公开(公告)号：EP3597653A1

公开(公告)日：2020-01-22

申请号：EP18184450.7

申请日：2018-07-19

申请人： IRBM S.P.A. ,  Promidis S.r.l. ,  Ospedale San Raffaele S.r.l. ,  Istituto Nazionale Di Genetica Molecolare-INGM

发明人： De Francesco, Raffaele ,  Donnici, Lorena ,  Guidotti, Luca ,  Iannacone, Matteo ,  Di Fabio, Romano ,  Summa, Vincenzo ,  Bencheva, Leda Ivanova ,  De Matteo, Marilenia ,  Ferrante, Luca ,  Prandi, Adolfo ,  Randazzo, Pietro

IPC分类号： C07D513/04 ,  A61K31/407 ,  C07D513/20 ,  C07D515/04 ,  C07D515/20 ,  C07D285/28 ,  C07D291/08 ,  A61P31/20

摘要： The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.

公开(公告)号：EP2653554A1

公开(公告)日：2013-10-23

申请号：EP12164436.3

申请日：2012-04-17

申请人： Istituto Nazionale Di Genetica Molecolare-INGM

发明人： Abrignani, Sergio ,  De Candia, Paola

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The present invention relates to a biomarker of immunity response for use in monitoring the acquired immunity of an immunized subject, to an in vitro method and a kit for monitoring the acquired immunity of an immunized subj ect.

摘要翻译： 本发明涉及用于监测免疫受试者的获得性免疫的免疫应答生物标志物，体外方法和用于监测免疫接种的获得性免疫的试剂盒。

公开(公告)号：EP2475785A2

公开(公告)日：2012-07-18

申请号：EP10771185.5

申请日：2010-09-06

申请人： Istituto Nazionale Di Genetica Molecolare-INGM

发明人： PAGANI, Massimiliano ,  DE FRANCESCO, Raffaele ,  ABRIGNANI, Sergio ,  ROSSETTI, Grazisa ,  ROSSI, Riccardo Lorenzo

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178

摘要： A method for diagnosing or prognosticating hepatocellular carcinoma, also in the early stages, or for assessing the risk of developing hepatocellular carcinoma, or for monitoring the effectiveness of an anti-tumour therapy against hepatocellular carcinoma by measuring the expression level of at least one miRNA gene product in a peripheral blood sample or in a biological fluid sample. Said method comprises measuring, in an isolated sample of peripheral blood or biological fluid, the expression level of at least one miRNA gene product, and comparing said measured expression level with a reference level. Such method can also be used to diagnose or assess the risk of developing liver cirrhosis in patients affected by chronic hepatitis, or to prognosticate the evolution of cirrhosis in patients affected by cirrhosis, or to monitor the effectiveness of a pharmacological therapy against liver cirrhosis.

公开(公告)号：EP3985010A1

公开(公告)日：2022-04-20

申请号：EP20201798.4

申请日：2020-10-14

申请人： Promidis S.r.l. ,  Ospedale San Raffaele S.r.l. ,  Istituto Nazionale Di Genetica Molecolare-INGM ,  IRBM S.P.A.

发明人： Di Fabio, Romano ,  Summa, Vincenzo ,  Bencheva, Leda Ivanova ,  Prandi, Adolfo ,  De Matteo, Marilenia ,  Randazzo, Pietro ,  De Francesco, Raffaele ,  Donnici, Lorena ,  Guidotti, Luca ,  Iannacone, Matteo

IPC分类号： C07D515/20 ,  A61K31/554 ,  A61P31/20

摘要： The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.

公开(公告)号：EP3940075A1

公开(公告)日：2022-01-19

申请号：EP20186492.3

申请日：2020-07-17

申请人： Istituto Nazionale Di Genetica Molecolare-INGM

发明人： Bodega, Beatrice ,  Marasca, Federica

IPC分类号： C12N15/113 ,  A61K31/7088 ,  A61P35/00

摘要： The present invention relates to a suppressor or inhibitor of (long interspersed element 1) LINE1 (L1) expression for medical use.

公开(公告)号：EP3833672A1

公开(公告)日：2021-06-16

申请号：EP19749375.2

申请日：2019-08-09

申请人： Ospedale San Raffaele S.r.l. ,  IRBM S.P.A. ,  Promidis S.r.l. ,  Istituto Nazionale Di Genetica Molecolare-INGM

发明人： DE FRANCESCO, Raffaele ,  DONNICI, Lorena ,  GUIDOTTI, Luca ,  IANNACONE, Matteo ,  DI FABIO, Romano ,  SUMMA, Vincenzo ,  PRANDI, Adolfo ,  RANDAZZO, Pietro ,  GORNATI, Davide ,  GRILLO, Alessandro ,  FERRANTE, Luca ,  BENCHEVA, Leda Ivanova ,  DE MATTEO, Marilenia ,  FERRARA, Marco

IPC分类号： C07D513/14 ,  C07D515/04 ,  C07D515/14 ,  C07D515/18 ,  C07D519/00 ,  A61K31/554 ,  A61P31/20

公开(公告)号：EP3640330A1

公开(公告)日：2020-04-22

申请号：EP18200482.0

申请日：2018-10-15

申请人： Consiglio Nazionale Delle Ricerche ,  Istituto Nazionale Di Genetica Molecolare-INGM ,  IFOM Fondazione Istituto Firc di Oncologia Molecolare

发明人： LANZUOLO, Chiara ,  MARULLO, Fabrizia ,  LUCINI, Federica ,  FERRARI, Francesco ,  SEBESTYÉN, Endre

IPC分类号： C12N15/10

摘要： The present invention relates to an in vitro method for analyzing chromosomal nucleic acids, the method comprising:
a) providing at least one isolated cell that comprises genetic material and
b) performing a salt-based sequential fractionation of genetic material to separate genomic regions on the basis of their accessibility and obtain chromatin fractions and
c) extracting the nucleic acids from the above chromatin fractions and
d) optionally sonicating the extracted nucleic acids such that chromatin is fragmented to have comparable profile of different fractions and
e) sequencing the extracted nucleic acids of step c) or the sonicated nucleic acid of step d).

公开(公告)号：EP2257621A1

公开(公告)日：2010-12-08

申请号：EP09725161.5

申请日：2009-03-26

申请人： Istituto Nazionale Di Genetica Molecolare-INGM

发明人： ABRIGNANI, Sergio ,  CROSTI, Mariacristina ,  MORO, Monica

IPC分类号： C12N5/06 ,  C07K14/705

CPC分类号： C07K14/705 ,  A61K35/26 ,  A61K35/28 ,  A61K38/2013 ,  C12N5/0635 ,  G01N33/5047 ,  G01N33/564 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/24 ,  A61K2300/00

摘要： The present invention relates to ex vivo hematopoietic cells characterized by the expression of the protein KRTCAP3 on the surface of said cells, to methods for isolating said cells and to ligands for KRTCAP3.

公开(公告)号：EP3741762A1

公开(公告)日：2020-11-25

申请号：EP19176238.4

申请日：2019-05-23

申请人： IRBM S.P.A. ,  Promidis S.r.l. ,  Ospedale San Raffaele S.r.l. ,  Istituto Nazionale Di Genetica Molecolare-INGM

发明人： De Francesco, Raffaele ,  Donnici, Lorena ,  Di Fabio, Romano ,  Summa, Vincenzo ,  Guidotti, Luca ,  Iannacone, Matteo ,  Bencheva, Leda Ivanova ,  De Matteo, Marilenia ,  Ferrante, Luca ,  Prandi, Adolfo ,  Randazzo, Pietro ,  Gornati, Davide ,  Grillo, Alessandro

IPC分类号： C07D513/14 ,  C07D515/14 ,  A61P31/20 ,  A61K31/407

摘要： The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.

公开(公告)号：EP3608326A1

公开(公告)日：2020-02-12

申请号：EP18188409.9

申请日：2018-08-10

申请人： IRBM S.P.A. ,  Promidis S.r.l. ,  Ospedale San Raffaele S.r.l. ,  Istituto Nazionale Di Genetica Molecolare-INGM

发明人： De Francesco, Raffaele ,  De Matteo, Marilenia ,  Prandi, Adolfo ,  Randazzo, Pietro ,  Donnici, Lorena ,  Guidotti, Luca ,  Iannacone, Matteo ,  Di Fabio, Romano ,  Summa, Vincenzo ,  Bencheva, Leda Ivanova ,  Ferrara, Marco

IPC分类号： C07D513/14 ,  C07D515/04 ,  C07D515/14 ,  C07D515/18 ,  C07D519/00 ,  A61K31/554 ,  A61P31/20

摘要： The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.