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公开(公告)号：EP2928469A4
公开(公告)日：2016-11-02
申请号：EP13860778
申请日：2013-12-06
IPC分类号： C07D277/00 , A61K31/426 , A61P39/04 , C07D277/12
CPC分类号： C07D277/12 , C07B2200/13
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2.发明公开NOVEL SALTS AND POLYMORPHS OF DESAZADESFERRITHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS 审中-公开十二烷基硫杂环己烯类聚醚类似物金属螯合剂的新型盐和多元酸
公开(公告)号：EP2303853A2
公开(公告)日：2011-04-06
申请号：EP09798650.9
申请日：2009-07-14
IPC分类号： C07D277/22 , C07D277/20 , A61K31/426 , A61P9/10 , A61P25/08 , A61P9/02
CPC分类号： C07D277/12 , C07D277/10
摘要： Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.
摘要翻译： 本文公开了desazadesferrithiocin聚醚（DADFT-PE）类似物的新盐和多晶型物，以及包含它们的药物组合物以及它们作为用于治疗疾病的金属螯合剂的应用。 还提供了人或动物受试者中铁和其他金属螯合的方法用于治疗金属超载和毒性。
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公开(公告)号：EP2928469A1
公开(公告)日：2015-10-14
申请号：EP13860778.3
申请日：2013-12-06
IPC分类号： A61K31/426 , C07D277/00 , C07D277/12 , A61P39/04
CPC分类号： C07D277/12 , C07B2200/13
摘要： The present invention provides a solid form and compositions thereof, which are useful as metal chelators and which exhibit desirable characteristics for the same.
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公开(公告)号：EP2787994A1
公开(公告)日：2014-10-15
申请号：EP12856135.4
申请日：2012-12-07
IPC分类号： A61K31/426 , C07D277/00
CPC分类号： C07D277/12 , A61K9/4866 , A61K31/426
摘要： The present invention provides, among other things, effective oral formulations based on desazadesferrithiocin polyether (DADFT-PE) analogues, salts and polymorphs thereof, as well as their application for treatment of metal overload, in particular, iron overload, and associated diseases, disorders and conditions.
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公开(公告)号：EP2970162A1
公开(公告)日：2016-01-20
申请号：EP14718493.1
申请日：2014-03-13
发明人： TENJARLA, Srini , MCGEE, Paul
IPC分类号： C07D277/12 , A61K31/426 , A61P43/00
CPC分类号： C07D277/12 , C07B2200/13
摘要： The present invention provides a solid form and compositions thereof, which are useful as metal chelators and which exhibit desirable characteristics for the same.
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公开(公告)号：EP2787994A4
公开(公告)日：2015-08-26
申请号：EP12856135
申请日：2012-12-07
发明人： RIENHOFF HUGH Y JR
IPC分类号： A61K31/426 , A61K9/48 , A61P39/04
CPC分类号： C07D277/12 , A61K9/4866 , A61K31/426
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7.发明公开PRODRUGS OF DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS 审中-公开从金属氯化物中脱除金属酞菁聚醚类似物的脱除
公开(公告)号：EP2459544A4
公开(公告)日：2012-12-05
申请号：EP10806863
申请日：2010-07-26
发明人： MCCALL JOHN M , RIENHOFF HUGH Y
IPC分类号： C07D277/08 , A61K31/426 , A61K31/427 , A61P3/10 , C07D417/10 , C07D417/12
CPC分类号： C07D277/12 , A61K31/426 , A61K31/427
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8.发明公开PRODRUGS OF DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS 审中-公开作为金属螯合剂的十七烷基癸二酸聚醚类似物的前体
公开(公告)号：EP2459544A2
公开(公告)日：2012-06-06
申请号：EP10806863.6
申请日：2010-07-26
IPC分类号： C07D277/08 , C07D417/12 , C07D417/10 , A61K31/426 , A61K31/427 , A61P3/10
CPC分类号： C07D277/12 , A61K31/426 , A61K31/427
摘要： Disclosed herein are new compounds of desazadesferrothiocin polyether (DADFT- PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.
摘要翻译： 本发明公开了脱氮脱铁螺菌素聚醚（DADFT-PE）类似物的新化合物，以及包含它们的药物组合物及其作为用于治疗疾病的金属螯合剂的应用。 还提供了人或动物受试者中铁和其他金属螯合的方法用于治疗金属超载和毒性。
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9.发明公开NOVEL SALTS AND POLYMORPHS OF DESAZADESFERRITHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS 审中-公开新型多金属氧酸盐及其多金属盐化合物金属化学
公开(公告)号：EP2303853A4
公开(公告)日：2011-08-10
申请号：EP09798650
申请日：2009-07-14
发明人： TAPPER AMY E , RIENHOFF HUGH Y , PARENT STEPHAN D , ANDRES PATRICIA , HANKO JASON A , ZHANG HUAMIN
IPC分类号： C07D277/22 , A61K31/426 , A61P9/02 , A61P9/10 , A61P25/08 , C07D277/20
CPC分类号： C07D277/12 , C07D277/10
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