公开(公告)号：EP3867363A1

公开(公告)日：2021-08-25

申请号：EP19786816.9

申请日：2019-10-18

申请人： Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) ,  Fundación Instituto de Investigación contra la Leucemia Josep Carreras (IJC)

发明人： RODRIGUEZ PERALES, Sandra ,  TORRES RUIZ, Raúl ,  MARTINEZ-LAGE, Marta

IPC分类号： C12N9/22 ,  A61K38/46 ,  A61K48/00 ,  C12N15/10 ,  C12N15/11 ,  C12N15/113 ,  C12N15/62 ,  A61P35/00

公开(公告)号：EP3640329A1

公开(公告)日：2020-04-22

申请号：EP18382746.8

申请日：2018-10-18

申请人： Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO)

发明人： RODRIGUEZ PERALES, Sandra ,  TORRES RUIZ, Raúl ,  MARTINEZ-LAGE, Marta

IPC分类号： C12N9/22 ,  A61K38/46 ,  A61K48/00 ,  C12N15/10 ,  C12N15/11 ,  C12N15/113 ,  C12N15/62 ,  A61P35/00

摘要： The present invention relates to a method for eliminating cancer cells, wherein said cells comprise a genomic rearrangement which leads either to the expression of a fusion gene not present in non-cancer cells, or to genomic amplifications or rearrangements which lead to the induction of the expression or to the overexpression of a cancer inducing gene, said method comprising: (a) cleaving the genome in at least two sites, said cleavage leading to either a deletion, an inversion, a frameshift and/or an insertion in the genome of said cancer cells, and/or (b) cleaving the expression product of said fusion gene or cancer inducing gene in at least one site.