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    METHOD ENABLING USE OF EXTRACELLULAR RNA EXTRACTED FROM PLASMA OR SERUM TO DETECT, MONITOR OR EVALUATE CANCER
    2.
    发明公开
    METHOD ENABLING USE OF EXTRACELLULAR RNA EXTRACTED FROM PLASMA OR SERUM TO DETECT, MONITOR OR EVALUATE CANCER 失效
    血浆或血清中提取RNA EXTRAZELLURAERE诊断监测和癌症的评价方法采用

    公开(公告)号：EP0938320A1

    公开(公告)日：1999-09-01

    申请号：EP97915870.0

    申请日：1997-03-14

    申请人： Kopreski, Michael, S.

    发明人： Kopreski, Michael, S.

    IPC分类号： C12Q1

    CPC分类号： C12Q1/6806 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  Y10T436/143333 ,  C12Q2521/119

    摘要： This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may circulate as non-bound RNA, protein-bound RNA, lipid-RNA complexes, lipoprotein (proteolipid) - RNA complexes, protein-RNA complexes including within or in association with ribonucleoprotein complexes, nucleosomes, or within apoptotic bodies. Any intracellular RNA found in plasma or serum can additionally be detected by this invention. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any neoplasm, benign, premalignant, or malignant, in humans or other animals, which might be associated with that RNA. Further, this invention allows the qualitative or quantitative detection of tumor-derived or associated extracellular RNA circulating in the plasma or serum of humans or animals with or without any prior knowledge of the presence of cancer or premalignant tissue.

    METHOD ENABLING USE OF EXTRACELLULAR RNA EXTRACTED FROM PLASMA OR SERUM TO DETECT, MONITOR OR EVALUATE CANCER
    4.
    发明授权
    METHOD ENABLING USE OF EXTRACELLULAR RNA EXTRACTED FROM PLASMA OR SERUM TO DETECT, MONITOR OR EVALUATE CANCER 失效
    使用从血浆或血清中提取的细胞外RNA来检测，监测或评估癌症的方法

    公开(公告)号：EP0938320B9

    公开(公告)日：2010-11-03

    申请号：EP97915870.6

    申请日：1997-03-14

    申请人： Kopreski, Michael, S.

    发明人： Kopreski, Michael, S.

    IPC分类号： A61K31/70 ,  A61K39/395 ,  C12P19/34 ,  C12Q1/68 ,  C12Q1/70

    CPC分类号： C12Q1/6806 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  Y10T436/143333 ,  C12Q2521/119

    摘要： This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may circulate as non-bound RNA, protein-bound RNA, lipid-RNA complexes, lipoprotein (proteolipid) - RNA complexes, protein-RNA complexes including within or in association with ribonucleoprotein complexes, nucleosomes, or within apoptotic bodies. Any intracellular RNA found in plasma or serum can additionally be detected by this invention. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any neoplasm, benign, premalignant, or malignant, in humans or other animals, which might be associated with that RNA. Further, this invention allows the qualitative or quantitative detection of tumor-derived or associated extracellular RNA circulating in the plasma or serum of humans or animals with or without any prior knowledge of the presence of cancer or premalignant tissue.

    摘要翻译： 本发明涉及在血浆或血清部分循环中发现的肿瘤衍生的或相关的细胞外核糖核酸（RNA）用于癌症或恶化前病症的检测，监测或评估的用途。 胞外RNA可作为非结合RNA，蛋白结合RNA，脂质-RNA复合物，脂蛋白（蛋白脂质）-RNA复合物，蛋白质-RNA复合物（包括核糖核蛋白复合物内或与核蛋白复合物相关联），核小体或凋亡小体内循环。 本发明还可以检测到血浆或血清中发现的任何细胞内RNA。 具体而言，本发明能够从血浆或血清中提取循环RNA，并且利用核酸扩增测定法对人类或其他动物中的任何新生物，良性，恶变前或恶性肿瘤进行鉴定，检测，推断，监测或评估，其 可能与该RNA有关。 此外，本发明允许定性或定量检测人或动物血浆或血清中循环的肿瘤来源或相关细胞外RNA，具有或不具有癌症或癌前组织的存在的任何现有知识。

    METHOD ENABLING USE OF EXTRACELLULAR RNA EXTRACTED FROM PLASMA OR SERUM TO DETECT, MONITOR OR EVALUATE CANCER
    5.
    发明授权
    METHOD ENABLING USE OF EXTRACELLULAR RNA EXTRACTED FROM PLASMA OR SERUM TO DETECT, MONITOR OR EVALUATE CANCER 失效
    血浆或血清中提取RNA EXTRAZELLURAERE诊断监测和癌症的评价方法采用

    公开(公告)号：EP0938320B1

    公开(公告)日：2010-06-16

    申请号：EP97915870.6

    申请日：1997-03-14

    申请人： Kopreski, Michael, S.

    发明人： Kopreski, Michael, S.

    IPC分类号： A61K31/70 ,  A61K39/395 ,  C12P19/34 ,  C12Q1/68 ,  C12Q1/70

    CPC分类号： C12Q1/6806 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  Y10T436/143333 ,  C12Q2521/119

    摘要： This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may circulate as non-bound RNA, protein-bound RNA, lipid-RNA complexes, lipoprotein (proteolipid) - RNA complexes, protein-RNA complexes including within or in association with ribonucleoprotein complexes, nucleosomes, or within apoptotic bodies. Any intracellular RNA found in plasma or serum can additionally be detected by this invention. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any neoplasm, benign, premalignant, or malignant, in humans or other animals, which might be associated with that RNA. Further, this invention allows the qualitative or quantitative detection of tumor-derived or associated extracellular RNA circulating in the plasma or serum of humans or animals with or without any prior knowledge of the presence of cancer or premalignant tissue.