-
1.发明公开INHIBITORS OF SECRETION OF HEPATITIS B VIRUS ANTIGENS FOR TREATMENT OF A CHRONIC HEPATITIS VIRUS 审中-公开分泌乙型肝炎病毒抗原的慢性乙型肝炎治疗病毒抑制剂
公开(公告)号：EP2019830A2
公开(公告)日：2009-02-04
申请号：EP07761888.2
申请日：2007-05-04
IPC分类号： C07D487/04 , A61K31/519 , A61K31/662 , C07F9/32 , A61P31/22
CPC分类号： A61K31/519 , A61K31/7052 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition comprising an effective amount of a compound of formulas (I-III) and a pharmaceutically acceptable carrier. Methods for treating a hepatitis virus in a patient comprising administering an effective amount of the compound of formulas (I-III) are also presented.
-
公开(公告)号：EP2624837A2
公开(公告)日：2013-08-14
申请号：EP11831427.7
申请日：2011-10-04
发明人： XU, Xiaodong , CUCONATI, Andrea , BLOCK, Timothy, M. , XIAO, Tong
IPC分类号： A61K31/519 , A01N43/90
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical compositions of the invention comprise triazolopyrimidines useful for the treatment of hepatitis virus in a patient.
-
3.发明公开SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION 审中-公开取代的氨基噻唑癌细胞的酶抑制剂，包括原发性肝癌和肝炎病毒复制抑制剂
公开(公告)号：EP2763674A1
公开(公告)日：2014-08-13
申请号：EP12838333.8
申请日：2012-10-04
IPC分类号： A61K31/425 , A61K31/426 , C07D417/00 , C07D417/02
CPC分类号： C07D417/14 , A61K31/425 , A61K31/426 , C07D277/42 , C07D417/04 , C07D417/12 , C07D487/04 , C07D495/04 , Y02A50/463
摘要： Pharmaceutical compositions of the invention comprise substituted aminothiazoles derivatives having a disease-modifying action in the treatment of diseases associated with unregulated cell growth that include hepatocellular carcinoma, and infection with a hepatitis virus.
摘要翻译： 本发明的药物组合物包含substituiertem氨基噻唑确实具有在与细胞生长失调有关的疾病的治疗疾病缓解动作衍生物包括肝细胞癌，和感染肝炎病毒。
-
4.发明公开TAGGED HEPADNAVIRUS E ANTIGEN AND ITS USE IN SCREENING ANTIVIRAL SUBSTANCES 审中-公开标记的HEPADNAVIRUS E抗原及其在筛选抗病毒物质中的应用
公开(公告)号：EP3157944A1
公开(公告)日：2017-04-26
申请号：EP15733379.0
申请日：2015-06-19
发明人： GUO, Haitao , CAI, Dawei , CUCONATI, Andrea , JI, Changhua
IPC分类号： C07K14/005 , G01N33/576
CPC分类号： C07K14/005 , C07K2319/40 , C07K2319/42 , C12N2730/10122 , C12N2730/10151 , C12N2830/006 , G01N33/502 , G01N2333/02
摘要： The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.
摘要翻译： 本发明涉及用于筛选抗肝炎病毒物质的方法和用途，其中所述物质筛选抑制肝炎病毒如乙型肝炎病毒的共价闭合环状（ccc）DNA的能力。 该方法和用途利用了包含编码标记的肝炎病毒e抗原的核酸序列如乙型肝炎病毒e抗原（HBeAg）的细胞。 此外，本发明提供了编码标记的肝炎病毒e抗原和由其编码的蛋白质的核酸序列。 还提供了用于筛选方法的试剂盒。
-
5.发明公开BINHIBITORS OF HEPATITIS B VIRUS CONVALENTLY CLOSED CIRCULAR DNA FORMATION AND THEIR METHOD OF USE 审中-公开乙型肝炎病毒具有共价闭合环状DNA SHAPING抑制剂和它们的使用方法
公开(公告)号：EP2819671A2
公开(公告)日：2015-01-07
申请号：EP13755289.9
申请日：2013-02-28
申请人： Baruch S. Blumberg Institute , Philadelphia Health and Education Corporation d/b/a Drexel University College of Medicine
发明人： CUCONATI, Andrea , GUO, Haitao , BLOCK, Timothy M. , GUO, Ju-Tao , XU, Xiaodong , LU, Huagang , CAI, Dawei
IPC分类号： A61K31/4745
CPC分类号： C07D471/04 , A61K31/4409 , A61K31/445 , A61K31/4465 , A61K31/505 , C07C311/21 , C07C317/32 , C07D209/08 , C07D211/26 , C07D211/34 , C07D211/60 , C07D213/40 , C07D213/56 , C07D213/76 , C07D235/08 , C07D239/26 , C07D263/56 , C07D277/64 , C07D295/135 , C07D295/155 , C07D401/12
摘要： Pharmaceutical compositions of the invention comprise covalently closed circular DNA formation inhibitors having a disease-modifying action in the treatment of diseases associated with the formation of covalently closed circular DNA that include hepatitis B infection, and any disease involving formation of covalently closed circular DNA.
摘要翻译： 本发明的药物组合物包含共价闭合环状DNA形成抑制剂具有在具有共价闭合环状DNA的形成相关的疾病的治疗疾病缓解动作确实包括乙型肝炎病毒感染，和任何疾病涉及形成共价闭合环状DNA的。
-
公开(公告)号：EP3157944B1
公开(公告)日：2019-10-09
申请号：EP15733379.0
申请日：2015-06-19
发明人： GUO, Haitao , CAI, Dawei , CUCONATI, Andrea , JI, Changhua
IPC分类号： C07K14/005 , G01N33/576
-
公开(公告)号：EP3521303A1
公开(公告)日：2019-08-07
申请号：EP19158753.4
申请日：2015-06-19
发明人： GUO, Haitao , CAI, Dawei , CUCONATI, Andrea , JI, Changhua
IPC分类号： C07K14/005 , G01N33/576
摘要： The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.017 秒)
