公开(公告)号：EP4043433B1

公开(公告)日：2024-03-20

申请号：EP20867884.7

申请日：2020-09-17

发明人： CAO, Gejin ,  FAN, Weizhen ,  FAN, Chaojun ,  XU, Lei ,  XIN, Yong ,  ZHAO, Jingwei

IPC分类号： C07C303/28 ,  C07C309/65 ,  H01M10/0567 ,  C07C303/22 ,  C07C305/26

公开(公告)号：EP3530648B1

公开(公告)日：2023-11-08

申请号：EP18198896.5

申请日：2007-12-17

发明人： TOYAMA, Masahito ,  HAYASHI, Akio

IPC分类号： C07C303/28 ,  C07C303/44 ,  C07C309/65 ,  A61K51/00 ,  C07B59/00 ,  G01T1/161 ,  C07C309/73 ,  G21H5/02

公开(公告)号：EP4212509A1

公开(公告)日：2023-07-19

申请号：EP21865739.3

申请日：2021-08-04

申请人： Beijing Honghui Meditech Co., Ltd

发明人： ZHANG, Pingping ,  LIU, Ye ,  YU, Guokun ,  ZHAO, Qiangfeng

IPC分类号： C07C201/12 ,  C07C205/23 ,  C07C303/30 ,  C07C309/75 ,  C07C303/28 ,  C07C213/02 ,  C07C215/78 ,  C07C231/12 ,  C07C237/08 ,  C07C269/06 ,  C07C271/22

摘要： The present disclosure provides preparation method for water-soluble magnolol derivatives and honokiol derivatives and intermediates thereof, and related monohydroxy protection intermediates. The nitrification intermediate has a structure shown in Formula I. Formula I is

R 2 is a hydroxyl, and R 3 is H; or, R 2 is H, and R 3 is a hydroxyl; and R 1 and R 4 are independently selected from C 1 ~C 12 electron donor groups. The preparation method includes the following steps: performing monohydroxy protection on a compound A

with a hydroxy protection reagent in the presence of an acid binding agent to form a monohydroxy protection compound, herein R 1 , R 2 , R 3 and R 4 in the compound A have the same definition as above, and the hydroxy protection reagent is p-toluenesulfonyl chloride and 1-hydroxybenzotriazole; and performing a nitrification reaction and a deprotection reaction on the monohydroxy protection compound successively to obtain the nitrification intermediate. The present disclosure effectively improves the synthesis efficiency of the water-soluble magnolol derivative and honokiol derivative.

公开(公告)号：EP4163284A1

公开(公告)日：2023-04-12

申请号：EP22195446.4

申请日：2016-07-21

申请人： ImmunoGen, Inc.

发明人： GÉRARD, Baudouin ,  SHIZUKA, Manami ,  MILLER, Michael Louis ,  SILVA, Richard A.

IPC分类号： C07D487/04 ,  C07C303/28

摘要： The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

公开(公告)号：EP3265439B1

公开(公告)日：2019-03-27

申请号：EP16706865.9

申请日：2016-02-29

申请人： Bayer CropScience Aktiengesellschaft

发明人： BRUECHNER, Peter ,  HIMMLER, Thomas ,  PAZENOK, Sergii ,  FORD, Mark James

IPC分类号： C07C67/14 ,  C07C67/287 ,  C07C68/02 ,  C07C68/06 ,  C07C37/00 ,  C07C69/63 ,  C07C39/24 ,  C07C45/43 ,  C07C69/96 ,  C07C37/20 ,  C07C309/66 ,  C07C39/28 ,  C07C47/565 ,  C07C303/28

公开(公告)号：EP2128130B1

公开(公告)日：2018-10-10

申请号：EP07850708.4

申请日：2007-12-17

申请人： Nihon Medi-Physics Co., Ltd.

发明人： TOYAMA, Masahito ,  HAYASHI, Akio

IPC分类号： C07C303/28 ,  C07C303/44 ,  C07C309/65 ,  A61K51/00 ,  C07B59/00 ,  G01T1/161 ,  C07C309/73 ,  G21H5/02

CPC分类号： G21H5/02 ,  A61K51/0406 ,  C07B59/001 ,  C07B2200/09 ,  C07C303/28 ,  C07C303/44 ,  C07C2601/04 ,  Y02P20/55 ,  C07C309/73 ,  C07C309/65 ,  C07C309/66

摘要： A process for producing a labeled precursor which is useful for production of a radioactive fluorine-labeled amino acid compound is provided. In the reaction step for introducing a leaving group to a mixture of syn-form and anti-form of FACBC, a base is allowed to present in the reaction system to produce a syn-leaving group adduct which is unreactive with the base and is highly stable and an anti-leaving group adduct which can react with the base to form a water-soluble compound. By employing a purification method utilizing such a difference in solubility, the syn-leaving group adduct can be separated selectively. The base may be a linear-chain or branched-chain primary to tertiary alkylamine having 1 to 10 carbon atoms, a nitrogen-containing heterocyclic compound with 2 to 20 carbon atoms, and a nitrogen-containing hetero aromatic compound with 2 to 20 carbon atoms.

公开(公告)号：EP3055281A4

公开(公告)日：2017-09-20

申请号：EP14852607

申请日：2014-10-11

申请人： THERACOS SUB LLC

发明人： ROBERGE JACQUES ,  VAXELAIRE CARINE ,  LIU BAOHU ,  XU GE ,  ZHANG JIAN ,  TANG XINXING ,  XU BAIHUA

IPC分类号： C07C37/055 ,  C07C39/367 ,  C07C41/16 ,  C07C41/26 ,  C07C41/40 ,  C07C43/196 ,  C07C43/225 ,  C07C303/28 ,  C07C309/73

CPC分类号： C07C309/73 ,  C07B2200/05 ,  C07B2200/13 ,  C07C37/055 ,  C07C37/50 ,  C07C41/09 ,  C07C41/16 ,  C07C41/24 ,  C07C41/26 ,  C07C41/40 ,  C07C303/28 ,  C07C309/75 ,  C07C2601/02 ,  C07C39/367 ,  C07C43/225 ,  C07C43/196

摘要： Methods for preparing intermediates of SGLT2 inhibitors are provided, including crystalline forms and methods of crystallizing intermediates.

摘要翻译： 提供了制备SGLT2抑制剂中间体的方法，包括晶体形式和结晶中间体的方法。

公开(公告)号：EP1786764B1

公开(公告)日：2017-03-15

申请号：EP05771594.8

申请日：2005-08-15

申请人： Scinopharm Singapore Pte Ltd.

发明人： XIE, Meihua

IPC分类号： C07C303/40 ,  C07C309/04 ,  C07C309/29 ,  C07C311/37 ,  C07C303/28

CPC分类号： C07C303/28 ,  C07C303/40 ,  C07C311/37 ,  C07C309/66

公开(公告)号：EP1925611B1

公开(公告)日：2016-04-13

申请号：EP06810224.3

申请日：2006-09-15

申请人： Daiichi Sankyo Company, Limited

发明人： SATO, Koji ,  KAWANAMI, Kotaro ,  YAGI, Tsutomu

IPC分类号： C07C269/04 ,  C07C247/14 ,  C07C271/24 ,  C07C303/28 ,  C07C309/66 ,  C07D303/38 ,  C07B53/00

CPC分类号： C07C303/28 ,  C07B53/00 ,  C07C247/14 ,  C07C271/24 ,  C07C2601/14 ,  C07D303/38 ,  C07C309/66

公开(公告)号：EP2543662A4

公开(公告)日：2013-08-21

申请号：EP11750672

申请日：2011-03-02

申请人： SUMITOMO CHEMICAL CO

发明人： MARUNO SHINOBU ,  NAKAZAWA KOICHI

IPC分类号： C07C303/28 ,  C07C303/44 ,  C07C309/66

CPC分类号： C07C303/28 ,  C07C303/44 ,  C07C309/66