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公开(公告)号：EP2820008B1
公开(公告)日：2016-12-14
申请号：EP13755811.0
申请日：2013-03-01
申请人： Genentech, Inc. , Forma TM, LLC.
发明人： BAIR, Kenneth, W. , BAUMEISTER, Timm, R. , DRAGOVICH, Peter , LIU, Xiongcai , PATEL, Snahel , ZAK, Mark , ZHAO, Guiling , ZHANG, Yamin , ZHENG, Xiaozhang
IPC分类号： C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D519/00 , A61K31/438 , A61K31/444 , A61K31/4545 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： C07D519/00 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
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公开(公告)号：EP2820018A1
公开(公告)日：2015-01-07
申请号：EP13754380.7
申请日：2013-03-01
申请人： Genentech, Inc. , Forma TM, LLC.
发明人： BAIR, Kenneth W. , BAUMEISTER, Timm R. , BUCKMELTER, Alexandre J. , CLODFELTER, Karl H. , DRAGOVICH, Peter , GUNZNER-TOSTE, Janet , HAN, Bingsong , LIN, Jian , LIU, Xiongcai , REYNOLDS, Dominic J. , SMITH, Chase C. , WANG, Zhongguo , ZAK, Mark , ZHANG, Yamin , ZHAO, Guiling , ZHENG, Xiaozhang , YUEN, Po-Wai
IPC分类号： C07D471/04 , C07D491/04 , C07D495/04 , A61K31/437 , A61P35/00
CPC分类号： C07D519/00 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/496 , A61K31/5025 , A61K31/5377 , A61K31/5386 , A61K31/551 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
摘要翻译： 本发明涉及某些酰氨基 - 苄基亚砜和砜化合物，包含这些化合物的药物组合物，以及使用这些化合物的治疗方法。
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公开(公告)号：EP2820008A1
公开(公告)日：2015-01-07
申请号：EP13755811.0
申请日：2013-03-01
申请人： Genentech, Inc. , Forma TM, LLC.
发明人： BAIR, Kenneth, W. , BAUMEISTER, Timm, R. , DRAGOVICH, Peter , LIU, Xiongcai , PATEL, Snahel , ZAK, Mark , ZHAO, Guiling , ZHANG, Yamin , ZHENG, Xiaozhang
IPC分类号： C07D401/12 , C07D401/14 , A61K31/438 , A61K31/444 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： C07D519/00 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
摘要： Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号：EP2493865A2
公开(公告)日：2012-09-05
申请号：EP10805862.9
申请日：2010-08-27
发明人： ALIAGAS, Ignacio , GRADL, Stefan , GUNZNER, Janet , LEE, Wendy , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , ZHAO, Guiling , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen , MORENO, David , REN, Li , WENGLOWSKY, Steven Mark
IPC分类号： C07D239/94 , C07D403/12 , C07D405/12 , C07D471/04 , A61K31/517 , A61K31/519 , A61P35/00
CPC分类号： C07D239/94 , C07D403/12 , C07D405/12 , C07D471/04
摘要： Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof,
for in vitro, in situ , and
in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.摘要翻译： 式I化合物可用于抑制Raf激酶。 公开了使用式I化合物及其立体异构体，互变异构体，前药和药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞中的这些病症或相关病理学病症的方法。
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公开(公告)号：EP3082872B1
公开(公告)日：2020-12-09
申请号：EP14821453.9
申请日：2014-12-16
申请人： Genentech, Inc. , Medimmune Limited
发明人： FLYGARE, John , GUNZNER-TOSTE, Janet , PILLOW, Thomas , SAFINA, Brian , VERMA, Vishal , WEI, Binqing , ZHAO, Guiling , STABEN, Leanna , HOWARD, Philip, Wilson , MASTERSON, Luke
IPC分类号： A61K47/68 , A61K31/5517 , A61P35/00 , A61P35/02
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公开(公告)号：EP3082875B1
公开(公告)日：2020-11-25
申请号：EP14824688.7
申请日：2014-12-16
申请人： Genentech, Inc.
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公开(公告)号：EP3075730B1
公开(公告)日：2018-10-24
申请号：EP16155153.6
申请日：2011-06-01
申请人： Genentech, Inc.
发明人： BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHAN, Bryan K. , CHEN, Huifen , ESTRADA, Anthony , GUNZNER, Janet L. , SHORE, Daniel , SWEENEY, Zachary Kevin , WANG, Shumei , ZHAO, Guiling
IPC分类号： C07D403/14 , C07D473/16 , A61K31/52 , A61P25/16
CPC分类号： C07D413/14 , C07D403/14 , C07D413/12 , C07D473/16 , C07D498/06 , C07D498/08
摘要： Compounds of the formula I or pharmaceutically acceptable salts thereof, wherein m, n. X, R 1 , R 2 , R 3 , R 5 , R 6 and R 7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
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8.发明授权2-PHENYLAMINOPYRIMIDINE DERIVATIVES AS KINASE LRRK2 MODULATORS FOR THE TREATMENT OF PARKINSON'S DISEASE 有权作为激酶LRRK2调节剂的2-苯基氨基嘧啶衍生物治疗帕金森氏病
公开(公告)号：EP2785699B1
公开(公告)日：2017-09-06
申请号：EP12791761.5
申请日：2012-11-28
申请人： Genentech, Inc.
发明人： BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHAN, Bryan K. , CHEN, Huifen , ESTRADA, Anthony , GUNZNER-TOSTE, Janet , SHORE, Daniel , SWEENEY, Zachary , WANG, Shumei , ZHAO, Guiling
IPC分类号： C07D239/47 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D487/04 , C07D498/08 , C07D491/107 , A61K31/505 , A61K31/506 , A61P25/16
CPC分类号： C07D498/18 , C07D239/47 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D487/04 , C07D491/107 , C07D498/08 , C07D498/10
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公开(公告)号：EP3082875A2
公开(公告)日：2016-10-26
申请号：EP14824688.7
申请日：2014-12-16
发明人： LEE, Ho Huat , TERCEL, Moana , FLYGARE, John A. , GUNZNER-TOSTE, Janet , PILLOW, Thomas H. , SAFINA, Brian , STABEN, Leanna , VERMA, Vishal , WEI, BinQing , ZHAO, Guiling
CPC分类号： A61K47/48715 , A61K47/6803 , A61K47/6851 , A61K47/6889 , A61K2039/505 , C07K16/28 , C07K16/2851 , C07K16/2863 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76
摘要： This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
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公开(公告)号：EP3082874A2
公开(公告)日：2016-10-26
申请号：EP14824686.1
申请日：2014-12-16
申请人： Genentech, Inc.
发明人： FLYGARE, John , GUNZNER-TOSTE, Janet , PILLOW, Thomas , SAFINA, Brian , VERMA, Vishal , WEI, Binqing , ZHAO, Guiling , STABEN, Leanna
CPC分类号： A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6889 , C07K16/28 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76
摘要： This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
摘要翻译： 本发明涉及拟肽连接体和其抗体药物偶联物，含有它们的药物组合物，以及它们在治疗癌症的预防或治疗中的用途。
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