-
公开(公告)号：EP2624837A2
公开(公告)日：2013-08-14
申请号：EP11831427.7
申请日：2011-10-04
发明人： XU, Xiaodong , CUCONATI, Andrea , BLOCK, Timothy, M. , XIAO, Tong
IPC分类号： A61K31/519 , A01N43/90
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical compositions of the invention comprise triazolopyrimidines useful for the treatment of hepatitis virus in a patient.
-
2.发明公开SULFAMOYLBENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION 审中-公开作为抗病毒药物抗乙型肝炎感染的磺胺苯甲酰胺衍生物
公开(公告)号：EP2726459A1
公开(公告)日：2014-05-07
申请号：EP12807810.2
申请日：2012-06-29
申请人： Institute for Hepatitis and Virus Research , Philadelphia Health and Education Corporation d/b/a Drexel University College of Medicine
发明人： GUO, Ju-Tao , XU, Xiaodong , BLOCK, Timothy, M.
IPC分类号： C07D211/06
CPC分类号： C07C311/46 , A61K31/167 , A61K31/18 , A61K31/341 , A61K31/44 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/553 , A61K2300/00 , C07D211/96 , C07D213/40 , C07D223/04 , C07D281/16 , C07D295/26 , C07D307/52 , C07D307/68
摘要： Pharmaceutical compositions of the invention comprise sulfamoylbenzamide derivative useful as pregenomic RNA encapsidation inhibitors, useful for the treatment of Hepatitis B virus (HBV) infection.
摘要翻译： 本发明的药物组合物包含用作前基因组RNA包衣抑制剂的氨磺酰基苯甲酰胺衍生物，其可用于治疗乙型肝炎病毒（HBV）感染。
-
公开(公告)号：EP2462240A1
公开(公告)日：2012-06-13
申请号：EP10807057.4
申请日：2010-08-03
IPC分类号： C12Q1/00 , G01N33/569 , C07K1/00
CPC分类号： G01N33/57438 , G01N33/6893 , G01N2333/4724 , G01N2440/38 , G01N2800/085 , G01N2800/50
摘要： The present invention provides methods, compositions, apparatus, and kits for assessing glycoforms of proteins as a biomarker for disease. A purified recombinant form of lectin is used as a detector molecule to specifically label target sugars expressed in disease states. The high affinity of recombinant lectin allows for automation of assays that would be used in the diagnosis of diseases such as, but not limited to, cancer or liver disease.
-
4.发明授权
公开(公告)号：EP2462240B1
公开(公告)日：2017-07-05
申请号：EP10807057.4
申请日：2010-08-03
IPC分类号： C07K14/47 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57438 , G01N33/6893 , G01N2333/4724 , G01N2440/38 , G01N2800/085 , G01N2800/50
-
5.发明公开2-AMINO-2,7-DIDEOXY-ALPHA-D-GLYCERO-D-GLUCO-HEPTOPYRANOSYL INHIBITORS OF POSITIVE SENSE SINGLE-STRANDED RNA ENVELOPE VIRUSES 审中-公开的正单链RNA的2-氨基-2,7-二脱氧基-α-D-甘油-D-葡糖-HEPTOPYRANOSYL抑制剂包膜病毒
公开(公告)号：EP2197451A1
公开(公告)日：2010-06-23
申请号：EP08770322.9
申请日：2008-06-06
IPC分类号： A61K31/70
CPC分类号： C07D309/14 , C07H15/23
摘要： The present invention is directed to compounds, compositions and methods comprising the aminoglycoside moiety represented by Formula (II) for treating and preventing the spread of positive sense single-stranded RNA envelope viral infections. One embodiment of the present invention uses geneticin or its analogs, including 2-amino-2,7-dideoxy-alpha-D-glycero-D-gluco-heptopyranose, as the antiviral agent. The compounds, compositions and methods of the present invention are applicable to infections resulting from Hepatitis C virus, West Nile virus, Yellow Fever virus, Dengue virus, Bovine Viral Diarrhea virus, Equine Arteritis virus, and/or Sindbis virus.
-
6.发明公开SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION 审中-公开取代的氨基噻唑癌细胞的酶抑制剂，包括原发性肝癌和肝炎病毒复制抑制剂
公开(公告)号：EP2763674A1
公开(公告)日：2014-08-13
申请号：EP12838333.8
申请日：2012-10-04
IPC分类号： A61K31/425 , A61K31/426 , C07D417/00 , C07D417/02
CPC分类号： C07D417/14 , A61K31/425 , A61K31/426 , C07D277/42 , C07D417/04 , C07D417/12 , C07D487/04 , C07D495/04 , Y02A50/463
摘要： Pharmaceutical compositions of the invention comprise substituted aminothiazoles derivatives having a disease-modifying action in the treatment of diseases associated with unregulated cell growth that include hepatocellular carcinoma, and infection with a hepatitis virus.
摘要翻译： 本发明的药物组合物包含substituiertem氨基噻唑确实具有在与细胞生长失调有关的疾病的治疗疾病缓解动作衍生物包括肝细胞癌，和感染肝炎病毒。
-
7.发明公开INHIBITORS OF SECRETION OF HEPATITIS B VIRUS ANTIGENS FOR TREATMENT OF A CHRONIC HEPATITIS VIRUS 审中-公开分泌乙型肝炎病毒抗原的慢性乙型肝炎治疗病毒抑制剂
公开(公告)号：EP2019830A2
公开(公告)日：2009-02-04
申请号：EP07761888.2
申请日：2007-05-04
IPC分类号： C07D487/04 , A61K31/519 , A61K31/662 , C07F9/32 , A61P31/22
CPC分类号： A61K31/519 , A61K31/7052 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition comprising an effective amount of a compound of formulas (I-III) and a pharmaceutically acceptable carrier. Methods for treating a hepatitis virus in a patient comprising administering an effective amount of the compound of formulas (I-III) are also presented.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.01 秒)
