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17 条记录 (耗时 0.017 秒)

    DETECTION OF CLEAVAGE ACTIVITY OF AN ENZYME
    3.
    发明公开
    DETECTION OF CLEAVAGE ACTIVITY OF AN ENZYME 审中-公开
    NACHWEIS DERSPALTUNGSAKTIVITÄTEINES ENZYMS

    公开(公告)号：EP3060915A2

    公开(公告)日：2016-08-31

    申请号：EP14790689.5

    申请日：2014-10-23

    申请人： Mologic Limited

    发明人： DAVIS, Paul ,  PAREKH, Gita ,  SCHOUTEN, James

    IPC分类号： G01N33/543 ,  C12Q1/37 ,  G01N33/573

    CPC分类号： G01N33/54386 ,  C12Q1/37 ,  G01N33/558 ,  G01N2333/96486 ,  G01N2800/12 ,  G01N2800/382

    摘要： The present invention relates to detecting cleavage activity of an enzyme. The various aspects of the invention include an enzyme detection device, kit, method and use for detecting or measuring the presence in a test sample of the activity of an enzyme capable of cleaving a substrate. The invention also relates to indicator and binding molecules useful for carrying out the invention. The enzyme substrate contains a hidden binding site which is only revealed upon cleavage by the enzyme.

    摘要翻译： 本发明涉及检测酶的切割活性。 本发明的各个方面包括酶检测装置，试剂盒，方法和用于检测或测量在测试样品中能够裂解底物的酶的活性的存在。 本发明还涉及用于实施本发明的指示剂和结合分子。 酶底物含有隐藏的结合位点，其仅在通过酶切割时显露。

    DIAGNOSTIC TEST WITH LATERAL FLOW TEST STRIP
    5.
    发明公开
    DIAGNOSTIC TEST WITH LATERAL FLOW TEST STRIP 审中-公开

    公开(公告)号：EP3380237A1

    公开(公告)日：2018-10-03

    申请号：EP16804862.7

    申请日：2016-11-23

    申请人： Mologic Limited

    发明人： PAREKH, Gita

    IPC分类号： B01L3/00

    摘要： The apparatus may be included in a kit of parts. The apparatus is useful for detecting peritonitis. The bulk source of fluid may be peritoneal dialysate. Various markers may be determined in the bulk source of fluid such as MMP8, IL-6, HNE, MMP2, MMP9, TIMP1, TIMP2, NGAL, A1AT, desmosine, fibrinogen, IL-8, calprotectin, fMLP, IL1b, cystatin C, HSA, RBP4, SPD, MPO, sICAM and TNFa. Detection of the markers to indicate peritonitis may also inform treatment choices.

    MONITORING INFLAMMATION STATUS
    7.
    发明公开
    MONITORING INFLAMMATION STATUS 审中-公开
    ÜBERWACHUNGDESENTZÜNDUNGSSTATUS

    公开(公告)号：EP3111226A1

    公开(公告)日：2017-01-04

    申请号：EP15708260.3

    申请日：2015-03-02

    申请人： Mologic Limited

    发明人： PAREKH, Gita ,  DAVIS, Paul

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6893 ,  G01N33/6863 ,  G01N2800/12 ,  G01N2800/7095

    摘要： Methods for monitoring inflammation status of a subject comprise determining levels of at least one neutrophil activation marker, or at least three markers, in urine samples taken from the subject at multiple time points, wherein increased levels of the at least one neutrophil activation marker, or at least one of the markers, in a urine sample are indicative of or predictive of an exacerbation of inflammation and/or wherein decreased levels of the at least one neutrophil activation marker, or at least one of the markers, in a urine sample following an increase are indicative or predictive of recovery from, or successful treatment of, an exacerbation of inflammation. Corresponding systems, test kits and computer programs are provided.

    摘要翻译： 用于监测受试者的炎症状态的方法包括确定在多个时间点取自受试者的尿液样本中至少一种嗜中性粒细胞活化标记物或至少三种标记物的水平，其中增加至少一种嗜中性粒细胞活化标记物的水平，或 尿液样本中的至少一个标记指示或预测炎症加重和/或其中至少一种嗜中性粒细胞活化标记物或至少一种标记物在尿样中的水平降低 增加是指示或预测炎症恶化的恢复或成功治疗。 提供相应的系统，测试工具包和计算机程序。