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公开(公告)号：EP4454572A1
公开(公告)日：2024-10-30
申请号：EP22910260.3
申请日：2022-11-10
IPC分类号： A61B17/115
摘要： instrument for surgical stapling between a vascular prosthesis (94) and the aorta, comprising a handle (1) configured to give a tissue compression instruction and another anterolateral staple ejection instruction (5); a head (3) comprising a rotary magazine (20) housing the anterolateral staples (5) until use and from which they exit for stapling, a compression-decompression mechanism (45) for homogeneous compression of the tissues to be stapled, a firing mechanism (50) of the rotary magazine (20) for firing the anterolateral staples (5); a ring (4) with a cylindrical body (69) with an inner conduit (70), perimeter holes (72) for receiving the legs (6) of the anterolateral staples (5) and providing them with a B-shape, an anchoring port (44), and a stapling mechanism for the posterior aortic sector (80) with a stapling sheet (81) with a plurality of through holes (82).
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公开(公告)号：EP4437858A1
公开(公告)日：2024-10-02
申请号：EP23382313.7
申请日：2023-03-31
发明人： Kuligowski, Julia , Sepúlveda Sanchis, Pilar , Ten Doménech, Isabel , Gómez Ferrer, Marta , Albiach Delgado, Abel , Vento Torres, Máximo , Peiró Molina, Esteban
IPC分类号： A23L33/12 , A23L33/00 , A61K31/202 , A61P29/00
CPC分类号： A23L33/40 , A23L33/12 , A61K31/202 , A61P29/00
摘要： The present invention refers to a composition comprising a combination of oxylipins 14-HDHA, 17-HDHA, and 19,20-DiHDPA and, additionally, one or more oxylipins selected from the group consisting of 12,13-DiHOME; 9,10-DiHOME; 14,15-DiHETrE; PGE2; PGF2α; 17,18-DiHETE; 11,12-DiHETrE; 9-HOTrE; 20-HETE; 12(S)-HpETE; 12(S)-HEPE; 13-HODE; 5(S)-HEPE; 9-HODE; 15-HETE; 16(17)-EpDPE; 13-HpODE; 13-KODE; 9-HpODE; 15-HpETE; 15-KETE; 11-HETE; 9-KODE; 12-HETE; 8-HETE; 15(S)-HETrE; 9-HETE; 5-HETE; 19(20)-EpDPE; 12(13)-EpOME; 5(S)-HpETE; 9(10)-EpOME; 12-KETE; 5-KETE; 8(9)-EpETrE, and 5(6)-EpETrE. The invention refers to the use of this composition as nutritional suplemment. Finally, pharmaceutical compositions comprising this composition for the prevention and treatment of intestinal diseases are also contemplated.
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公开(公告)号：EP4292517A1
公开(公告)日：2023-12-20
申请号：EP22711253.9
申请日：2022-02-14
申请人： Fundación Para la Investigación del Hospital Universitario y Politécnico La Fe de la Comunidad Valenciana , Universitat Politècnica de València , Asociación Instituto de Biomecánica de Valencia , Consejo Superior de Investigaciones Científicas (CSIC)
发明人： VERA DONOSO, César David , BORONAT TORMO, Francisco de Paula , JIMÉNEZ GONZÁLEZ, Noé , CAMARENA FEMENÍA, Francisco , ATIENZA VICENTE, Carlos Manuel , MORAGA MAESTRE, Ramón
摘要： It consists of a system for palpation of the rectal face of the prostate that transforms the information collected into objective, reproducible and useful information. The system makes it possible to identify areas of high rigidity reaching the entire peripheral area, transforming a diagnostic maneuver for prostate cancer into an objective one, which until now has been subjective and unreliable. All this in a short space of time, carried out in a less aggressive and more objective way than rectal examination. The device consists of a manual electronic instrument with a handle (1) and a scanning rod (3), which includes at least two concentric force/pressure sensors of different heights, as well as an ultrasonic imaging system which, through means of connection to external devices for analysis/control, allows the data obtained to be analyzed and the anatomy of the prostate being analyzed to be visualized in real time.
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公开(公告)号：EP3566664A1
公开(公告)日：2019-11-13
申请号：EP18736597.8
申请日：2018-01-02
申请人： Universitat Politècnica de València , Fundación Para la Investigación del Hospital Universitario y Politécnico La Fe de la Comunidad Valenciana
发明人： PACE BEDETTI, Horacio Martín , CONEJERO RODILLA, Andrés , MARTÍNEZ DE JUAN, José Luis , DOLZ LAGO, José Francisco
IPC分类号： A61B17/29
摘要： The present invention describes a surgical tool that comprises a stylus, a point of the surgical tool at the distal end of the stylus, and a handle at the proximal end of the stylus which comprises means for actuating the point of the tool. The handle is formed by a ball joint comprising: a base hemisphere coupled to the stylus; a central hemisphere solidly connected to the base hemisphere and located at the centre thereof; a gripping clamp with a cylindrical inner surface concentric with the base hemisphere; a rotation hemisphere solidly connected to the gripping clamp and located at the centre thereof, forming a ball joint together with the central hemisphere; and locking means. The locking means allow a locking or unlocking position to be adopted, in which in relative movement between the gripping clamp and the base hemisphere is prevented or permitted, respectively.
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公开(公告)号：EP3402898A1
公开(公告)日：2018-11-21
申请号：EP17700918.0
申请日：2017-01-10
申请人： Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) , Fundación Para la Investigación del Hospital Universitario y Politécnico La Fe de la Comunidad Valenciana , Fundacion para la Investigacion Medica Aplicada
发明人： SANDOVAL DEL AMOR, Juan , MONTUENGA BADIA, Luís , DÍAZ LAGARES, Ángel , MÉNDEZ GONZÁLEZ, Jesús , HERVÁS MARÍN, David , ESTELLER BADOSA, Manel
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/172
摘要： The present invention refers to the field of cancer and, in particular, to an in vitro method for the diagnosis of lung cancer by determining in a biologicla sample, taken from a subject, the methylation level of particular genes. It further relates to biomarkers and kits useful for said method.
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6.发明公开Method for predicting response to continuous positive air pressure treatment 审中-公开Verfahren zur Vorhersage der Reaktion auf eine kontinuierliche positive Atemwegdruckbehandlung
公开(公告)号：EP3034623A1
公开(公告)日：2016-06-22
申请号：EP14382533.9
申请日：2014-12-18
申请人： Centro de Investigación Biomédica en Red (CIBER) , Institut de Recerca Biomèdica de Lleida Fundació Doctor Pifarré , Fundación Para la Investigación del Hospital Universitario y Politécnico La Fe de la Comunidad Valenciana
发明人： Barbé Illa, Eduard Ferran , Sánchez de la Torre, Manuel , Gozal, David , Khalyfa, Abdelnaby , Sánchez de la Torre, Alicia , Martinez García, Miguel Angel
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178
摘要： In vitro method for predicting the response to continuous positive airway pressure (CPAP) in a subject in need thereof, the method comprising determining in an isolated sample of the subject the level of expression of a cardiovascular system functionally related microRNA differentially expressed in patients with cardiovascular disease, said microRNA selected from the group consisting of miR.100.5p, miR.378a.3p, miR.486.5p, and combinations thereof.
摘要翻译： 用于预测有需要的受试者对持续气道正压（CPAP）的反应的体外方法，所述方法包括在受试者的分离样品中测定在患有心血管的患者中差异表达的心血管系统功能相关的微小RNA的表达水平 疾病，所述microRNA选自miR.100.5p，miR.378a.3p，miR.486.5p及其组合。
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公开(公告)号：EP4374904A2
公开(公告)日：2024-05-29
申请号：EP23214148.1
申请日：2020-09-12
申请人： Fundación Para la Investigación del Hospital Universitario y Politécnico La Fe de la Comunidad Valenciana , Fundación de la Comunidad Valenciana Hospital General para la Investigación Biomédica, Docencia y Desarrollo de las Ciencias de la Salud
IPC分类号： A61M16/16
CPC分类号： A61M13/003 , A61M13/006 , A61M16/161 , A61M16/16 , A61M2230/5020130101 , A61M2205/333420130101 , A61M2205/334420130101 , A61M2205/330620130101
摘要： The system comprises an intracavity device with an insertable portion having on its outer surface a sensor module which comprises at least a sensor of temperature, humidity or both; a second group of sensors comprising at least a volume sensor, a pressure sensor or both, wherein the fluid flows through the volume and/or pressure sensors; a fluid insufflation module; and a monitoring and control of the homeostasis module connected to the sensor module and to the second group of sensors and which comprises a processing unit.
The method comprises insufflating fluid into the cavity, to maintain a working volume and maintain the homeostasis of the cavity in a continuous manner, in particular the distensibility, temperature and humidity.-
公开(公告)号：EP4140410A1
公开(公告)日：2023-03-01
申请号：EP22195480.3
申请日：2021-03-15
发明人： ALBEROLA RUBIO, JOSÉ
摘要： A method of characterizing a uterine peristaltic activity pattern and a computer program product are provided.
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9.发明公开
公开(公告)号：EP4029496A1
公开(公告)日：2022-07-20
申请号：EP21382036.8
申请日：2021-01-18
申请人： Universitat de València , Fundación Para la Investigación del Hospital Universitario y Politécnico La Fe de la Comunidad Valenciana
发明人： Estrela Arigüel, José María , Obrador Pla, María Elena , Salvador Palmer, María Rosario , Montoro Pastor, Alegría
IPC分类号： A61K31/05 , A61K31/365 , A61P39/00 , A61P39/06
摘要： The present invention relates to compositions comprising Pterostilbene, or a pharmaceutically acceptable salt thereof, in combination with Silibinin, or a pharmaceutically acceptable salt thereof, and their use in the treatment, prevention, amelioration or reduction of diseases induced by ionizing radiation in a subject. The compositions and the uses can further comprise at least one or more radiomitigator compound/s, preferably NAD+ boosters and/or FSL-1.
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公开(公告)号：EP3234185B1
公开(公告)日：2020-04-08
申请号：EP15817217.1
申请日：2015-12-17
申请人： Centro de Investigación Biomédica en Red , Institut de Recerca Biomèdica de Lleida Fundació Doctor Pifarré , Fundación Para la Investigación del Hospital Universitario y Politécnico La Fe de la Comunidad Valenciana
发明人： BARBE ILLA, Eduard Ferran , SANCHEZ DE LA TORRE, Manuel , GOZAL, David , KHALYFA, Abdelnaby , SANCHEZ DE LA TORRE, Alicia , MARTINEZ GARCÍA, Miguel Ángel
IPC分类号： C12Q1/6883
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