects in the scene were discriminated.

公开(公告)号：EP2907039A4

公开(公告)日：2016-06-15

申请号：EP13846109

申请日：2013-10-09

申请人： FIVE3 GENOMICS LLC

发明人： VASKE CHARLES JOSEPH ,  SEDGEWICK ANDREW J ,  BENZ STEPHEN CHARLES

IPC分类号： G06F19/12 ,  G06F19/24

CPC分类号： G06F19/12 ,  G06F19/24 ,  G06F19/3437 ,  G16H50/50

摘要： Contemplated systems and methods provide for machine learning and identification of regulatory interactions in biological pathways using a probabilistic graphical model, and especially for identification of interaction correlations among the regulatory parameters.

摘要翻译： 考虑的系统和方法提供一种用于机器学习和使用概率图形模型在生物途径调控性相互作用的鉴定，特别是对于爱的调节参数之间的相关性相互作用的鉴定。

公开(公告)号：EP3069285A4

公开(公告)日：2017-08-30

申请号：EP14862192

申请日：2014-11-13

申请人： FIVE3 GENOMICS LLC

发明人： BENZ STEPHEN CHARLES ,  SANBORN JOHN ZACHARY ,  VASKE CHARLES JOSEPH

IPC分类号： G06F19/10 ,  G06F17/30 ,  G06F19/22 ,  G06F19/28 ,  H04L29/08

CPC分类号： H04L67/06 ,  G06F17/30076 ,  G06F19/22 ,  G06F19/28

公开(公告)号：EP2788770A4

公开(公告)日：2015-06-10

申请号：EP12854939

申请日：2012-12-07

申请人： FIVE3 GENOMICS LLC

发明人： SANBORN JOHN ZACHARY ,  VASKE CHARLES JOSEPH ,  BENZ STEPHEN CHARLES

IPC分类号： G01N33/574 ,  C12Q1/68 ,  G06F19/22 ,  G06F19/24

CPC分类号： C12Q1/6886 ,  C12Q1/6869 ,  C12Q2600/106 ,  C12Q2600/172 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24 ,  G16H50/20

摘要： Contemplated systems and methods allow for computational genomic analysis using paired-end sequence analysis and split read refinement to thereby identify high-confidence breakpoints associated with high copy numbers and orientation of rearrangements, which is then the basis for full reconstruction of double minutes (DM). In especially preferred aspects, the DM will also include an oncogene or tumor suppressor gene, and/or may be found in blood or blood derived fluids.

公开(公告)号：EP3005199A4

公开(公告)日：2017-05-10

申请号：EP14804788

申请日：2014-05-28

申请人： FIVE3 GENOMICS LLC

发明人： BENZ STEPHEN CHARLES ,  SZETO CHRISTOPHER

IPC分类号： G06F19/12

CPC分类号： G06F19/10 ,  G06F19/12 ,  G06F19/345 ,  G16H50/20

摘要： Systems and methods are presented in which omics data from multiple cell or tissue samples are used to identify pathway elements that are associated with a treatment parameter of the cell or tissue (e.g., resistance towards a specific drug). So identified pathway elements are then modulated in silico in a statistical factor graph model to provide a modified data set that is re-evaluated with respect to the treatment parameter. Such systems and models are particularly useful for recommendation of multi-drug treatments for treatment-nave patients.

摘要翻译： 呈现了系统和方法，其中使用来自多个细胞或组织样品的组学数据来识别与细胞或组织的治疗参数（例如对特定药物的抗性）相关的通路元件。 如此识别的通路元件然后在统计因子图模型中以计算机模块（in silico）被调制，以提供经修改的数据集，其相对于治疗参数被重新评估。 这样的系统和模型对推荐治疗中心患者的多药物治疗特别有用。