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公开(公告)号：EP3924374A1
公开(公告)日：2021-12-22
申请号：EP20706418.9
申请日：2020-02-13
申请人： Fundación Instituto de Investigación contra la Leucemia Josep Carreras (IJC) , Institució Catalana De Recerca I Estudis Avançats (ICREA) , Fundació Institut d'Investigació en Ciéncies de la Salut Germans Tiras i Pujol (IGTP)
发明人： MENÉNDEZ BUJÁN, Pablo , SANCHEZ MARTÍNEZ, Diego , BUENO UROZ, Clara , GUTIÉRREZ AGÜERA, Francisco , ROCA-HO, Heleia
IPC分类号： C07K14/725 , C07K16/28 , C12N5/0783 , A61P35/00 , A61K39/00
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公开(公告)号：EP3867363A1
公开(公告)日：2021-08-25
申请号：EP19786816.9
申请日：2019-10-18
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公开(公告)号：EP3696191A1
公开(公告)日：2020-08-19
申请号：EP19382104.8
申请日：2019-02-14
申请人： Fundación Instituto de Investigación contra la Leucemia Josep Carreras (IJC) , Institució Catalana De Recerca I Estudis Avançats (ICREA)
发明人： MENÉNDEZ BUJÁN, Pablo , SANCHEZ MARTÍNEZ, Diego , BUENO UROZ, Clara , GUTIÉRREZ AGÜERA, Francisco , ROCA-HO, Heleia
IPC分类号： C07K14/725 , C07K16/28 , C12N5/0783 , A61P35/00 , A61K39/00
摘要： Relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) has a dismal outcome, and no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen receptor T-cells (CARTs) to T-ALL remains challenging because the shared expression of target antigens between CARTs and T-ALL blasts leads to CARTs fratricide. CD1a is exclusively expressed in cortical T-ALLs, a major subset of T-ALL. The expression of CD1a is restricted to cortical thymocytes and neither CD34+ progenitors nor T-cells express CD1a during ontogeny, confining the risk of on-target/off-tumor toxicity. The present invention provides CARs comprising a CD1a-targeting moiety which may be transduced or transformed into T cells. The resultant CARTs are suitable for the treatment of cortical T-ALLS.
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