公开(公告)号：EP4355733A1

公开(公告)日：2024-04-24

申请号：EP22733941.3

申请日：2022-06-15

申请人： Grünenthal GmbH

发明人： KRÜGER, Sebastian ,  KONETZKI, Ingo ,  SITNIKOV, Nikolay ,  YOUNG, Clint ,  HAGENDORF, Silke ,  ALEN, Jo ,  PETTERSSON, Martin ,  PEIL, Sebastian ,  DIALER, Clemens ,  MÜLBAIER, Marcel ,  WAGENER, Markus

IPC分类号： C07D231/14 ,  C07D231/20 ,  C07D401/12 ,  C07D405/06 ,  C07D405/14 ,  C07D493/08 ,  A61K31/4155 ,  A61K31/4439 ,  A61P29/00

CPC分类号： C07D231/14 ,  C07D231/20 ,  C07D401/12 ,  C07D405/06 ,  C07D405/14 ,  C07D493/08 ,  A61P29/00

公开(公告)号：EP3995135A1

公开(公告)日：2022-05-11

申请号：EP20206800.3

申请日：2020-11-10

申请人： Grünenthal GmbH

发明人： BERTRAM, Ulrike Dr. ,  REINHOLD, Ulrich Dr. ,  GROSSE, Christian Dr. ,  HARTMANN, Carmen

IPC分类号： A61K9/20 ,  A61K31/00

摘要： Die Erfindung betrifft eine Tablette, die eine verlängerte Freisetzung von Tapentadol bereitstellt, wobei Tapentadol in Form eines Salzes mit Weinsäure, insbesondere in Form eines Salzes mit L-(+)-Weinsäure vorliegt. Die Tablette hat zufriedenstellende mechanische Eigenschaften, z. B. im Hinblick auf Bruchfestigkeit und Friabilität, und lässt sich unter stark erleichterten Tablettierbedingungen, insbesondere bei verminderter Presskraft, herstellen.

公开(公告)号：EP3698776A1

公开(公告)日：2020-08-26

申请号：EP19157987.9

申请日：2019-02-19

申请人： Grünenthal GmbH

发明人： IMMOHR, Isabell ,  WENING. Klaus

IPC分类号： A61K9/14 ,  A61K9/20 ,  A61K31/00

摘要： The invention relates to a tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, preferably selected from opioids; a polyalkylene oxide having a weight average molecular weight within the range of from 200,000 g/mol to 2,000,000 g/mol, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 20 wt.-%, based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.

公开(公告)号：EP3685827A1

公开(公告)日：2020-07-29

申请号：EP20154395.6

申请日：2012-03-02

申请人： Grünenthal GmbH

发明人： REINHOLD, Ulrich ,  SCHILLER, Marc ,  WULSTEN, Eva ,  INGHELBRECHT, Sabine Karine Katrien ,  EMBRECHTS, Roger Carolus Augusta ,  FEIL, Ulrich

IPC分类号： A61K9/08 ,  A61K31/137 ,  A61K47/02 ,  A61K47/12 ,  A61P25/00 ,  A61P25/04 ,  A61K9/00

摘要： Summary:
The invention relates to an aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof and being adapted for oral administration. The composition has excellent storage stability without relying on the presence of high amounts of preservatives.

公开(公告)号：EP3402782B1

公开(公告)日：2020-07-29

申请号：EP17700390.2

申请日：2017-01-13

申请人： Grünenthal GmbH

发明人： KÜHNERT, Sven ,  KOENIGS, René Michael ,  KLESS, Achim ,  WEGERT, Anita ,  RATCLIFFE, Paul ,  JOSTOCK, Ruth ,  KOCH, Thomas ,  LINZ, Klaus ,  SCHRÖDER, Wolfgang

IPC分类号： C07D235/02 ,  A61K31/4166 ,  A61P25/00

公开(公告)号：EP3295935B1

公开(公告)日：2020-07-22

申请号：EP17180990.8

申请日：2010-07-30

申请人： Grünenthal GmbH

发明人： HANNA, Mazen ,  SHAN, Ning ,  CHENEY, Miranda ,  WEYNA, David ,  HOUCK, Raymond, K.

IPC分类号： A61K9/22 ,  A61K31/66

公开(公告)号：EP3656765A1

公开(公告)日：2020-05-27

申请号：EP19214275.0

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07D275/06 ,  C07D291/06 ,  C07C215/54 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

公开(公告)号：EP3287123B1

公开(公告)日：2020-04-22

申请号：EP17189271.4

申请日：2012-03-02

申请人： Grünenthal GmbH

发明人： REINHOLD, Ulrich ,  SCHILLER, Marc ,  WULSTEN, Eva Cornelia ,  INGHELBRECHT, Sabine Karine Katrien ,  EMBRECHTS, Roger Carolus Augusta ,  FEIL, Ulrich

IPC分类号： A61P25/04 ,  A61K9/08 ,  A61K47/02 ,  A61K47/12 ,  A61K31/137

公开(公告)号：EP3636629A1

公开(公告)日：2020-04-15

申请号：EP19206638.9

申请日：2011-07-22

申请人： Grünenthal GmbH

发明人： GRUSS, Michael ,  KRASZEWSKI, Magda

IPC分类号： C07C215/54 ,  C07D275/06 ,  C07D291/06 ,  A61K31/137 ,  C07D239/545 ,  C07C59/255

摘要： The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

公开(公告)号：EP3630074A1

公开(公告)日：2020-04-08

申请号：EP18727301.6

申请日：2018-05-29

申请人： Grünenthal GmbH

发明人： SCHILLER, Marc ,  REINHOLD, Ulrich ,  BERTRAM, Ulrike ,  PRANGE, Wolfgang ,  PHILIPP, Anika-Anina ,  STRAUB, Stefanie ,  GRAVE, Annette ,  POELLINGER, Norbert

IPC分类号： A61K9/50 ,  A61K31/137