公开(公告)号：EP2766038B1

公开(公告)日：2016-03-02

申请号：EP13785956.7

申请日：2013-09-03

申请人： Firat Üniversitesi

发明人： ÖZDARENDELI, Aykut ,  ÇANAKOGLU, Nurettin ,  BERBER, Engin ,  AKTAS, Münir ,  KALKAN, Ahmet

IPC分类号： A61K39/12

CPC分类号： A61K39/12 ,  A61K2039/5252 ,  A61K2039/55505 ,  C12N2760/12034

公开(公告)号：EP2766038A1

公开(公告)日：2014-08-20

申请号：EP13785956.7

申请日：2013-09-03

申请人： Firat Üniversitesi

发明人： ÖZDARENDELI, Aykut ,  ÇANAKOGLU, Nurettin ,  BERBER, Engin ,  AKTAS, Münir ,  KALKAN, Ahmet

IPC分类号： A61K39/12

CPC分类号： A61K39/12 ,  A61K2039/5252 ,  A61K2039/55505 ,  C12N2760/12034

摘要： Viral antigens are obtained by producing the Kelkit06 strain of the CCHF virus isolated in our country in the Vero E6 cells. Concentration, purification and inactivation of the CCHF antigens are realized. Then, it is adjuvanted with ALUM (aluminum hydroxide) adjuvant and cell culture based inactivated CCHF vaccine is developed by the addition of 0.001% of thimerosal into the final vaccine formulation. The vaccine tested in the IFNAR mice demonstrates formation of high neutralizing antibody titer and protection.