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公开(公告)号：EP3708561A2
公开(公告)日：2020-09-16
申请号：EP18872534.5
申请日：2018-11-06
发明人： JUNG, Yong Gyu , KWON, Bo Sung , KWAK, Seung Hwan , PARK, Eun Rang , KIM, Kyung Do , YUN, Hyun Sik , LEE, Hyung Woo , CHO, Young Bum
IPC分类号： C07C217/76 , C07C213/08 , C07C315/02 , C07C317/18 , C07C303/28 , C07C303/42 , C07C309/68 , C08G65/333
摘要： The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol derivative which can be utilized in various ways as a drug linker, and is appropriate and effective for mass production and is advantageous in reproducible mass production of high-quality products.
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公开(公告)号：EP3421521A1
公开(公告)日：2019-01-02
申请号：EP17756781.5
申请日：2017-02-21
发明人： KIM, Yu Rim , PARK, Eun Rang , KWON, Bo Sung , CHO, Young Bum , CHU, Jun Ho
IPC分类号： C08G65/332 , C08G65/48 , A61K31/11
CPC分类号： C08G65/331 , A61K31/11 , A61K47/60 , C08G65/3312 , C08G65/3346 , C08G65/48 , C08K5/07
摘要： The present invention relates to an improved method for preparing a high purity polyethylene glycol dialdehyde derivative. The preparation method can provide the polyethylene glycol dialdehyde derivative suitable as a raw material for pharmaceuticals because of high purity and terminal activity, by using PEG-diacetal, which is prepared by reacting polyethyleneglycol methanesulfonate with dialkoxy-1-propanol, as an intermediate.
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公开(公告)号：EP3421521B1
公开(公告)日：2020-04-08
申请号：EP17756781.5
申请日：2017-02-21
发明人： KIM, Yu Rim , PARK, Eun Rang , KWON, Bo Sung , CHO, Young Bum , CHU, Jun Ho
IPC分类号： C08G65/332 , C08G65/48 , A61K31/11 , C08G65/331 , C08G65/334 , A61K47/60
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公开(公告)号：EP4215565A1
公开(公告)日：2023-07-26
申请号：EP21869753.0
申请日：2021-09-16
发明人： MOON, Ji Hye , JANG, Yeon Jeong , SHIM, Hyun Jung , KIM, Eun Hye , EOM, Tae In , LEE, Su Mi , KIM, Yu Rim , JUNG, Yong Gyu , KIM, Ji Hye , AHN, Soon Ah , YOO, Wok Chul , CHO, Young Bum , LEE, Kyoung Min , LEE, Jae Heon
IPC分类号： C08G65/331 , A61K47/60 , A61K38/16
摘要： A polyethylene glycol derivative compound is represented by Formula 1 described in the detailed description. In Formula 1, n is a natural number of 30 to 115, and R 1 and R 2 are C 1 to C 5 alkyl that are identical to or different from each other.
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5.发明公开
公开(公告)号：EP3939990A1
公开(公告)日：2022-01-19
申请号：EP20756094.7
申请日：2020-02-14
发明人： CHOI, Wonkyoung , KIM, Nari , PARK, Jonghwan , PARK, Sungjun , KIM, Namdu , CHO, Youngbum
摘要： The present invention relates to a novel intermediate used for physiologically active polypeptides and a method for preparing the same. The novel intermediate may be effectively used as an intermediate for the preparation of physiologically active polypeptide pharmaceuticals, and may be efficiently used for the preparation of high-quality pharmaceuticals by providing a polypeptide intermediate of high yield and high purity.
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公开(公告)号：EP4397668A1
公开(公告)日：2024-07-10
申请号：EP22865053.7
申请日：2022-08-31
发明人： CHOI, Bo Sung , KIM, Na Ri , NOH, Jin Mi , JUNG, Yong Gyu , MIN, Su Hyeon
IPC分类号： C07H21/00 , C12N15/113 , A61K31/7088
CPC分类号： A61K31/7088 , A61K48/00 , C07H1/00 , C07H19/16 , C07H21/00 , C12N15/11 , C12N15/113
摘要： One aspect relates to a compound of Formula 1, a method of preparing an intermediate thereof, a cap analog including the same, an mRNA 5'-capped with the cap analog, a method of preparing mRNA using the cap analog, use for using the cap analog in preparing mRNA, and a pharmaceutical composition for expressing a target peptide or protein, including the mRNA 5'-capped with the cap analog, and the like.
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