专利检索 ap:"Goodfellow, Valerie Joy" 第 1 页

1.

发明公开
CEPHALOSPORIN DERIVATIVES USEFUL AS -LACTAMASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：作为β-内酰胺酶抑制剂的头孢类衍生物及其组合物及其使用方法

公开(公告)号：EP2539348A4

公开(公告)日：2013-07-24

申请号：EP11746805

申请日：2011-02-25

申请人： DMITRIENKO GARY IGOR , GHAVAMI AHMAD , GOODFELLOW VALERIE JOY , JOHNSON JARROD W , KRISMANICH ANTHONY PAUL , MARRONE LAURA , VISWANATHA SUNDARAMMA

发明人： DMITRIENKO GARY IGOR , GHAVAMI AHMAD , GOODFELLOW VALERIE JOY , JOHNSON JARROD W , KRISMANICH ANTHONY PAUL , MARRONE LAURA , VISWANATHA THAMMAIAH

IPC分类号： C07D501/36 , A61K31/545 , A61P31/04 , C07D501/26 , C07D501/28

CPC分类号： C07D501/36 , A61K31/545 , C07D501/26 , C07D501/28

摘要： The present invention relates to cephalosporin derivatives having &bgr;-lactamase inhibitory activity. The compounds are useful in preventing or treating bacterial resistance to an antibiotic, e.g. a &bgr;-lactam antibiotic. Disclosed herein are compounds that are inhibitors of class B metallo-&bgr;-lactamases, as well as class A, C, and D serine &bgr;-lactamases. In some preferred embodiments, the compounds are 3′-thiobenzoate derivatives of a cephalosporin. Pharmaceutical compositions, methods, uses, kits and commercial packages comprising the compounds are also disclosed.

2.

发明公开
CEPHALOSPORIN DERIVATIVES USEFUL AS -LACTAMASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：头孢菌素以β-内酰胺酶抑制剂和组成，并且PROPER申请流程。

公开(公告)号：EP2539348A1

公开(公告)日：2013-01-02

申请号：EP11746805.8

申请日：2011-02-25

申请人： Dmitrienko, Gary Igor , Ghavami, Ahmad , Goodfellow, Valerie Joy , Johnson, Jarrod W. , Krismanich, Anthony Paul , Marrone, Laura , Viswanatha, Sundaramma

发明人： DMITRIENKO, Gary Igor , GHAVAMI, Ahmad , GOODFELLOW, Valerie Joy , JOHNSON, Jarrod W. , KRISMANICH, Anthony Paul , MARRONE, Laura , VISWANATHA, Thammaiah

IPC分类号： C07D501/36 , A61K31/545 , A61P31/04

CPC分类号： C07D501/36 , A61K31/545 , C07D501/26 , C07D501/28 , Y02A50/47 , Y02A50/471 , Y02A50/475 , Y02A50/481 , Y02A50/483

摘要： The present invention relates to cephalosporin derivatives having &bgr;-lactamase inhibitory activity. The compounds are useful in preventing or treating bacterial resistance to an antibiotic, e.g. a &bgr;-lactam antibiotic. Disclosed herein are compounds that are inhibitors of class B metallo-&bgr;-lactamases, as well as class A, C, and D serine &bgr;-lactamases. In some preferred embodiments, the compounds are 3′-thiobenzoate derivatives of a cephalosporin. Pharmaceutical compositions, methods, uses, kits and commercial packages comprising the compounds are also disclosed.