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公开(公告)号：EP4385998A1
公开(公告)日：2024-06-19
申请号：EP22848550.4
申请日：2022-07-27
发明人： WU, Gang , LU, Yunyu , WU, Liyong , CHENG, Liuxingxing , LEI, Xiaoxuan
IPC分类号： C07K14/00 , C07K7/56 , C07K7/08 , C07K7/06 , C07K1/04 , C07K1/107 , C07K1/34 , C07K1/14 , A61K38/16 , A61K38/10 , A61K38/08 , A61P17/02 , A61P17/16
CPC分类号： A61K38/10 , A61K38/16 , A61K38/08 , A61P17/02 , A61P17/16 , C07K1/04 , C07K1/14 , C07K1/107 , C07K1/34 , C07K7/06 , C07K7/08 , C07K7/56 , C07K14/00
摘要： The present invention provides a cyclic peptide, and a preparation method and use thereof. The cyclic peptide is a series of head-to-tail cyclic peptides or N-terminal and C-terminal cyclized peptides with triazole rings, which are prepared by an azido-alkyne cycloaddition reaction of the whole sequence of linear histamine or the truncated sequence of a linear Hst1 under specific conditions; where the biological activity of the full-sequence head-to-tail cyclic peptide or N-terminal and C-terminal cyclized peptide is increased by more than 1,000 times compared with that of the linear histamine, can significantly improve a dose-effect ratio and clinical efficacy of the histamine over the existing histamine cyclic peptide; the head-to-tail cyclic peptides or N-terminal and C-terminal cyclized peptides of the truncated sequence of the Hst1 has a molecular weight which is only 1/3 of that of the linear Hst1, biological activity that is 15 times that of the linear Hst1, and the cost for achieving the same activity that is only 1/100 of that of the linear Hst1. The entire cyclization process is gentle, simple, convenient and efficient, and can produce high-purity head-to-tail cyclic peptides or N-terminal and C-terminal cyclized peptides, can be used for preparing anti-aging and repairing skin care products, health care products, or medicines, and has a very good prospect for large-scale industrialization.
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公开(公告)号：EP4316536A1
公开(公告)日：2024-02-07
申请号：EP21933939.7
申请日：2021-04-01
发明人： WU, Gang , WU, Li Yong , LU, Yun Yu
摘要： The present disclosure provides an efficient biphasic calcium phosphate coating method. A high-concentration (4.5x) supersaturated calcium phosphate solution (SCPS) is used for coating and a thicker continuous coating is formed on a titanium disc. Besides, the coating contains dicalcium phosphate dihydrate and hydroxyapatite. The coating has an obviously improved encapsulation efficiency of a protein FITC-BSA and releases less Ca 2+ under an acidic condition. At the same time, a more efficient coating with a high yield and a protein encapsulation efficiency can be obtained with a less SCPS solution volume and a shorter coating time, such that a cost is greatly reduced in clinical application and the coating is very expected to be used in an osteogenic implant material in the biomedical field.
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公开(公告)号：EP4279081A1
公开(公告)日：2023-11-22
申请号：EP21927342.2
申请日：2021-03-01
发明人： WU, Gang , WU, Liyong , FENG, Jianying , SHI, Changjin , DU, Yiyang , LU, Yunyu , YAO, Yu , GUO, Jing
摘要： Disclosed is use of a Histatin-1 polypeptide in promotion of cartilage regeneration or repair. By preparing a combined reagent containing a Histatin-1 polypeptide, a biological scaffold material and the like, mainly a linear Hst1 is loaded on gelatin methacrylate so as to be used for repairing cartilage damage or promoting cartilage growth; meanwhile, disclosed is use of a Histatin-1 polypeptide in promotion of the expression of one or more of bone differentiation indexes, including a collagen fiber, glycosaminoglycan, type II collagen and aggrecan.
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