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    ADHESIVE SHEET FOR ATTACHMENT TO SKIN AND PERCUTANEOUS ABSORPTION PREPARATION USING SAME
    1.
    发明公开
    ADHESIVE SHEET FOR ATTACHMENT TO SKIN AND PERCUTANEOUS ABSORPTION PREPARATION USING SAME 审中-公开
    用于皮肤和经皮吸收制剂的粘合剂片使用相同的

    公开(公告)号：EP3228309A1

    公开(公告)日：2017-10-11

    申请号：EP15864868.3

    申请日：2015-12-04

    申请人： KM Transderm Ltd.

    发明人： OGINO, Hiroyuki ,  YUKIMOTO, Sadao ,  HAMADA, Atsuyo ,  AKAZAWA, Mitsuji ,  GOTO, Masaoki

    IPC分类号： A61K9/70 ,  A61K31/27 ,  A61K47/32

    CPC分类号： A61K9/7007 ,  A61K9/7053 ,  A61K31/27 ,  A61K47/06 ,  A61K47/32

    摘要： The present invention provides an adhesive sheet for skin, which shows sufficient adhesiveness to the skin and causes low skin irritation.
    The first adhesive sheet for skin of the present invention has an adhesive layer formed on a support, wherein the aforementioned adhesive layer contains at least a thermoplastic elastomer, non-volatile hydrocarbon oil and polyisobutylene having a viscosity average molecular weight of more than 100,000 and not more than 500,000, and does not contain a tackifier.
    The second adhesive sheet for skin of the present invention has an adhesive layer formed on a support, wherein the aforementioned adhesive layer contains at least a thermoplastic elastomer, and more than 120 parts by weight and not more than 800 parts by weight of non-volatile hydrocarbon oil per 100 parts by weight of the elastomer, and more than 3 parts by weight and not more than 500 parts by weight of polyisobutylene, the polyisobutylene is a mixture of a low molecular weight polyisobutylene having a viscosity average molecular weight of more than 30,000 and not more than 100,000, and a high molecular weight polyisobutylene having a viscosity average molecular weight of more than 500,000 and not more than 5,000,000, and a tackifier is not contained.
    Furthermore, a percutaneous absorption preparation containing a drug or a pharmaceutically acceptable salt thereof in an adhesive layer of the above-mentioned adhesive sheet for skin is provided.

    摘要翻译： 本发明提供一种皮肤用粘合片，其对皮肤表现出充分的粘合性并且引起低皮肤刺激性。 本发明的皮肤用第一粘合片具有在支撑体上形成的粘合剂层，其中，上述粘合剂层至少含有粘均分子量超过100,000的热塑性弹性体，不挥发性烃油和聚异丁烯， 超过50万，并且不含增粘剂。 本发明的皮肤用第二粘合片具有在支撑体上形成的粘合剂层，其中，上述粘合剂层至少含有热塑性弹性体，并且含有超过120重量份且不超过800重量份的非挥发性 烃油/ 100重量份弹性体，和大于3重量份且不大于500重量份聚异丁烯，聚异丁烯是粘均分子量大于30000的低分子量聚异丁烯 并且不超过100,000，并且粘均分子量大于500,000且不超过5,000,000的高分子量聚异丁烯，并且不含增粘剂。 此外，提供一种在上述皮肤用粘合片的粘合剂层中含有药物或其药学上可接受的盐的透皮吸收制剂。

    ADHESIVE SHEET FOR APPLICATION TO THE SKIN, AND PERCUTANEOUS ABSORPTION PREPARATION USING SAME
    6.
    发明公开
    ADHESIVE SHEET FOR APPLICATION TO THE SKIN, AND PERCUTANEOUS ABSORPTION PREPARATION USING SAME 审中-公开
    KLEBEFOLIE ZUR ANWENDUNG AUF DER HAUT UND PERKUTANESABSORPTIONSPRÄPARATDAMIT

    公开(公告)号：EP3040068A1

    公开(公告)日：2016-07-06

    申请号：EP14810664.4

    申请日：2014-06-12

    申请人： KM Transderm Ltd.

    发明人： OGINO, Hiroyuki ,  YUKIMOTO, Sadao ,  HAMADA, Atsuyo ,  AKAZAWA, Mitsuji ,  GOTO, Masaoki

    IPC分类号： A61K9/70 ,  A61K47/32 ,  A61K47/44

    CPC分类号： A61K9/7007 ,  A61K9/70 ,  A61K31/27 ,  A61K31/325 ,  A61K31/381 ,  A61K31/4168

    摘要： Provided is an adhesive sheet for adhesion to the skin, which has sufficient adhesiveness and causes low skin irritation. Moreover, provided is a transdermal absorption preparation having, in addition to the above-mentioned property, sufficient drug releaseability.
    An adhesive sheet for adhesion to the skin, which comprises a support and an adhesive layer formed on the support, wherein the adhesive layer contains at least a thermoplastic elastomer, and a non-volatile hydrocarbon oil in an amount exceeding 50 parts by weight and not more than 800 parts by weight per 100 parts by weight of the elastomer, and the thermoplastic elastomer is a mixture of a triblock copolymer and a diblock copolymer, wherein the content of the diblock copolymer in the mixture is not less than 20 wt%.

    摘要翻译： 提供了一种用于粘附到皮肤上的粘合片，其具有足够的粘合性并导致低的皮肤刺激性。 此外，提供了除了上述性质之外还具有充分的药物释放性的透皮吸收制剂。 一种用于粘合到皮肤上的粘合片，其包括支撑体和形成在所述支撑体上的粘合剂层，其中所述粘合剂层至少含有热塑性弹性体和超过50重量份的非挥发性烃油，而不是 每100重量份弹性体多于800重量份，热塑性弹性体是三嵌段共聚物和二嵌段共聚物的混合物，其中二嵌段共聚物的含量不小于20重量％。

    PATCH
    8.
    发明公开
    PATCH 审中-公开
    补丁

    公开(公告)号：EP2859892A1

    公开(公告)日：2015-04-15

    申请号：EP13803993.8

    申请日：2013-06-12

    申请人： Km Transderm Ltd.

    发明人： OGINO, Hiroyuki ,  GOTO, Masaoki ,  HAMADA, Atsuyo ,  AKAZAWA, Mitsuji ,  YUKIMOTO, Sadao

    IPC分类号： A61K31/27 ,  A61K9/70 ,  A61K47/06 ,  A61K47/32 ,  A61K47/44 ,  A61P25/28 ,  A61P43/00

    CPC分类号： A61K9/7038 ,  A61K9/7053 ,  A61K31/27 ,  A61K31/325

    摘要： The present invention provides a patch containing an adhesive layer maintaining a drug, which is formed on a support, wherein the aforementioned adhesive layer comprises a thermoplastic elastomer, a non-volatile hydrocarbon oil in an amount exceeding 50 parts by weight and not more than 800 parts by weight per 100 parts by weight of the elastomer, and rivastigmine or a salt thereof, and the aforementioned adhesive layer optionally further contains a tackifier at a content in the adhesive layer of not more than 10 wt%.

    摘要翻译： 本发明提供一种贴剂，其含有在载体上形成的维持药物的粘合剂层，其中，上述粘合剂层包含热塑性弹性体，超过50重量份且不超过800重量％的不挥发性烃油 重量份/ 100份重量的弹性体和利凡斯的明或其盐，并且上述粘合剂层任选地还包含在粘合剂层中的含量不超过10重量％的增粘剂。