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公开(公告)号：EP3733168A1
公开(公告)日：2020-11-04
申请号：EP18896586.7
申请日：2018-11-07
发明人： JANG, Sun-Woo , SHIN, Chang-Yell , KIM, Jeong-Soo , KIM, Hae-Sun , CHA, Kwang-Ho , KIM, Hyun-Jung , GOTO, Masaoki
IPC分类号： A61K9/70 , A61K47/10 , A61K31/445 , A61P25/28
摘要： The present invention relates to a percutaneous absorption preparation comprising donepezil for treatment of dementia, wherein the preparation comprises: (a) donepezil or its pharmaceutically acceptable salt as active component, (b) propylene glycol monocaprylate as solubilizer, and (c) styrene-isoprene-styrene block copolymer ("SIS") as adhesive. The percutaneous absorption preparation according to the present invention has low skin irritation and high skin penetration.
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公开(公告)号：EP4149442A1
公开(公告)日：2023-03-22
申请号：EP21805158.9
申请日：2021-05-12
发明人： JANG, Sun-Woo , SHIN, Chang-Yell , KIM, Hae-Sun , CHA, Kwang-Ho , KIM, Hyun-jung , HYUN, Sang-Min , GOTO, Masaoki
IPC分类号： A61K9/70 , A61K47/20 , A61K47/22 , A61K31/445 , A61P25/28
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公开(公告)号：EP3900711A1
公开(公告)日：2021-10-27
申请号：EP19897865.2
申请日：2019-09-05
发明人： JANG, Sun-Woo , SHIN, Chang-Yell , KIM, Hae-Sun , CHA, Kwang-Ho , KIM, Hyun-Jung , GOTO, Masaoki
IPC分类号： A61K9/70 , A61K31/445 , A61K47/20 , A61P25/28
摘要： The present invention relates to a percutaneous absorption preparation comprising donepezil for the treatment of dementia. More specifically, the present invention relates to a percutaneous absorption preparation for the treatment of dementia comprising a support layer, a drug-containing layer, and a release layer, wherein the drug-containing layer comprises donepezil or a pharmaceutically acceptable salt thereof as an active ingredient; monothioglycerol, thiocyanate metal salt (preferably potassium salt) or dimethylthiourea as a stabilizer; and a pressure-sensitive adhesive.
The present invention provides a percutaneous absorption preparation for the treatment of dementia with reduced the formation of donepezil impurities.-
公开(公告)号：EP3212647B1
公开(公告)日：2019-04-03
申请号：EP15853996.5
申请日：2015-10-27
申请人： Dong-A ST Co., Ltd.
发明人： KIM, Myeong-seop , PARK, Taesun , YOON, Taeyoung , YANG, Seung Min , KIM, Hae-Sun , KIM, Jun Gyu
IPC分类号： C07D471/04 , C07D487/04 , C07D401/12 , C07D405/12 , C07D413/12 , A61K31/519 , A61K31/4375 , A61P35/00 , C07D519/00
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5.发明公开
公开(公告)号：EP4395750A1
公开(公告)日：2024-07-10
申请号：EP22865059.4
申请日：2022-09-01
申请人： Dong-A ST Co., Ltd.
发明人： JANG, Sun-Woo , SHIN, Chang-Yell , KIM, Hae-Sun , HYUN, Sang-Min , KIM, Yong-Jik , SHIN, Chang-Yong , KIM, Jae-Han
CPC分类号： A61P25/28 , A61K31/13 , A61K9/7053 , A61K9/7061
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6.发明公开NOVEL PYRIDOPYRIMIDINONE COMPOUNDS FOR MODULATING THE CATALYTIC ACTIVITY OF HISTONE LYSINE DEMETHYLASES (KDMS) 审中-公开调节活性赖氨酸二甲酯（KDMS）催化活性的新型吡啶并嘧啶酮化合物
公开(公告)号：EP3212647A2
公开(公告)日：2017-09-06
申请号：EP15853996.5
申请日：2015-10-27
申请人： Dong-A ST Co., Ltd.
发明人： KIM, Myeong-seop , PARK, Taesun , YOON, Taeyoung , YANG, Seung Min , KIM, Hae-Sun , KIM, Jun Gyu
IPC分类号： C07D471/04 , C07D487/04 , C07D401/12 , C07D405/12 , C07D413/12 , A61K31/519 , A61K31/4375 , A61P35/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention provides a compound of Formula (I) being capable of modulating the activity of histone lysine demethylase (KDM), pharmaceutical compositions thereof, methods to prepare the said compounds, and the use of such compounds as a medicament. The compound of Formula (I) acts as KDM inhibitor with marked potency, thereby having an outstanding potential for a pharmaceutical intervention of cancer and any other diseases related to KDM dysregulation.
摘要翻译： 本发明提供能够调节组蛋白赖氨酸脱甲基酶（KDM）活性的式（I）化合物，其药物组合物，制备所述化合物的方法以及这些化合物作为药物的用途。 式（I）化合物作为具有显着效力的KDM抑制剂起作用，因此具有用于癌症和任何其他与KDM失调相关的疾病的药物干预的显着潜力。
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