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1.发明公开
公开(公告)号：EP3977120A1
公开(公告)日：2022-04-06
申请号：EP20728516.4
申请日：2020-06-02
发明人： STUECKEMANN, Tom , GERSTNER, Norman
IPC分类号： G01N33/50 , B82Y99/00 , G01N27/414 , G01N33/53 , H01L29/16
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公开(公告)号：EP3443624A1
公开(公告)日：2019-02-20
申请号：EP16719291.3
申请日：2016-04-14
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公开(公告)号：EP3368694A1
公开(公告)日：2018-09-05
申请号：EP16801387.8
申请日：2016-10-28
CPC分类号： C12N15/86 , C07K14/025 , C12N2710/00023 , C12N2710/14143 , C12N2710/22022 , C12N2710/22023 , C12N2710/22042 , C12N2810/40 , C12Q1/6806 , C12Q1/686 , C12Q1/708 , C12Q2545/101
摘要： A method of using a virus-like particle from a polyomavirus having a first nucleic acid as a cargo to detect a second nucleic acid. The method includes providing the virus-like particle from the polyomavirus having the first nucleic acid as the cargo, and detecting, via the virus-like particle from the polyomavirus, the second nucleic acid.
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4.发明公开
公开(公告)号：EP3230307A1
公开(公告)日：2017-10-18
申请号：EP15832732.0
申请日：2015-12-08
IPC分类号： C07K14/005 , C07K14/01 , C12N7/04
CPC分类号： C07K14/01 , C07K2/00 , C07K14/005 , C07K2319/01 , C12N7/04 , C12N2710/22022 , C12N2710/22023 , C12N2710/22042 , C12N2810/40
摘要： The disclosure relates to a fusion protein comprising at least a first and a second peptide, wherein - the second peptide comprises a targeting region and a first and a second interaction region, - the second peptide is located on the surface of the fusion protein; - the second peptide comprises at least two interaction pairs, wherein an interaction pair is formed by an amino acid of the first interaction region and an amino acid of the second interaction region, - the interaction between the amino acids of an interaction pair is covalent or noncovalent; and - at least one interaction pair is a covalent interaction pair in which the amino acids are covalently bound, and to virus like particles (VLP) comprising the fusion protein for use as drug delivery system. Also provided are polynucleotides encoding the fusion protein, suitable expression vectors, host cells, production methods for the fusion protein and the VLP comprising the fusion protein.
摘要翻译： 本公开涉及包含至少第一和第二肽的融合蛋白，其中 - 第二肽包含靶向区和第一和第二相互作用区， - 第二肽位于融合蛋白的表面上; - 第二肽包含至少两个相互作用对，其中相互作用对由第一相互作用区的氨基酸和第二相互作用区的氨基酸形成， - 相互作用对的氨基酸之间的相互作用是共价键或 非共价的; 和 - 至少一个相互作用对是其中氨基酸共价结合的共价相互作用对，并且是包含用作药物递送系统的融合蛋白的病毒样颗粒（VLP）。 还提供了编码融合蛋白的多核苷酸，合适的表达载体，宿主细胞，融合蛋白的生产方法和包含融合蛋白的VLP。
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5.发明公开Verfahren zur Bestimmung des DNA-Methylierungsgrades 审中-公开Verfahren zur Bestimmund des DNA-Methylierungsgrades
公开(公告)号：EP2746403A1
公开(公告)日：2014-06-25
申请号：EP12199152.5
申请日：2012-12-21
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2563/131 , C12Q2600/154
摘要： Verfahren zur Bestimmung des normierten DNA-Methylierungsgrads eines DNA-Abschnitts, der nur an einem Genlocus vorkommt, in einer Probe genomischer DNA umfassend die Schritte:
a) Quantitative Bestimmung der Gegenwart des DNA-Abschnitts in der Probe;
b) Quantitative Bestimmung des Vorliegens von zumindest einem differentiell methylierten C eines CpG Dinukleotids innerhalb des DNA-Abschnitts und
c) Bestimmung des normierten DNA-Methylierungsgrads des DNA-Abschnitts über die in den Schritten a) und b) bestimmten Werte.摘要翻译： 确定仅在基因组DNA样品的一个基因座处发生的DNA片段的标准DNA甲基化程度包括（a）定量测定样品中DNA片段的存在，（b）定量测定在 在DNA片段内的胞苷 - 胍二核苷酸（CpG）的至少一个差异甲基化的胞苷，和（c）测定DNA片段的标准DNA甲基化程度超过步骤（a）和（b）中确定的值。 包括用于确定相对DNA甲基化程度的独立权利要求，其包括（a1）第一基因组DNA和第二基因组DNA的甲基化程度的测定，以及通过第一和第二基因组DNA的比例特异性甲基化度测定相对DNA甲基化度 第二个DNA。
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公开(公告)号：EP3968853A1
公开(公告)日：2022-03-23
申请号：EP20761276.3
申请日：2020-08-28
发明人： KLETT, Kevin , LUTZ, Florian , HOFMEISTER, Julian
IPC分类号： A61B5/024
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公开(公告)号：EP3909612A1
公开(公告)日：2021-11-17
申请号：EP20174156.8
申请日：2020-05-12
发明人： KÜBELBECK, Armin
IPC分类号： A61K47/69
摘要： The disclosure relates to a composition of nanoparticles as carrier for pharmaceutically acceptable compounds, a method for the preparation of the composition and the use of the composition for medical purposes, in particular for immunoprophylaxis or immunotherapy. The invention also relates to a vaccine containing the composition.
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8.发明授权HUMAN TRYPSINOGEN WITH REDUCED AUTOACTIVATION AND ITS USE IN AN IMMUNOASSAY 有权减少自体激活的人胰蛋白酶原及其在免疫测定中的应用
公开(公告)号：EP3052623B1
公开(公告)日：2018-02-21
申请号：EP14781104.6
申请日：2014-09-25
发明人： BÜTTNER, Karin , PRASSE, Agneta , ZÜCHNER, Thole
IPC分类号： C12N9/76 , C12Q1/37 , G01N33/542 , G01N33/58
CPC分类号： C12N9/6427 , C12Q1/37 , C12Y304/21004 , G01N33/542
摘要： The present invention relates to a polypeptide consisting of or comprising a variant of human trypsinogen-1, wherein the variant is characterized in that an amino acid residue selected from A16, A17, K64, K138, N139, L142 and L147 is replaced by an amino acid residue with a negatively charged side chain and/or H18 is replaced by a glutamine or asparagine residue and/or L107 is replaced by an amino acid residue with a positively charged side chain and/or N139 is replaced by an amino acid residue with an aromatic side chain, wherein the variant is cleavable into a polypeptide having a native-like enzymatic activity when compared to human trypsin-1. The present invention further relates to means and method for manufacturing the polypeptide as well as the use of the polypeptide, particularly in an immunoassay.
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公开(公告)号：EP3031821A1
公开(公告)日：2016-06-15
申请号：EP14196847.9
申请日：2014-12-08
IPC分类号： C07K14/005 , C12N7/04
CPC分类号： C07K14/005 , C07K2319/06 , C07K2319/70 , C12N7/00 , C12N7/04 , C12N15/113 , C12N2310/14 , C12N2320/32 , C12N2710/22022 , C12N2710/22023 , C12N2710/22042
摘要： The disclosure relates to a fusion protein comprising a VP1 binding protein and an exogenous peptide, wherein the exogenous peptide comprises a cargo-securing peptide (CSP) and/or an endosome translocating peptide (ETP) and to virus like particles (VLP) comprising the fusion protein for use as drug delivery system.
Also provided are polynucleotides encoding the fusion protein, suitable expression vectors, host cells, production methods for the fusion protein and the VLP comprising the fusion protein.摘要翻译： 本公开涉及包含VP1结合蛋白和外源肽的融合蛋白，其中所述外源肽包含货物确保肽（CSP）和/或内体易位肽（ETP）和包含病毒样颗粒（VLP）的病毒样颗粒（VLP） 融合蛋白用作药物递送系统。 还提供了编码融合蛋白的多核苷酸，合适的表达载体，宿主细胞，融合蛋白的产生方法和包含融合蛋白的VLP。
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10.发明公开
公开(公告)号：EP3031820A1
公开(公告)日：2016-06-15
申请号：EP14196845.3
申请日：2014-12-08
IPC分类号： C07K14/005 , C07K14/01 , C12N7/04
CPC分类号： C07K14/01 , C07K2/00 , C07K14/005 , C07K2319/01 , C12N7/04 , C12N2710/22022 , C12N2710/22023 , C12N2710/22042 , C12N2810/40
摘要： The disclosure relates to a fusion protein comprising at least a first and a second peptide, wherein
- the second peptide comprises a targeting region and a first and a second interaction region,
- the second peptide is located on the surface of the fusion protein;
- the second peptide comprises at least two interaction pairs, wherein an interaction pair is formed by an amino acid of the first interaction region and an amino acid of the second interaction region,
- the interaction between the amino acids of an interaction pair is covalent or noncovalent; and
- at least one interaction pair is a covalent interaction pair in which the amino acids are covalently bound,
and to virus like particles (VLP) comprising the fusion protein for use as drug delivery system.
Also provided are polynucleotides encoding the fusion protein, suitable expression vectors, host cells, production methods for the fusion protein and the VLP comprising the fusion protein.摘要翻译： 本公开涉及包含至少第一和第二肽的融合蛋白，其中 - 所述第二肽包含靶向区和第一和第二相互作用区，所述第二肽位于所述融合蛋白的表面上; - 第二肽包含至少两个相互作用对，其中相互作用对由第一相互作用区域的氨基酸和第二相互作用区域的氨基酸形成， - 相互作用对的氨基酸之间的相互作用是共价的或 非共价键; 和 - 至少一个相互作用对是氨基酸共价结合的共价相互作用对，以及包含用作药物递送系统的融合蛋白的病毒样颗粒（VLP）。 还提供了编码融合蛋白的多核苷酸，合适的表达载体，宿主细胞，融合蛋白的产生方法和包含融合蛋白的VLP。
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