公开(公告)号：EP1227821A1

公开(公告)日：2002-08-07

申请号：EP00979164.1

申请日：2000-11-13

申请人： HODOSH, Milton

发明人： HODOSH, Milton

IPC分类号： A61K33/00 ,  A61K31/34 ,  A61K31/24 ,  A61K31/19 ,  A61K31/195

CPC分类号： A61K9/0014 ,  A61K31/167 ,  A61K31/192 ,  A61K31/245 ,  A61K31/353 ,  A61K31/573 ,  A61K31/593 ,  A61K33/00 ,  A61K47/26 ,  A61K2300/00 ,  A61K31/34

摘要： A therapeutic composition and a method of using the composition are provided. The composition includes an osmotic agent and an active agent. The osmotic agent improves the delivery of the active agent to the targeted tissue site.

公开(公告)号：EP0788343A4

公开(公告)日：2000-09-06

申请号：EP95938921

申请日：1995-10-26

申请人： HODOSH MILTON

发明人： HODOSH MILTON

IPC分类号： A61K6/00 ,  A61K8/19 ,  A61Q11/00 ,  A61K6/08 ,  A61C5/02 ,  A61K7/16

CPC分类号： A61Q11/00 ,  A61K6/0032 ,  A61K8/19 ,  Y10S514/817 ,  Y10S514/818

摘要： The present invention is directed to a method for anesthetizing teeth which does not require an injection into the gum in order to anesthetize a tooth (or teeth) which requires attention. The method comprises the step of applying a composition having a high concentration of potassium to a tooth requiring caries removal or manual manipulation thereof. The composition is adapted to anesthetize the tooth so that the tooth may be drilled or manually manipulated. It has been discovered that the potassium enters the dentinal tubules and odontoblastic fibrils and penetrates the pulpal tissues of the tooth for anesthetizing the tooth without having to inject anesthetics into the gum surrounding the tooth.

公开(公告)号：EP1227821A4

公开(公告)日：2004-09-22

申请号：EP00979164

申请日：2000-11-13

申请人： HODOSH MILTON

发明人： HODOSH MILTON

IPC分类号： A61K47/22 ,  A61K6/00 ,  A61K9/00 ,  A61K31/167 ,  A61K31/19 ,  A61K31/192 ,  A61K31/194 ,  A61K31/245 ,  A61K31/34 ,  A61K31/341 ,  A61K31/353 ,  A61K31/573 ,  A61K31/59 ,  A61K31/593 ,  A61K33/00 ,  A61K33/04 ,  A61K33/10 ,  A61K33/14 ,  A61K33/16 ,  A61K33/18 ,  A61K33/24 ,  A61K33/42 ,  A61K38/35 ,  A61K45/08 ,  A61K47/26 ,  A61P1/02 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61K31/195 ,  A61K31/24

CPC分类号： A61K9/0014 ,  A61K31/167 ,  A61K31/192 ,  A61K31/245 ,  A61K31/353 ,  A61K31/573 ,  A61K31/593 ,  A61K33/00 ,  A61K47/26 ,  A61K2300/00 ,  A61K31/34

公开(公告)号：EP0788343A1

公开(公告)日：1997-08-13

申请号：EP95938921.0

申请日：1995-10-26

申请人： HODOSH, Milton

发明人： HODOSH, Milton

IPC分类号： A61K6 ,  A61K8 ,  A61Q11

CPC分类号： A61Q11/00 ,  A61K6/0032 ,  A61K8/19 ,  Y10S514/817 ,  Y10S514/818

摘要： The present invention is directed to a method for anesthetizing teeth which does not require an injection into the gum in order to anesthetize a tooth (or teeth) which requires attention. The method comprises the step of applying a composition having a high concentration of potassium to a tooth requiring caries removal or manual manipulation thereof. The composition is adapted to anesthetize the tooth so that the tooth may be drilled or manually manipulated. It has been discovered that the potassium enters the dentinal tubules and odontoblastic fibrils and penetrates the pulpal tissues of the tooth for anesthetizing the tooth without having to inject anesthetics into the gum surrounding the tooth.