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公开(公告)号：EP3943092A3
公开(公告)日：2022-05-04
申请号：EP21193195.1
申请日：2015-02-24
IPC分类号： A61K35/35 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/22 , A61K31/05 , A61K31/165 , A61K31/166 , A61K31/195 , A61K31/352 , A61K31/426 , A61K31/4375 , A61K31/4422 , A61K31/475 , A61K31/4965 , A61K31/506 , A61K31/5415 , A61K31/5575 , A61K31/603 , C12N5/077
摘要： This disclosure relates to compositions and methods for recruiting brown adipocytes in vitro from brown adipocyte progenitor cells found in human skeletal muscle. Said compositions for use in methods for treating metabolic disease are also provided. In some embodiments, the brown adipocyte recruiter is a human protein or peptide. In other embodiments the brown adipocyte recruiter may be a non-human protein or peptide. In still other embodiments, the brown adipocyte recruiter is a small molecule or natural product.
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公开(公告)号：EP4208188A1
公开(公告)日：2023-07-12
申请号：EP21859105.5
申请日：2021-08-19
发明人： BOSS, Olivier , FREEMAN, Brian
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公开(公告)号：EP4340824A1
公开(公告)日：2024-03-27
申请号：EP22805598.4
申请日：2022-05-20
发明人： BOSS, Olivier D. , FREEMAN, Brian
IPC分类号： A61K31/025 , A61K31/19 , A61P3/06 , A61P3/10
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4.发明公开METHODS AND COMPOSITIONS FOR INDUCING DIFFERENTIATION OF HUMAN BROWN ADIPOCYTE PROGENITORS 审中-公开方法和组合物诱导脂肪细胞分化前体人类BROWN
公开(公告)号：EP3110946A1
公开(公告)日：2017-01-04
申请号：EP15752698.9
申请日：2015-02-24
IPC分类号： C12N5/0775 , A61K35/35
CPC分类号： A61K35/35 , A61K31/05 , A61K31/165 , A61K31/166 , A61K31/195 , A61K31/352 , A61K31/426 , A61K31/4375 , A61K31/4422 , A61K31/475 , A61K31/4965 , A61K31/506 , A61K31/5415 , A61K31/5575 , A61K31/603 , A61K38/1825 , A61K38/195 , A61K38/204 , A61K38/2242 , C12N5/0653 , C12N2503/02
摘要： This disclosure relates to compositions and methods for recruiting brown adipocytes in vitro and in vivo from brown adipocyte progenitor cells found in human skeletal muscle. Methods for treating metabolic disease are also provided. Additionally, methods for treating hypothermia are provided. In some embodiments, the brown adipocyte recruiter is a human protein or peptide. In other embodiments the brown adipocyte recruiter may be a non-human protein or peptide. In still other embodiments, the brown adipocyte recruiter is a small molecule or natural product.
摘要翻译： 本公开涉及组合物和方法用于招募在体外和在从人骨骼肌中发现褐色脂肪细胞祖细胞的体内褐色脂肪细胞。 因此，提供了用于治疗代谢性疾病的方法。 此外，提供了用于治疗低体温的方法。 在一些实施方案中，褐色脂肪细胞招募者是人蛋白质或肽。 在其它实施方案中，褐色脂肪细胞招募者可以是非人类蛋白质或肽。 在安静其它实施例中，褐色脂肪细胞招募者是小分子或天然产物。
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公开(公告)号：EP4149962A1
公开(公告)日：2023-03-22
申请号：EP21803999.8
申请日：2021-05-11
发明人： FREEMAN, Brian , BOSS, Olivier, D.
IPC分类号： C07K14/495 , A61K48/00 , C07K14/51
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公开(公告)号：EP3943092A2
公开(公告)日：2022-01-26
申请号：EP21193195.1
申请日：2015-02-24
IPC分类号： A61K35/35 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/22 , A61K31/05 , A61K31/165 , A61K31/166 , A61K31/195 , A61K31/352 , A61K31/426 , A61K31/4375 , A61K31/4422 , A61K31/475 , A61K31/4965 , A61K31/506 , A61K31/5415 , A61K31/5575 , A61K31/603 , C12N5/077
摘要： This disclosure relates to compositions and methods for recruiting brown adipocytes in vitro from brown adipocyte progenitor cells found in human skeletal muscle. Said compositions for use in methods for treating metabolic disease are also provided. In some embodiments, the brown adipocyte recruiter is a human protein or peptide. In other embodiments the brown adipocyte recruiter may be a non-human protein or peptide. In still other embodiments, the brown adipocyte recruiter is a small molecule or natural product.
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7.发明公开METHODS AND COMPOSITIONS FOR INDUCING DIFFERENTIATION OF HUMAN BROWN ADIPOCYTE PROGENITORS 审中-公开VERFAHREN UND ZUSAMMENSETZUNGEN ZUR INDUZIERUNG DER DIFFERENZIERUNG VONVORLÄUFERNMENSCHLICHER BRAUNER ADIPOZYTEN
公开(公告)号：EP3110946A4
公开(公告)日：2017-07-19
申请号：EP15752698
申请日：2015-02-24
发明人： BOSS OLIVIER B , GULLICKSEN P SCOTT
IPC分类号： A61K35/35 , A61K31/05 , A61K31/165 , A61K31/166 , A61K31/195 , A61K31/352 , A61K31/426 , A61K31/4375 , A61K31/4422 , A61K31/475 , A61K31/4965 , A61K31/506 , A61K31/5415 , A61K31/5575 , A61K31/603 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/22 , C12N5/077
CPC分类号： A61K35/35 , A61K31/05 , A61K31/165 , A61K31/166 , A61K31/195 , A61K31/352 , A61K31/426 , A61K31/4375 , A61K31/4422 , A61K31/475 , A61K31/4965 , A61K31/506 , A61K31/5415 , A61K31/5575 , A61K31/603 , A61K38/1825 , A61K38/195 , A61K38/204 , A61K38/2242 , C12N5/0653 , C12N2503/02
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公开(公告)号：EP2776557A4
公开(公告)日：2015-04-08
申请号：EP12847316
申请日：2012-11-09
IPC分类号： C12N5/077 , C12N5/0775 , G01N33/569
CPC分类号： C12N5/0653 , A61K35/35 , C12N2501/155 , C12N2501/40 , G01N33/56966 , G01N2333/70503 , G01N2333/70589 , G01N2333/70596
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公开(公告)号：EP2776557A1
公开(公告)日：2014-09-17
申请号：EP12847316.2
申请日：2012-11-09
CPC分类号： C12N5/0653 , A61K35/35 , C12N2501/155 , C12N2501/40 , G01N33/56966 , G01N2333/70503 , G01N2333/70589 , G01N2333/70596
摘要： This invention relates to brown adipose tissue (BAT) progenitor cells and methods for isolating BAT progenitor cells from skeletal muscle. BAT progenitor cell surface markers and medium and agents for inducing cell differentiation into brown adipocytes are also provided. In some embodiments, the BAT progenitor cell expresses a first cell surface marker associated with endothelial cells, the first cell surface marker being detectable in an antibody based assay using a first antibody. In addition, the BAT progenitor cell can be substantially free of a second cell surface marker associated with endothelial cells, the second cell surface marker being substantially undetectable in said antibody based assay using a second antibody. The BAT progenitor cell can also be substantially free of additional cell surface markers.
摘要翻译： 本发明涉及棕色脂肪组织（BAT）祖细胞和从骨骼肌分离BAT祖细胞的方法。 还提供了BAT祖细胞表面标记和培养基以及诱导细胞分化成棕色脂肪细胞的试剂。 在一些实施方案中，BAT祖细胞表达与内皮细胞相关的第一细胞表面标记，第一细胞表面标记在使用第一抗体的基于抗体的测定中可检测。 此外，BAT祖细胞可以基本上不含与内皮细胞相关的第二种细胞表面标记，第二种细胞表面标记在使用第二种抗体的所述基于抗体的测定中基本上不可检测。 BAT祖细胞也可以基本上不含额外的细胞表面标记。
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