公开(公告)号：EP4385998A1

公开(公告)日：2024-06-19

申请号：EP22848550.4

申请日：2022-07-27

申请人： Hangzhou Huibo Science and Technology Co., Ltd

发明人： WU, Gang ,  LU, Yunyu ,  WU, Liyong ,  CHENG, Liuxingxing ,  LEI, Xiaoxuan

IPC分类号： C07K14/00 ,  C07K7/56 ,  C07K7/08 ,  C07K7/06 ,  C07K1/04 ,  C07K1/107 ,  C07K1/34 ,  C07K1/14 ,  A61K38/16 ,  A61K38/10 ,  A61K38/08 ,  A61P17/02 ,  A61P17/16

CPC分类号： A61K38/10 ,  A61K38/16 ,  A61K38/08 ,  A61P17/02 ,  A61P17/16 ,  C07K1/04 ,  C07K1/14 ,  C07K1/107 ,  C07K1/34 ,  C07K7/06 ,  C07K7/08 ,  C07K7/56 ,  C07K14/00

摘要： The present invention provides a cyclic peptide, and a preparation method and use thereof. The cyclic peptide is a series of head-to-tail cyclic peptides or N-terminal and C-terminal cyclized peptides with triazole rings, which are prepared by an azido-alkyne cycloaddition reaction of the whole sequence of linear histamine or the truncated sequence of a linear Hst1 under specific conditions; where the biological activity of the full-sequence head-to-tail cyclic peptide or N-terminal and C-terminal cyclized peptide is increased by more than 1,000 times compared with that of the linear histamine, can significantly improve a dose-effect ratio and clinical efficacy of the histamine over the existing histamine cyclic peptide; the head-to-tail cyclic peptides or N-terminal and C-terminal cyclized peptides of the truncated sequence of the Hst1 has a molecular weight which is only 1/3 of that of the linear Hst1, biological activity that is 15 times that of the linear Hst1, and the cost for achieving the same activity that is only 1/100 of that of the linear Hst1. The entire cyclization process is gentle, simple, convenient and efficient, and can produce high-purity head-to-tail cyclic peptides or N-terminal and C-terminal cyclized peptides, can be used for preparing anti-aging and repairing skin care products, health care products, or medicines, and has a very good prospect for large-scale industrialization.