公开(公告)号：EP4149442A1

公开(公告)日：2023-03-22

申请号：EP21805158.9

申请日：2021-05-12

申请人： Dong-A ST Co., Ltd. ,  KM Transderm Ltd.

发明人： JANG, Sun-Woo ,  SHIN, Chang-Yell ,  KIM, Hae-Sun ,  CHA, Kwang-Ho ,  KIM, Hyun-jung ,  HYUN, Sang-Min ,  GOTO, Masaoki

IPC分类号： A61K9/70 ,  A61K47/20 ,  A61K47/22 ,  A61K31/445 ,  A61P25/28

公开(公告)号：EP3900711A1

公开(公告)日：2021-10-27

申请号：EP19897865.2

申请日：2019-09-05

申请人： Dong-A St Co., Ltd. ,  KM Transderm Ltd.

发明人： JANG, Sun-Woo ,  SHIN, Chang-Yell ,  KIM, Hae-Sun ,  CHA, Kwang-Ho ,  KIM, Hyun-Jung ,  GOTO, Masaoki

IPC分类号： A61K9/70 ,  A61K31/445 ,  A61K47/20 ,  A61P25/28

摘要： The present invention relates to a percutaneous absorption preparation comprising donepezil for the treatment of dementia. More specifically, the present invention relates to a percutaneous absorption preparation for the treatment of dementia comprising a support layer, a drug-containing layer, and a release layer, wherein the drug-containing layer comprises donepezil or a pharmaceutically acceptable salt thereof as an active ingredient; monothioglycerol, thiocyanate metal salt (preferably potassium salt) or dimethylthiourea as a stabilizer; and a pressure-sensitive adhesive.
The present invention provides a percutaneous absorption preparation for the treatment of dementia with reduced the formation of donepezil impurities.

公开(公告)号：EP3733168A1

公开(公告)日：2020-11-04

申请号：EP18896586.7

申请日：2018-11-07

申请人： Dong-A St Co., Ltd. ,  KM Transderm Ltd.

发明人： JANG, Sun-Woo ,  SHIN, Chang-Yell ,  KIM, Jeong-Soo ,  KIM, Hae-Sun ,  CHA, Kwang-Ho ,  KIM, Hyun-Jung ,  GOTO, Masaoki

IPC分类号： A61K9/70 ,  A61K47/10 ,  A61K31/445 ,  A61P25/28

摘要： The present invention relates to a percutaneous absorption preparation comprising donepezil for treatment of dementia, wherein the preparation comprises: (a) donepezil or its pharmaceutically acceptable salt as active component, (b) propylene glycol monocaprylate as solubilizer, and (c) styrene-isoprene-styrene block copolymer ("SIS") as adhesive. The percutaneous absorption preparation according to the present invention has low skin irritation and high skin penetration.

公开(公告)号：EP4395750A1

公开(公告)日：2024-07-10

申请号：EP22865059.4

申请日：2022-09-01

申请人： Dong-A ST Co., Ltd.

发明人： JANG, Sun-Woo ,  SHIN, Chang-Yell ,  KIM, Hae-Sun ,  HYUN, Sang-Min ,  KIM, Yong-Jik ,  SHIN, Chang-Yong ,  KIM, Jae-Han

IPC分类号： A61K9/70 ,  A61K47/14 ,  A61K31/13 ,  A61P25/28

CPC分类号： A61P25/28 ,  A61K31/13 ,  A61K9/7053 ,  A61K9/7061