公开(公告)号：EP3347055B1

公开(公告)日：2019-06-12

申请号：EP17715654.4

申请日：2017-03-29

申请人： Midatech Ltd.

发明人： COULTER, Tom ,  DAMMENT, Stephen ,  PACE, Alessandro ,  PALMER, Daniel

IPC分类号： A61K47/69 ,  A61K47/40

公开(公告)号：EP3347055A1

公开(公告)日：2018-07-18

申请号：EP17715654.4

申请日：2017-03-29

申请人： Midatech Ltd.

发明人： COULTER, Tom ,  DAMMENT, Stephen ,  PACE, Alessandro ,  PALMER, Daniel

IPC分类号： A61K47/69 ,  A61K47/40

CPC分类号： A61K47/40 ,  A61K31/4045 ,  A61K47/6951 ,  C08B37/0015

摘要： The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.

公开(公告)号：EP3893938A1

公开(公告)日：2021-10-20

申请号：EP19829067.8

申请日：2019-12-13

申请人： Midatech Ltd

发明人： MCATEER, Martina ,  COULTER, Tom ,  DING, Yao ,  PORTER, John

IPC分类号： A61K47/69 ,  A61K47/54 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00

公开(公告)号：EP3893939A1

公开(公告)日：2021-10-20

申请号：EP19831633.3

申请日：2019-12-13

申请人： Midatech Ltd

发明人： MCATEER, Martina ,  COULTER, Tom ,  DING, Yao ,  PORTER, John ,  KOLIOS, Antonios G. A. ,  BOYMAN, Onur ,  ÖZCAN, Alaz

IPC分类号： A61K47/69 ,  A61K47/54 ,  A61P29/00 ,  A61P37/00