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    METHOD FOR MEASURING ANTI-DRUG ANTIBODY
    2.
    发明公开
    METHOD FOR MEASURING ANTI-DRUG ANTIBODY 审中-公开

    公开(公告)号：EP3239711A3

    公开(公告)日：2017-11-22

    申请号：EP17167959.0

    申请日：2017-04-25

    申请人： JIMRO Co., Ltd.

    发明人： KASHIWAGI, Nobuhito ,  SAITOH, Fumio ,  KANEDA, Kenta ,  MAEGAWA, Hidetaka ,  YAGIHASHI, Yuko

    IPC分类号： G01N33/564 ,  G01N33/68 ,  G01N33/94

    CPC分类号： G01N33/564 ,  G01N33/6854 ,  G01N33/94 ,  G01N2333/4716

    摘要： Provided is a method for measuring ADAs appearing in a patient receiving molecular-targeted therapy with a drug or the like in a simpler and more accurate manner.
    A method for measuring anti-drug antibodies (ADAs) in an analyte to be measured, the method comprising:
    (1) a step of providing a sample comprising an analyte to be measured for ADAs, the step comprising adding a corresponding drug to an analyte to be measured for ADAs to prepare a sample with a drug-ADAs immune complex formed;
    (2) a step of contacting the sample prepared in step (1) with a carrier coated with complement C1q, anti-C3d antibody, or anti-C1q antibody;
    (3) a step of contacting a labeled or non-labeled antibody to a drug corresponding to the ADAs with the coated carrier prepared in step (2); and
    (4) a step of quantifying the drug-ADAs immune complex binding to the complement C1q, anti-C3d antibody, or anti-C1q antibody.

    METHOD FOR MEASURING ANTI-DRUG ANTIBODY
    5.
    发明公开
    METHOD FOR MEASURING ANTI-DRUG ANTIBODY 审中-公开
    测量抗药物抗体的方法

    公开(公告)号：EP3239711A2

    公开(公告)日：2017-11-01

    申请号：EP17167959.0

    申请日：2017-04-25

    申请人： JIMRO Co., Ltd.

    发明人： KASHIWAGI, Nobuhito ,  SAITOH, Fumio ,  KANEDA, Kenta ,  MAEGAWA, Hidetaka ,  YAGIHASHI, Yuko

    IPC分类号： G01N33/564 ,  G01N33/68 ,  G01N33/94

    摘要： Provided is a method for measuring ADAs appearing in a patient receiving molecular-targeted therapy with a drug or the like in a simpler and more accurate manner.
    A method for measuring anti-drug antibodies (ADAs) in an analyte to be measured, the method comprising:
    (1) a step of providing a sample comprising an analyte to be measured for ADAs, the step comprising adding a corresponding drug to an analyte to be measured for ADAs to prepare a sample with a drug-ADAs immune complex formed;
    (2) a step of contacting the sample prepared in step (1) with a carrier coated with complement C1q, anti-C3d antibody, or anti-C1q antibody;
    (3) a step of contacting a labeled or non-labeled antibody to a drug corresponding to the ADAs with the coated carrier prepared in step (2); and
    (4) a step of quantifying the drug-ADAs immune complex binding to the complement C1q, anti-C3d antibody, or anti-C1q antibody.

    摘要翻译： 提供了一种用于以更简单和更准确的方式测量出现在用药物等接受分子靶向治疗的患者中出现的ADA的方法。 一种用于测量待测分析物中的抗药物抗体（ADA）的方法，所述方法包括：（1）提供包含待测ADA分析物的样品的步骤，所述步骤包括将相应的药物添加至分析物 对ADA进行测量以制备具有形成的药物-ADAs免疫复合物的样品; （2）使步骤（1）中制备的样品与包被有补体C1q，抗C3d抗体或抗C1q抗体的载体接触的步骤; （3）使标记或未标记的抗体与步骤（2）中制备的包衣载体与ADA相应的药物接触的步骤; （4）量化与补体C1q，抗C3d抗体或抗C1q抗体结合的药物-ADAs免疫复合物的步骤。

    MARROW FLUID SAMPLING SET AND MARROW NEEDLE
    6.
    发明公开
    MARROW FLUID SAMPLING SET AND MARROW NEEDLE 有权
    设置拆卸脊髓液和马克·阿德尔

    公开(公告)号：EP1421907A4

    公开(公告)日：2009-04-08

    申请号：EP02755872

    申请日：2002-08-08

    申请人： JIMRO CO LTD

    发明人： IKEHARA SUSUMU ,  NAKAMURA SHUJI ,  AOKI MASATO ,  NUMAZAWA MASAAKI ,  ADACHI MASAKAZU

    IPC分类号： A61B10/02 ,  A61B10/00 ,  A61B17/16 ,  A61B17/34 ,  A61M1/00

    CPC分类号： A61B10/025 ,  A61B10/0096 ,  A61B17/1637 ,  A61B2010/0258

    摘要： A marrow fluid sampling set and a marrow needle, the marrow fluid sampling set comprising a centrifugal separating container for sampling marrow fluid, a cap having a sampling port, and a sampling tube having a connector fitted thereto at both ends, wherein the centrifugal separating container is closed with the cap, the connector at one end of the sampling tube is fitted to the sampling port of the cap, and the connector at the other end of the sampling tube is fitted to the coat of the marrow needle retained in a marrow to sample the marrow fluid, the marrow needle comprising a tubular coat and an inner needle, wherein the inner needle is detachably inserted into the coat so that the tip of the inner needle is projected from the coat, characterized in that a drill blade is formed at the tip of the inner needle and a cutting blade is formed at the tip of the coat.

    METHOD FOR MEASURING CHOLESTEROL IN REMNANT-LIKE LIPOPROTEIN
    7.
    发明公开
    METHOD FOR MEASURING CHOLESTEROL IN REMNANT-LIKE LIPOPROTEIN 审中-公开
    维生素ZURCHOLESTERINMESSUNG在ÜBRIGBLEIBENDENLIPOPROTEINEN

    公开(公告)号：EP1975244A1

    公开(公告)日：2008-10-01

    申请号：EP07706273.5

    申请日：2007-01-19

    申请人： Jimro Co., Ltd.

    发明人： OGIHARA, Fumiko ,  NIIMI, Manabu ,  NAKANO, Takamitsu ,  KANATANI, Kazushi

    IPC分类号： C12Q1/44 ,  C12Q1/26 ,  C07K16/18

    CPC分类号： C07K16/18 ,  C12Q1/46 ,  G01N33/92 ,  G01N2333/775

    摘要： A method for measuring cholesterol in remnant-like lipoprotein in a sample, by a more convenient operation and with high sensitivity, and a reagent for the measurement are provided.
    A method for measuring cholesterol in remnant-like lipoprotein, the method comprising subjecting a test sample containing lipoproteins to the action of a cholesterol esterase and a cholesterol oxidase or cholesterol dehydrogenase, and measuring the hydrogen peroxide or reduced coenzyme generated by the enzymatic reaction, wherein a surfactant having a benzenesulfonic acid structure in the molecule or a polyacrylic acid-based polymeric surfactant is used.

    摘要翻译： 提供了通过更方便的操作和高灵敏度测量样品中残留样脂蛋白胆固醇的方法和用于测量的试剂。 一种测定残留样脂蛋白中的胆固醇的方法，其特征在于，使含有脂蛋白的试验样品对胆固醇酯酶和胆固醇氧化酶或胆固醇脱氢酶的作用进行测定，并测定通过酶反应产生的过氧化氢或还原型辅酶， 使用分子中具有苯磺酸结构的表面活性剂或聚丙烯酸类聚合物表面活性剂。