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公开(公告)号：EP2833930A4
公开(公告)日：2015-07-08
申请号：EP13771865
申请日：2013-03-15
申请人： UNIV WASHINGTON CT COMMERCIALI , KIM DEOK-HO , LAFLAMME MICHAEL , MURRY CHARLES , GUPTA KSHITIZ , YOO HYOK , JIAO ALEX
发明人： KIM DEOK-HO , LAFLAMME MICHAEL , MURRY CHARLES , GUPTA KSHITIZ , YOO HYOK , JIAO ALEX
CPC分类号： C12N5/0606 , A61K48/00 , A61L27/14 , A61L27/18 , A61L27/3826 , A61L27/3834 , A61L27/3873 , A61L27/50 , A61L2400/12 , A61L2400/18 , B01L3/5085 , B01L2300/0851 , B01L2300/0896 , B01L2400/086 , C12M21/08 , C12M25/14 , C12N5/0657 , C12N5/0658 , C12N5/0696 , C12N2503/02 , C12N2533/30 , C12N2533/40 , C12N2535/00 , C08L67/04
摘要： The present invention generally relates to the field of cell growth and tissue engineering, in particular, tissue engineered compositions comprising a nanotextured substrate which is structurally configured for growth of cells in an anatomically correct adult phenotype in vitro. In particular, described herein are nanotextured substrates which are structurally configured for the anisotropic organization, maturation, and growth of in vitro-differentiated muscle cells, such as cardiomyocytes, and methods for the production and use thereof in varying sizes, nanotextures and substrate rigidities. In vitro-differentiated cardiomyocytes grown on the nanotextured substrates described herein are better-differentiated and more closely mimic adult cardiac tissue than the same cells grown on a non-textured substrate of the same composition. The nanotextured substrate/cell constructs provide a platform for screening to predict the effect of test agents or drugs on, for example, human cardiac tissue, including patient-derived tissue, or for the identification of agents that effect various cardiac functional parameters.
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公开(公告)号：EP2833930A1
公开(公告)日：2015-02-11
申请号：EP13771865.6
申请日：2013-03-15
申请人： University Of Washington Through Its Center For Commercialization , Kim, Deok-Ho , Laflamme, Michael , Murry, Charles , Gupta, Kshitiz , Yoo, Hyok , Jiao, Alex
发明人： KIM, Deok-Ho , LAFLAMME, Michael , MURRY, Charles , GUPTA, Kshitiz , YOO, Hyok , JIAO, Alex
CPC分类号： C12N5/0606 , A61K48/00 , A61L27/14 , A61L27/18 , A61L27/3826 , A61L27/3834 , A61L27/3873 , A61L27/50 , A61L2400/12 , A61L2400/18 , B01L3/5085 , B01L2300/0851 , B01L2300/0896 , B01L2400/086 , C12M21/08 , C12M25/14 , C12N5/0657 , C12N5/0658 , C12N5/0696 , C12N2503/02 , C12N2533/30 , C12N2533/40 , C12N2535/00 , C08L67/04
摘要： The present invention generally relates to the field of cell growth and tissue engineering, in particular, tissue engineered compositions comprising a nanotextured substrate which is structurally configured for growth of cells in an anatomically correct adult phenotype in vitro. In particular, described herein are nanotextured substrates which are structurally configured for the anisotropic organization, maturation, and growth of in vitro-differentiated muscle cells, such as cardiomyocytes, and methods for the production and use thereof in varying sizes, nanotextures and substrate rigidities. In vitro-differentiated cardiomyocytes grown on the nanotextured substrates described herein are better-differentiated and more closely mimic adult cardiac tissue than the same cells grown on a non-textured substrate of the same composition. The nanotextured substrate/cell constructs provide a platform for screening to predict the effect of test agents or drugs on, for example, human cardiac tissue, including patient-derived tissue, or for the identification of agents that effect various cardiac functional parameters.
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公开(公告)号：EP2833930B1
公开(公告)日：2018-05-30
申请号：EP13771865.6
申请日：2013-03-15
申请人： University of Washington through its Center for Commercialization , Kim, Deok-Ho , Laflamme, Michael , Murry, Charles , Gupta, Kshitiz , Yoo, Hyok , Jiao, Alex
发明人： KIM, Deok-Ho , LAFLAMME, Michael , MURRY, Charles , GUPTA, Kshitiz , YOO, Hyok , JIAO, Alex
CPC分类号： C12N5/0606 , A61K48/00 , A61L27/14 , A61L27/18 , A61L27/3826 , A61L27/3834 , A61L27/3873 , A61L27/50 , A61L2400/12 , A61L2400/18 , B01L3/5085 , B01L2300/0851 , B01L2300/0896 , B01L2400/086 , C12M21/08 , C12M25/14 , C12N5/0657 , C12N5/0658 , C12N5/0696 , C12N2503/02 , C12N2533/30 , C12N2533/40 , C12N2535/00 , C08L67/04
摘要： The present invention generally relates to the field of cell growth and tissue engineering, in particular, tissue engineered compositions comprising a nanotextured substrate which is structurally configured for growth of cells in an anatomically correct adult phenotype in vitro. In particular, described herein are nanotextured substrates which are structurally configured for the anisotropic organization, maturation, and growth of in vitro-differentiated muscle cells, such as cardiomyocytes, and methods for the production and use thereof in varying sizes, nanotextures and substrate rigidities. In vitro-differentiated cardiomyocytes grown on the nanotextured substrates described herein are better-differentiated and more closely mimic adult cardiac tissue than the same cells grown on a non-textured substrate of the same composition. The nanotextured substrate/cell constructs provide a platform for screening to predict the effect of test agents or drugs on, for example, human cardiac tissue, including patient-derived tissue, or for the identification of agents that effect various cardiac functional parameters.
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