PURIFICATION OF TRAMADOL
    4.
    发明公开
    PURIFICATION OF TRAMADOL 审中-公开
    REINIGUNG VON TRAMADOL

    公开(公告)号:EP1047662A1

    公开(公告)日:2000-11-02

    申请号:EP99901000.2

    申请日:1999-01-14

    IPC分类号: C07C213/10 C07C215/42

    摘要: A process for the preparation of Tramadol according to a Grignard reaction of 2(dimethylaminomethyl)cyclo-hexanone with the reagent 3-methoxyphenylMgX, where X is a halogen, to obtain the crude base which is then introduced to a solvent, comprises contacting the crude base with hydrobromic or hydriodic acid to form a salt thereof, and subjecting the salt to a re-crystallisation step to obtain the product Tramadol hydrobromide or Tramadol hydriodide respectively, from which purified Tramadol base is obtainable for optional conversion to a pharmaceutically preferred form e.g. Tramadol hydrochloride.

    摘要翻译: 根据2(二甲基氨基甲基)环己酮与试剂3-甲氧基苯基M gX(其中X为卤素)的格利雅反应制备曲马多的方法,得到粗碱,然后将其引入溶剂中, 用氢溴酸或氢碘酸碱化以形成其盐,并且对盐进行再结晶步骤,分别得到产物Tramadol氢溴酸盐或曲马多氢碘酸盐,从中可以获得纯化的曲马多碱,用于任选转化成药学上优选的形式,例如 盐酸曲马多

    PROCESS FOR THE PREPARATION OF MORPHINAN-6-ONE COMPOUNDS

    公开(公告)号:EP4174072A2

    公开(公告)日:2023-05-03

    申请号:EP22204999.1

    申请日:2014-02-05

    IPC分类号: C07D489/08

    摘要: The present provides a process for preparing a compound of formula (3), the process comprising the steps of:
    (a) providing an aqueous acidic solution comprising a compound of formula (1) and, as an impurity, a compound of formula (2); and
    (b) treating the aqueous acidic solution of step (a) such that the compound of formula (2) dehydrates to form a compound of formula (1) and the compound of formula (1) is reduced to form an aqueous acidic solution of the compound of formula (3),


    wherein:
    the treating of step (b) is carried out at one or more temperatures greater than ambient in the presence of a hydrogenation catalyst and hydrogen gas; and
    wherein for the compounds of formulae (1), (2) and (3):
    i) R 1 is -OH, R 2 is -OH and R 3 -H; or
    ii) R 1 is -OCH 3 , R 2 is -H and R 3 -CH 3 ; or
    iii) R 1 is -OH, R 2 is -H and R 3 -CH 3 ; or
    iv) R 1 is -OCH 3 , R 2 is -H and R 3 -H; or
    v) R 1 is -OH, R 2 is -H and R 3 -H; or
    vi) R 1 is -OCH 3 , R 2 is -OH and R 3 -H.

    HYDROCARBON LIQUID FORMULATION
    6.
    发明公开
    HYDROCARBON LIQUID FORMULATION 有权
    烃类液体配方

    公开(公告)号:EP1080165A1

    公开(公告)日:2001-03-07

    申请号:EP99922304.3

    申请日:1999-05-13

    IPC分类号: C10L1/14

    摘要: A liquid hydrocarbon is rendered unpalatable by introducing thereto a denaturant suitable for discouraging the ingestion of the hydrocarbon liquid, but hitherto presenting difficulties in achieving that purpose, particularly with paraffinic liquids such as lamp oil, white spirit, kerosene and other hydrocarbon solvents, wherein the denaturant is a denatonium compound, preferably denatonium benzoate, or an analogue or derivative thereof exhibiting similar organoleptic effects, and using a sufficient amount of a liquid stabiliser miscible with said hydrocarbon liquid, e.g. an alkanol or derivative thereof, to obtain a stable solution or suspension of said denaturant in said liquid hydrocarbon.

    PROCESS FOR THE PREPARATION OF MORPHINAN-6-ONE COMPOUNDS

    公开(公告)号:EP4174072A3

    公开(公告)日:2023-07-19

    申请号:EP22204999.1

    申请日:2014-02-05

    IPC分类号: C07D489/08

    摘要: The present provides a process for preparing a compound of formula (3), the process comprising the steps of:
    (a) providing an aqueous acidic solution comprising a compound of formula (1) and, as an impurity, a compound of formula (2); and
    (b) treating the aqueous acidic solution of step (a) such that the compound of formula (2) dehydrates to form a compound of formula (1) and the compound of formula (1) is reduced to form an aqueous acidic solution of the compound of formula (3),


    wherein:
    the treating of step (b) is carried out at one or more temperatures greater than ambient in the presence of a hydrogenation catalyst and hydrogen gas; and
    wherein for the compounds of formulae (1), (2) and (3):
    i) R 1 is -OH, R 2 is -OH and R 3 -H; or
    ii) R 1 is -OCH 3 , R 2 is -H and R 3 -CH 3 ; or
    iii) R 1 is -OH, R 2 is -H and R 3 -CH 3 ; or
    iv) R 1 is -OCH 3 , R 2 is -H and R 3 -H; or
    v) R 1 is -OH, R 2 is -H and R 3 -H; or
    vi) R 1 is -OCH 3 , R 2 is -OH and R 3 -H.

    HYDROCARBON LIQUID FORMULATION
    9.
    发明授权
    HYDROCARBON LIQUID FORMULATION 有权
    烃类液体配方

    公开(公告)号:EP1080165B1

    公开(公告)日:2004-01-21

    申请号:EP99922304.3

    申请日:1999-05-13

    IPC分类号: C10L1/14

    摘要: A liquid hydrocarbon is rendered unpalatable by introducing thereto a denaturant suitable for discouraging the ingestion of the hydrocarbon liquid, but hitherto presenting difficulties in achieving that purpose, particularly with paraffinic liquids such as lamp oil, white spirit, kerosene and other hydrocarbon solvents, wherein the denaturant is a denatonium compound, preferably denatonium benzoate, or an analogue or derivative thereof exhibiting similar organoleptic effects, and using a sufficient amount of a liquid stabiliser miscible with said hydrocarbon liquid, e.g. an alkanol or derivative thereof, to obtain a stable solution or suspension of said denaturant in said liquid hydrocarbon.