公开(公告)号：EP2560000B1

公开(公告)日：2018-12-26

申请号：EP11769117.0

申请日：2011-04-15

申请人： Cytogen Co., Ltd.

发明人： JEON, Byung Hee

IPC分类号： G01N33/487 ,  G01N35/08 ,  G01N1/28 ,  A61J1/05

CPC分类号： G01N1/34 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2300/0816 ,  B01L2400/086 ,  G01N1/4077 ,  G01N15/02 ,  G01N33/491 ,  G01N35/1095 ,  G01N2035/00158 ,  G01N2035/1053

摘要： The present invention discloses a micro-fluidic device for separating targets from a sample and a target separating method using the same. The micro-fluidic device includes a filter case, a first capture array and a second capture array. The filter case includes an inlet for introducing a sample containing different kinds of targets, an outlet for discharging the sample and a channel extending between the inlet and the outlet. The first capture array is arranged in an upstream portion of the channel, the first capture array including a plurality of first forward funnels arranged along a direction orthogonal to a flow direction of the sample so as to capture the different kinds of targets. The second capture array is arranged in a downstream portion of the channel, the second capture array including a plurality of second forward funnels arranged along the direction orthogonal to the flow direction of the sample so as to capture the different kinds of targets.

公开(公告)号：EP1893337B1

公开(公告)日：2018-11-14

申请号：EP06747937.8

申请日：2006-06-20

申请人： Crimson International Assets LLC

发明人： ÖHMAN, Per, Ove ,  MENDEL-HARTVIG, Ib

IPC分类号： B01L3/00

CPC分类号： B01L3/5025 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/086 ,  Y10T436/2575

摘要： A fluid handling device for handling a fluid to be assayed, comprises non-porous substrate having a substrate surface; fluid passage(s) having two, opposite ends; and absorbing zone(s) in fluid contact with the second end of the first passage. The absorbing zone(s) comprises projections perpendicular to the substrate surface. The projections have a height, diameter and distance(s) between the projections, and are capable of generating capillary flow, lateral to the substrate surface, of a fluid placed in contact with the absorbing zone from the second end of the fluid passage(s). An independent claim is also included for a method for handling fluid transport in fluid passage(s) (11, 13, 15) on a non-porous substrate having a substrate surface, comprising establishing and/or maintaining fluid transport in the passage by an absorbing zone (17, 19, 21), the absorbing zone(s) comprising projections perpendicular to the substrate surface. The projections have a height, diameter and distance(s) between the projections, and are capable of generating capillary flow, lateral to the substrate surface, of a fluid placed in contact with the absorbing zone from the second end of the fluid passage(s).

公开(公告)号：EP3023335B1

公开(公告)日：2018-10-31

申请号：EP15200612.8

申请日：2012-04-02

申请人： Biosurfit, S.A.

发明人： ALBUQUERQUE, Carlota ,  TENREIRO, Tânia ,  REIS, Nuno ,  GARCIA DA FONSECA, João ,  MARQUES CALEIRO CABEÇA, Ricardo Manuel

IPC分类号： B01L3/00 ,  G01N1/28 ,  B65B11/52 ,  B01L3/14

CPC分类号： G01N1/28 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/523 ,  B01L2200/0642 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/0806 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2400/0409 ,  B01L2400/0481 ,  B01L2400/0638 ,  B01L2400/0683 ,  B01L2400/086 ,  Y10T436/2575

摘要： Disclosed embodiments provide improved mechanisms for storing and introducing liquid volumes in a liquid handling device and, in particular, improved mechanisms for rupturing a liquid store to introduce liquid into the device, improvements to the stability of a liquid receiving chamber inside the device and improvements to liquid handling in the receiving chamber.

公开(公告)号：EP3383270A2

公开(公告)日：2018-10-10

申请号：EP16805425.2

申请日：2016-12-02

申请人： University Of Ulster

发明人： GIBSON, David ,  MCLAUGHLIN, James ,  MAGEE, Justin

IPC分类号： A61B5/157 ,  B01L3/00 ,  G01N1/02 ,  G01P13/00

CPC分类号： B01L3/5027 ,  A61B5/150022 ,  A61B5/150343 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/15087 ,  A61B5/15142 ,  A61B5/157 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/023 ,  B01L2300/0645 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/086

摘要： This invention relates to a liquid sample collection apparatus comprising, a port 11 for receiving a liquid sample, a collector 19 for storing said liquid sample, at least one conduit 15 connecting said port to said collector, and a sample detection apparatus 25 comprising a sensor 24 for detecting said liquid in said collector and generating an output depending on the quantity of said liquid detected in said collector, and a controller 30 responsive to said sensor output and configured to determine that said sample has been collected when said sensor output indicates that a quantity of said liquid above a threshold amount is detected in said collector. Preferably the sensor comprises a pair of electrodes which are electrically connected when a sufficient amount of sample is present. The collector may comprise of filter paper. A piercing element (13, figure 4) may be included in some embodiments. In embodiments the liquid may be blood. In embodiments, a liquid-transportable tracer material may be included. In embodiments a filter 17 is provided in the conduit.

公开(公告)号：EP3365106A1

公开(公告)日：2018-08-29

申请号：EP16787404.9

申请日：2016-10-21

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Institut Curie ,  UNIVERSITE PIERRE ET MARIE CURIE - PARIS VI

发明人： VILLARD, Catherine ,  VIOVY, Jean-Louis ,  RENAULT, Renaud ,  DURAND, Jean-Baptiste ,  PEYRIN, Jean-Michel ,  FERRANTE, Ivan

IPC分类号： B01L3/00

CPC分类号： B01L3/502761 ,  B01L2300/0858 ,  B01L2300/088 ,  B01L2400/086 ,  C12M23/16 ,  C12M47/04

摘要： The present invention relates to a microfluidic device to manipulate, select, treat, or cultivate living bodies, comprising a first chamber, a second chamber and a network of guiding tracks, wherein: said network of guiding tracks comprises at least one first guiding track connecting the first chamber and the second chamber and at least one second guiding track connecting said at least one first guiding track with at least two interconnections; and said at least one second guiding track comprises a curved part; said curved part exhibiting a concavity facing the second chamber or the part of the network connected to the second chamber.

公开(公告)号：EP2783211B1

公开(公告)日：2018-08-15

申请号：EP12788531.7

申请日：2012-11-20

申请人： Ovizio Imaging Systems NV

发明人： MAGNIETTE, Olivier

IPC分类号： G01N33/487 ,  G01N33/574

CPC分类号： G01N33/48778 ,  A61B10/0291 ,  A61B2010/0216 ,  B01L3/502 ,  B01L3/5082 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2300/023 ,  B01L2300/042 ,  B01L2300/0609 ,  B01L2300/0681 ,  B01L2300/0803 ,  B01L2300/0832 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2400/086 ,  G01N1/405 ,  G01N21/03 ,  G01N33/57411 ,  G03H1/0443 ,  G03H2001/005

摘要： The current invention concerns a sample vial for receiving a liquid cell sample, to be used in conjunction with a digital holographic microscope (DHM), said sample vial comprises at least two compartments (1,2) in fluid connection with one another, said compartments comprising at least one pair of screening surfaces (A1,A2), said screening surfaces are essentially flat; and characterized in that the distance between the pair of screening surfaces of the second compartment is smaller than the distance between the pair of screening surfaces of the first compartment. In a second and third aspect, the current invention pertains a method and system for analyzing a liquid cell sample by DHM, employing the sample vial of the current invention.

公开(公告)号：EP3350569A1

公开(公告)日：2018-07-25

申请号：EP16847534.1

申请日：2016-09-19

申请人： Rheomics Inc.

发明人： SPERO, Richard, Chasen ,  FISHER, Jay, Kenneth ,  SUPERFINE, Richard

IPC分类号： G01N15/14 ,  G01N21/64

CPC分类号： G01N21/631 ,  B01F5/0617 ,  B01F13/0059 ,  B01F13/0091 ,  B01F2005/0636 ,  B01L3/50273 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/123 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0433 ,  B01L2400/0442 ,  B01L2400/0454 ,  B01L2400/086 ,  G01N21/05 ,  G01N33/54366

摘要： A flow cell is provided that includes surface-attached structures in a chamber. The structures are movable in response to a magnetic or electric field. A target extraction or isolation system includes the flow cell and a driver configured for applying a magnetic or electric field to the interior of the flow cell to actuate movement of the structures. The flow cell may be utilized to extract or isolate a target from a sample flowing through the flow cell. Further, a microfluidic system is provided that includes surface-attached structures and a microarray, wherein actuated motion of the surface-attached structures is used to enhance flow, circulation, and/or mixing action for analyte capture on the microarray.

公开(公告)号：EP2786019B1

公开(公告)日：2018-07-25

申请号：EP12849108.1

申请日：2012-10-17

申请人： International Business Machines Corporation ,  Coris Bioconcept SPRL

发明人： AVRAIN, Laetitia ,  DELAMARCHE, Emmanuel ,  HITZBLECK, Martina ,  LAURENT, Thierry ,  MERTENS, Pascal ,  SMEKENS, Valérie

IPC分类号： F04B53/10 ,  B81B3/00 ,  F16K7/16 ,  G01N37/00 ,  F16K99/00 ,  B01L7/00 ,  B01L3/00

CPC分类号： B01L3/00 ,  B01L3/502738 ,  B01L3/502746 ,  B01L7/52 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/14 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0688 ,  B01L2400/082 ,  B01L2400/086 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0017 ,  F16K99/0026 ,  F16K2099/008 ,  F16K2099/0084

摘要： A microfluidic device includes a first microchannel, a second microchannel, and a valve comprising at least an input port and an output port, the ports respectively connected to the first microchannel and the second microchannel, the valve designed to control a flow of a liquid along a flow direction (z) defined by the ports; wherein the valve further comprises one or more walls joining the ports and defining a hollow chamber that is wider than each of the microchannels in a direction perpendicular to the flow direction, the walls at least partly deformable along a deformation direction (−y) intersecting the flow direction, such that the walls can be given at least a first deformation state and a second deformation state, such that the liquid can be pulled along the flow direction substantially more in the second deformation state than in the first deformation state.

公开(公告)号：EP3198257A4

公开(公告)日：2018-07-18

申请号：EP15843475

申请日：2015-09-23

申请人： TEARLAB RES INC

发明人： SULLIVAN BENJAMIN ,  ZMINA STEVE ,  LEE MELISSA ,  WESTERBERG BRANDON ,  SOLOMON MATTHEW DANIEL ,  POTZNER CHRISTIAN ,  GARST SEBASTIAAN ,  SPRINGER MATTHEW ,  HAYES JASON ,  MUNSTER PETER ,  HARVEY EROL CRAIG ,  WILKINSON MICHAEL ,  SLOWINSKA JOANNA ,  LEE DEREK ,  VAN RUIJVEN PETER

IPC分类号： G01N13/04 ,  B81B1/00 ,  G01N1/10 ,  G01N33/487

CPC分类号： G01N33/487 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2200/0647 ,  B01L2200/0684 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/08 ,  B01L2300/0838 ,  B01L2300/0858 ,  B01L2300/161 ,  B01L2300/165 ,  B01L2400/0688 ,  B01L2400/086 ,  B81B1/00 ,  B81B2201/058 ,  B81B2203/0338 ,  G01N13/04 ,  G01N33/54366 ,  G01N35/10 ,  G01N2035/00237 ,  G01N2035/1034

摘要： Systems, methods, and devices for analyzing small volumes of fluidic samples, as a non-limiting example, less than twenty microliters are provided. The devices are configured to make a first sample reading, for example, measure an energy property of the fluid sample, for example, osmolality, make a second sample reading, for example, detecting the presence or concentration of one or more analytes in the fluid sample, or make both the first sample reading and the second sample reading, for example, measuring the energy property of the fluid sample as well as detecting the presence or concentration of one or more analytes in the fluid sample.

公开(公告)号：EP2010321B1

公开(公告)日：2018-07-04

申请号：EP07734907.4

申请日：2007-03-29

申请人： Alere Switzerland GmbH

发明人： LOWE, Phillip ,  KEATCH, Steven, Alexander ,  HOWELL, Steven ,  MARQUORDT, Claus ,  POLWART, Ruth ,  THOMSON, Alan, Kenneth

IPC分类号： B01L3/00 ,  G01N33/543 ,  G01N33/558 ,  G01N35/00 ,  B01L9/00

CPC分类号： G01N33/558 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/502769 ,  B01L9/527 ,  B01L2200/0621 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0683 ,  B01L2400/0688 ,  B01L2400/086 ,  G01N33/54326 ,  G01N33/54366 ,  G01N35/0098

摘要： An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid-liquid interface to the second liquid. The magnetically susceptible particles are configured to transport an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.