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    BROWN ADIPOCYTE PROGENITORS IN HUMAN SKELETAL MUSCLE
    1.
    发明公开
    BROWN ADIPOCYTE PROGENITORS IN HUMAN SKELETAL MUSCLE 有权
    布朗PRE脂肪细胞人类骨骼肌肉

    公开(公告)号：EP2296478A1

    公开(公告)日：2011-03-23

    申请号：EP09762837.4

    申请日：2009-05-27

    申请人： Boss, Olivier D. ,  Giacobino, Jean-Paul

    发明人： Boss, Olivier D. ,  Giacobino, Jean-Paul

    IPC分类号： A01N65/00 ,  G01N33/53 ,  C12N5/00

    CPC分类号： A61K31/4439 ,  C12N5/0653 ,  C12N5/0667 ,  C12N2501/01 ,  C12N2501/385 ,  C12N2501/999 ,  C12N2503/02 ,  C12N2506/13 ,  G01N33/5023 ,  G01N33/5044 ,  G01N2800/04 ,  G01N2800/042

    摘要： Brown adipose tissue ("BAT") progenitor cells and methods for identifying BAT progenitor cells in a population of cells are provided. Methods are also provided for inducing differentiation of BAT progenitor cells into differentiated brown adipocytes, inducing expression or increased activity levels of BAT uncoupling protein-1 ("UCP1"), and for identifying agents capable of inducing differentiation of BAT progenitor cells into brown adipocytes and/or inducing expression or increased activity levels of UCP1. Differentiated brown adipocytes and agents and methods for inducing differentiation of BAT progenitor cells can be used for treatment of, or the making of medicaments for the treatment of, metabolic diseases or conditions in a patient such as obesity, overweight, impaired glucose tolerance, insulin-resistance, type 2 diabetes, dyslipidemia, hypertension, cardiovascular diseases, metabolic syndrome, and the like. Differentiated brown adipocytes and agents and methods for inducing differentiation of BAT progenitor cells can be used for prevention of hypothermia.

    BROWN ADIPOCYTE PROGENITORS IN HUMAN SKELETAL MUSCLE
    4.
    发明公开
    BROWN ADIPOCYTE PROGENITORS IN HUMAN SKELETAL MUSCLE 审中-公开
    人类骨骼肌中褐色脂肪细胞分化祖细胞

    公开(公告)号：EP2776557A1

    公开(公告)日：2014-09-17

    申请号：EP12847316.2

    申请日：2012-11-09

    申请人： Energesis Pharmaceuticals Inc. ,  Boss, Olivier D. ,  Crisan, Mihaela ,  Giacobino, Jean-Paul

    发明人： BOSS, Olivier D. ,  CRISAN, Mihaela ,  GIACOBINO, Jean-Paul

    IPC分类号： C12N5/00 ,  G01N33/48

    CPC分类号： C12N5/0653 ,  A61K35/35 ,  C12N2501/155 ,  C12N2501/40 ,  G01N33/56966 ,  G01N2333/70503 ,  G01N2333/70589 ,  G01N2333/70596

    摘要： This invention relates to brown adipose tissue (BAT) progenitor cells and methods for isolating BAT progenitor cells from skeletal muscle. BAT progenitor cell surface markers and medium and agents for inducing cell differentiation into brown adipocytes are also provided. In some embodiments, the BAT progenitor cell expresses a first cell surface marker associated with endothelial cells, the first cell surface marker being detectable in an antibody based assay using a first antibody. In addition, the BAT progenitor cell can be substantially free of a second cell surface marker associated with endothelial cells, the second cell surface marker being substantially undetectable in said antibody based assay using a second antibody. The BAT progenitor cell can also be substantially free of additional cell surface markers.

    摘要翻译： 本发明涉及棕色脂肪组织（BAT）祖细胞和从骨骼肌分离BAT祖细胞的方法。 还提供了BAT祖细胞表面标记和培养基以及诱导细胞分化成棕色脂肪细胞的试剂。 在一些实施方案中，BAT祖细胞表达与内皮细胞相关的第一细胞表面标记，第一细胞表面标记在使用第一抗体的基于抗体的测定中可检测。 此外，BAT祖细胞可以基本上不含与内皮细胞相关的第二种细胞表面标记，第二种细胞表面标记在使用第二种抗体的所述基于抗体的测定中基本上不可检测。 BAT祖细胞也可以基本上不含额外的细胞表面标记。