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1.发明公开ANDROGEN-RECEPTOR (AR) LIGANDS FOR USE IN THE TREATMENT AND DIAGNOSIS OF AR-RELATED PATHOLOGIES 审中-公开雄激素受体（AR）的配体用于治疗和诊断AR相关疾病
公开(公告)号：EP1957059A1
公开(公告)日：2008-08-20
申请号：EP06809888.8
申请日：2006-11-21
申请人： HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , Medical Research Fund at the Tel Aviv Sourasky Medical Center
IPC分类号： A61K31/165 , A61P5/28 , A61K51/04 , C07C237/02
CPC分类号： A61K51/04 , C07B2200/05 , C07C237/04 , C07C255/60
摘要： The present invention discloses novel compounds and compositions suitable for the treatment of androgen related pathologies. The invention also provides diagnostic compositions for the diagnosis or monitoring of such androgen pathologies.
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2.发明公开METHODS AND KITS FOR PREDICTING LIVER FIBROSIS PROGRESSION RATE IN CHRONIC HEPATITIS C PATIENTS 审中-公开方法和药盒预测肝纤维化的FORT违约率在慢性丙型肝炎患者
公开(公告)号：EP1778861A2
公开(公告)日：2007-05-02
申请号：EP05756877.6
申请日：2005-06-30
发明人： OREN, Ran
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172
摘要： Methods and kits for determining predisposition of an individual to develop fast progression rate of liver fibrosis are provided. Also provided are agents and pharmaceutical compositions useful in preventing fast progression of liver fibrosis and a method of identifying drug molecules which accelerate or induce liver fibrosis.
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3.发明公开USE OF NON-CATALYTIC FORM OF HEPARANASE AND PEPTIDES THEREOF FOR REVERSING THE ANTI-COAGULANT EFFECTS OF HEPARINOIDS 审中-公开乙酰肝素酶和多肽非催化FORM OF及其用于逆转抗凝血类肝素的地方使用
公开(公告)号：EP2029161A2
公开(公告)日：2009-03-04
申请号：EP07736304.2
申请日：2007-05-10
申请人： Hadasit Medical Research Services & Development Ltd. , The Medical Research Fund at the Tel-Aviv Sourasky Medical Center
CPC分类号： A61K38/47
摘要： The present invention relates to inhibition of heparinoids anti-coagulation activity by a non-active form of a eukaryotic endoglycosidase or any fragment or peptide thereof comprising at least one heparin-binding domain. More particularly, the invention provides compositions and methods for the inhibition of heparinoids anti-coagulation activity and for the treatment of coagulation related pathologic clinical conditions, using a non-active form of mammalian heparanase or peptides thereof comprising at least one heparin-binding domain.
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4.发明公开METHOD AND COMPOSITION FOR MODULATION OF SYSTEMIC INFLAMMATORY RESPONSES SYNDROME (SIRS) 有权调制全身炎症反应综合征的方法和组合物（SIRS）
公开(公告)号：EP1784200A1
公开(公告)日：2007-05-16
申请号：EP05773761.1
申请日：2005-08-16
发明人： SORKINE, Patrick , FROLKIS, Ina , LOCKER, Chaim
CPC分类号： A61K35/583
摘要： The present invention relates to pharmaceutical composition comprising animal venom and using same in a method for the treatment of Systemic Inflammatory Response Syndrome (SIRS) and related pathologies.
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5.发明授权METHOD AND COMPOSITION FOR MODULATION OF SYSTEMIC INFLAMMATORY RESPONSES SYNDROME (SIRS) 有权调制全身炎症反应综合征的方法和组合物（SIRS）
公开(公告)号：EP1784200B1
公开(公告)日：2011-04-20
申请号：EP05773761.1
申请日：2005-08-16
发明人： SORKINE, Patrick , FROLKIS, Ina , LOCKER, Chaim
CPC分类号： A61K35/583
摘要： The present invention relates to pharmaceutical composition comprising animal venom and using same in a method for the treatment of Systemic Inflammatory Response Syndrome (SIRS) and related pathologies.
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