摘要:
The invention provides wound dressings comprising an absorbent (porous) hydrogel composition comprising a foam portion which comprises a flexible plasticised hydrophilic polymer matrix having an internal cellular structure, and a continuous portion which comprises a flexible plasticised hydrophilic polymer matrix having relatively continuous internal structure. The continuous portion of the hydrogel composition includes apertures providing fluid flow communication through the continuous portion between an external surface of the continuous portion and the foam portion whereby the foam portion can take up external water or other fluid into the cellular structure through the apertures of the continuous portion. The continuous portion of the hydrogel composition may be tacky to the skin, allowing its use as a bioadhesive.
摘要:
An apparatus comprising: a distributed inlet (4) for collecting and mixing wound fluids from a plurality of locations in a wound to provide a wound fluid mixture; and a sensing or indicating device (8) in fluid communication with said distributed inlet for detecting the presence of a wound fluid marker in the wound fluid mixture.
摘要:
The invention provides a wound dressing comprising a layered material comprising a hydrophilic foam layer formed from a first polyurethane and a hydrogel layer formed from a second polyurethane, wherein the hydrogel layer is laminated to the hydrophilic foam layer. The invention also provides methods for preparing the same.
摘要:
The present invention provides the use of a peptide derivative having the sequence X-NH-Gly-Pro-Ala-Gly-CO-Y, wherein X is H or a pharmaceutically acceptable N-terminal group, and Y is OH or a pharmaceutically acceptable C-terminal group, for the preparation of a medicament for use in the treatment or prevention of wound contracture.
摘要:
A wound dressing material comprising a low-moisture hydrocolloid matrix having oxidized cellulose distributed therein. For example, a matrix of dried sodium carboxymethylcelIulose gel having fibers of oxidized regenerated cellulose dispersed therein. Also provided are the use of such materials in the treatment of wounds, and the manufacture of such materials by drying aqueous gels containing dispersed particles of oxidized cellulose.
摘要:
A wound dressing comprising: a wound contacting sheet having a wound facing surface and a back surface opposite the wound facing surface, and having apertures therein that open or enlarge in the presence of wound exudate; and a plurality of particles comprising one or more therapeutic agents located behind the back surface of the back sheet, wherein the particles are able to pass through the apertures to the wound facing surface of the sheet when the apertures are opened or enlarged in the presence of said wound exudate.
摘要:
The invention provides wound dressings comprising chemically modified polysaccharides, wherein the polysaccharide has been chemically modified by the introduction of one or more thiol groups. Preferably, the modified polysaccharide is the product of a reaction between chitin/chitosan or a cellulose derivative with Lawesson’s reagent. The modified polysaccharides have antioxidant properties and selectively bind to dissolved iron, making them useful to the treatment of chronic wounds and lipodermatosclerosis.
摘要:
The invention provides wound dressings, in particular wound dressings of low- or non-exuding wounds or bleeding wounds. The wound dressings are of the island type, having an adhesive-coated backing sheet (6) and an absorbent island (9) supported on the backing sheet. The island (9) comprises a layer (2) of liquid absorbent material enclosed in an envelope of textured perforated thermoplastic film. The film (3) on one side of the island (9) presents a ribbed or embossed perforated surface having low adherency to the wound. The film (7) on the rear surface of the envelope is perforated and smoothed to provide good attachment to the backing sheet (6) and controlled water vapor transmission rate. The invention also provides a method of manufacture of the wound dressings according to the invention, according to which the absorbent layer (2) is wrapped in a textured perforated thermoplastic film, and the film on the rear face of the envelope is then preferably smoothed by blowing hot air onto it.
摘要:
The present invention provides the use of a peptide derivative having the sequence X-NH-Gly-Pro-Ala-Gly-CO-Y, wherein X is H or a pharmaceutically acceptable N-terminal group, and Y is OH or a pharmaceutically acceptable C-terminal group, for the preparation of a medicament for use in the treatment or prevention of wound contracture.
摘要:
The invention provides solid, porous, substantially insoluble composition comprising at least 25% by weight of an oxidized cellulose and having iron bonded thereto. The invention also provides a method of sequestering dissolved iron from an aqueous solution by contacting the solution with a porous, substantially insoluble solid containing at least 25% by weight of an oxidised cellulose. The selective iron-binding property of oxidized cellulose is used in the treatment of bacterial infections.