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1.发明授权A METHOD FOR DETECTING IGF1R ABERRATIONS IN CIRCULATING TUMOR CELLS USING FISH 有权一种利用鱼类检测循环肿瘤细胞中IGF1R区域的方法
公开(公告)号：EP2279266B1
公开(公告)日：2017-10-11
申请号：EP09725711.7
申请日：2009-03-25
IPC分类号： C12Q1/68
CPC分类号： G01N33/57492 , C12Q1/6841 , C12Q1/6886 , C12Q2600/156 , G01N2333/71
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2.发明授权METHODS AND KITS FOR THE DETECTION OF CIRCULATING TUMOR CELLS IN PANCREATIC PATIENTS USING POLYSPECIFIC CAPTURE AND COCKTAIL DETECTION REAGENTS 有权方法和药盒中循环胰腺肿瘤患者的肿瘤细胞多特异性捕捉和鸡尾酒检测试剂的检测
公开(公告)号：EP2628008B1
公开(公告)日：2017-05-31
申请号：EP11778732.5
申请日：2011-10-13
IPC分类号： G01N33/543 , G01N33/574
CPC分类号： G01N33/57492 , G01N33/54333
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公开(公告)号：EP2584050B1
公开(公告)日：2017-05-31
申请号：EP13151356.6
申请日：2008-11-13
发明人： Palma, John F. , Backus, John W. , Zhang, Yi , Wang, Yixin , Yu, Jack X. , Vener, Tatiana , Derecho, Carlo , Lee, DongHo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G06F19/20 , G06F19/24 , G16H50/20 , Y02A90/26
摘要： Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes, 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described kits for the rapid diagnosis of diabetic disease states in patients at a 5 point of care facility.
摘要翻译： 公开了用于鉴定在诊断患有糖尿病前期疾病状态和明显II型糖尿病的患者的PBMC中差异表达的基因集的方法，显示3个基因和10个基因标记准确预测患者的糖尿病疾病状态。 该应用还描述了用于在5点护理机构中对患者中的糖尿病疾病状态进行快速诊断的试剂盒。
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公开(公告)号：EP2272989B1
公开(公告)日：2017-01-04
申请号：EP10251223.3
申请日：2010-07-08
发明人： Talantov, Dmitri , Palma, John F. , Jatkoe, Tim , Vener, Tatiana , Wang, Yixin , Wang, Haiying
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
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5.发明授权A METHOD FOR PREDICTING PROGRESSION FREE AND OVERALL SURVIVAL AT EACH FOLLOW-UP TIME POINT DURING THERAPY OF METASTATIC BREAST CANCER PATIENTS USING CIRCULATING TUMOR CELLS 有权为生存总共没有疾病FORT VIOLATION预测方法对每个后续的乳腺癌患者的治疗时间使用转移性循环肿瘤细胞
公开(公告)号：EP1861509B1
公开(公告)日：2015-09-09
申请号：EP05725638.0
申请日：2005-03-14
发明人： ALLARD, Jeffrey, W. , DOYLE, Gerald, V. , HAYES, Daniel, F. Comprehensive Cancer Center , MILLER, Michael, Craig , TERSTAPPEN, Leon, W., M., M.
IPC分类号： C12Q1/00 , G01N33/48 , G01N33/53 , G01N33/574
CPC分类号： G01N33/574
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公开(公告)号：EP2024893B1
公开(公告)日：2015-03-04
申请号：EP07794520.2
申请日：2007-05-03
发明人： GREVE, Jan , SCHREUDER, Frederik
IPC分类号： G06F19/00 , G06T7/40 , G01N33/543
CPC分类号： G01N33/54326 , Y10T436/143333
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公开(公告)号：EP1888785B1
公开(公告)日：2015-03-04
申请号：EP06770766.1
申请日：2006-05-18
发明人： JIANG, Yuqiu , BACKUS, John W. , MAZUMDER, Abhijit , CHOWDARY, Dondapati , YANG, Fei , WANG, Yixin , JATKOE, Timothy
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154
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8.发明授权AUTOMATED ENUMERATION AND CHARACTERIZATION OF CIRCULATING MELANOMA CELLS IN BLOOD 有权自动计数和表征血液中循环黑素瘤细胞
公开(公告)号：EP2225563B1
公开(公告)日：2015-01-21
申请号：EP08855440.7
申请日：2008-10-20
IPC分类号： G01N33/574
CPC分类号： G01N33/5743 , G01N33/57488 , G01N2333/70589 , G01N2333/70596
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公开(公告)号：EP2215266B1
公开(公告)日：2015-01-14
申请号：EP08849756.5
申请日：2008-11-13
发明人： PALMA, John, F. , BACKUS, John, W. , ZHANG, Yi , WANG, Yixin , YU, Jack, X. , VENER, Tatiana , DERECHO, Carlo , LEE, Dong-Ho
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G06F19/20 , G06F19/24 , G16H50/20 , Y02A90/26
摘要： Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes, 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described kits for the rapid diagnosis of diabetic disease states in patients at a 5 point of care facility.
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公开(公告)号：EP2739138A1
公开(公告)日：2014-06-11
申请号：EP12822609.9
申请日：2012-08-03
发明人： LI, Zhiyu , RUSSELL, Thomas , GAO, Jun
CPC分类号： C07K1/1077 , B01J20/28009 , B01J20/286 , B01J20/3204 , B01J20/3217 , B01J20/3229 , B01J20/3274 , B01J20/3282 , B01J39/26 , B01J41/20 , C07K1/22 , C07K17/14 , G01N33/532
摘要： Functionalized magnetic particles are emerging as a reliable and convenient technique in the purification of biomacromolecules (proteins and nucleic acids). We disclose a novel coupling procedure that can be used to create stable ferromagnetic nickel particles coated with Protein A for the affinity purification of antibody. The protein purification procedure is gentle, scalable, automatable, efficient and economical. By modifying the functional groups of amino acids in the protein coating, nickel particles can be used not only for affinity purification but for other sample preparation and chromatographic applications as well including nucleic acid isolations. The method can be easily modified for small and medium scale antibody purification in lab and pre-clinical research.
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