PD-1 PEPTIDE INHIBITORS
    4.
    发明公开

    公开(公告)号:EP3795167A1

    公开(公告)日:2021-03-24

    申请号:EP20204314.7

    申请日:2017-09-15

    申请人: Leidos, Inc.

    摘要: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.