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公开(公告)号：EP4353258A1
公开(公告)日：2024-04-17
申请号：EP22804761.9
申请日：2022-05-19
发明人： TOBE, Kazuyuki , KADO, Tomonobu , OZAWA, Tatsuhiko , MORI, Hisashi , YOSHIDA, Tomoyuki , IGARASHI, Yoshiko
IPC分类号： A61K45/00 , A61K39/395 , A61P35/00 , A61P43/00 , C07K16/28 , C07K16/46 , C12N15/13 , C12P21/08
摘要： An object of the present invention is to reveal association of macrophages with the development/progression of a cancer, and to provide a novel pharmaceutical composition for the prevention or treatment of a cancer. The present invention provides a pharmaceutical composition for the prevention or treatment of a cancer; a composition for killing fibroblasts locating adjacent to a tumor tissue; a composition for promoting infiltration of cytotoxic T cells into a tumor tissue; a composition for suppressing the expression of a gene(s) in fibroblasts, which gene(s) suppress(es) infiltration of cytotoxic T cells into a tumor; a composition for promoting the growth of cytotoxic T cells; a composition for enhancing the cytotoxic activity of cytotoxic T cells; and a composition for enhancing the expression of a gene(s) associated with the cytotoxicity of cytotoxic T cells; containing, as an effective component, a substance having an ability to kill CD206-positive M2 macrophages.
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2.发明公开
公开(公告)号：EP4261226A1
公开(公告)日：2023-10-18
申请号：EP21903514.4
申请日：2021-12-10
IPC分类号： C07K16/40 , C12N15/06 , C12N15/13 , C12Q1/48 , C12Q1/6848 , C12Q1/6876 , C12P21/08
摘要： Provided is an antibody that inhibits the 5' to 3' exonuclease activity of a DNA polymerase, or a fragment thereof.
Disclosed is an antibody that specifically binds to a 5' to 3' exonuclease domain of a DNA polymerase, or a fragment thereof.-
公开(公告)号：EP4260882A1
公开(公告)日：2023-10-18
申请号：EP21906311.2
申请日：2021-11-29
申请人： Nitto Seiko Co., Ltd. , Kyoto Prefectural Public University Corporation , National University Corporation University Of Toyama , Tsutsumi, Sadami
发明人： ISHIHARA, Masakazu , UENO, Yoshimitsu , MURATA, Tomoaki , OTSUKI, Yukito , KOBAYASHI, Yusuke , OKA, Yoshinobu , AIDA, Tetsuo , KIM, Wook-Cheol , TSUTSUMI, Sadami
摘要： To ensure that a biodegradable medical implement dissolves in vivo at an appropriate dissolution rate.
The biodegradable medical implement of the present invention is formed of a magnesium material, and, at least in one transverse section, a layer of magnesium crystal grains in which a (0001) plane in a hexagonal crystal structure is oriented toward a surface side is continuous over an entire circumference.-
公开(公告)号：EP4257146A1
公开(公告)日：2023-10-11
申请号：EP21900451.2
申请日：2021-11-24
IPC分类号： A61K45/00 , A61K31/517 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K39/395 , A61P35/00 , A61P35/02 , A61P43/00 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/113 , C12N15/115 , C12N15/12 , C12Q1/68 , G01N33/53 , G01N33/574
摘要： A pharmaceutical composition for preventing or treating cystic lymphangioma comprising an agent that causes suppression of expression of amphiregulin, suppression of secretion of amphiregulin, and/or inhibition of binding of amphiregulin with an amphiregulin receptor, or an agent that causes suppression of expression of an amphiregulin receptor, suppression of activation of an amphiregulin receptor, and/or inhibition of binding of an amphiregulin receptor with amphiregulin, as an active ingredient.
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公开(公告)号：EP4183424A1
公开(公告)日：2023-05-24
申请号：EP20958690.8
申请日：2020-10-22
发明人： AMANO Kouji , YOSHIDA Toshiko , OKABE Motonori , SOKO Chika , ARAKAWA Masahiko
摘要： The present invention addresses the problem of providing a wound contact member (or "contact layer") that directly promotes wound healing when continuously performing negative pressure wound therapy (NPWT). As a solution, there is provided dry amniotic membrane manufactured by a specified drying process, that is, raw amniotic membrane placed inside a processing tank (10) is continuously heated using an infrared heater (14) provided inside the processing tank (10) while performing a depressurization operation that places the processing tank in a depressurized state and irradiation of the raw amniotic membrane with microwaves from a microwave generating device (30) provided inside the processing tank (10) to apply energy to water molecules present inside the amniotic membrane and cause drying during a pressure recovery operation that slightly raises the pressure inside the depressurized processing tank (10) toward atmospheric pressure. Amniotic membrane, which has been dried by repeating the above process and thereby retains its cell and tissue structure, is used as a contact layer when performing negative pressure wound therapy (NPWT) on an open abdominal wound and/or wound dehiscence, which increases the healing effect of NPWT.
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公开(公告)号：EP3165605B1
公开(公告)日：2019-11-06
申请号：EP15798675.3
申请日：2015-05-29
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公开(公告)号：EP2824182B1
公开(公告)日：2019-01-02
申请号：EP13758671.5
申请日：2013-03-06
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8.发明授权
公开(公告)号：EP2412377B1
公开(公告)日：2018-12-26
申请号：EP10755762.1
申请日：2010-02-05
申请人： Kracie Holdings Ltd. , National Cancer Center , National University Corporation University of Toyama
发明人： YAMAMOTO, Keiichi , OKUBO, Toshiki , YOMODA, Satoshi , ESUMI, Hiroyasu , MIYOSHI, Chika , KADOTA, Shigetoshi
IPC分类号： A61K36/28 , A61K9/14 , A61K9/19 , A61K31/365 , A61K47/36 , A61P1/18 , A61P35/00 , C07D307/33
CPC分类号： C07D307/33 , A61K9/1623 , A61K9/1688 , A61K9/19 , A61K9/2054 , A61K31/365 , A61K36/28
摘要： PROBLEM TO BE SOLVED A burdock fruit extract containing arctigenin at high content and its production method are provided, and both of which are used for treatment of pancreatic cancer. SOLUTION The burdock fruit extract containing arctigenin at high content by enzymatically converted arctiin into arctigenin with beta-glucosidase, which is an enzyme occurring endogenously in a burdock fruit, and adding ethanol, extracting, concentrating and then freeze-drying or spray drying.
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公开(公告)号：EP2824182A1
公开(公告)日：2015-01-14
申请号：EP13758671.5
申请日：2013-03-06
IPC分类号： C12N15/09 , A61K39/00 , A61K47/42 , C12N5/0783 , C12N5/10 , C12Q1/02 , G01N37/00 , G01N33/53
CPC分类号： C07K14/705 , A61K2039/5158 , C12N5/0636 , C12N2503/00 , G01N33/505 , G01N33/566 , G01N33/574 , G01N33/6869
摘要： An object of the present invention is to stimulate a T cell without using a peptide/MHC tetramer. In the present invention, the step of supplying an antigen peptide to a T cell having a T cell receptor (TCR) that can recognize the antigen peptide on cell surface to form a complex of a major histocompatibility complex (MHC) molecule on the cell surface of the T cell and the antigen peptide is used, and the T cell is stimulated through recognition by TCR of the antigen peptide as the MHC molecule-antigen peptide complex on the cell surface of the same T cell. Such a stimulating and activating method would be applicable to not only T cells, but also various cells. According to the present invention, an antigen-specific T cell can be identified without establishing any antigen-specific T cell strain, and without using such a reagent as MHC/peptide tetramer. That is, a cancer-specific T cell can be efficiently and conveniently identified.
摘要翻译： 本发明的一个目的是在不使用肽/ MHC四聚体的情况下刺激T细胞。 在本发明中，向具有可识别细胞表面的抗原肽的T细胞受体（TCR）的T细胞供给抗原肽，从而在细胞表面形成主要组织相容性复合体（MHC）分子的复合体的步骤 使用T细胞和抗原肽，通过作为同一T细胞的细胞表面的MHC分子 - 抗原肽复合物的抗原肽的TCR的识别来刺激T细胞。 这种刺激和活化方法不仅适用于T细胞，而且适用于各种细胞。 根据本发明，可以鉴定抗原特异性T细胞而不建立任何抗原特异性T细胞株，并且不使用诸如MHC /肽四聚体的试剂。 也就是说，可以有效且方便地鉴定癌症特异性T细胞。
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10.发明公开COCKTAIL ANTIBODY FOR DETERMINING HISTOLOGICAL TYPE OF CARCINOMA, DETERMINATION KIT AND DETERMINATION METHOD 有权鸡尾酒抗体DETERMINE癌症和判定处理和测定试剂盒的组织学类型
公开(公告)号：EP2423232A1
公开(公告)日：2012-02-29
申请号：EP10766905.3
申请日：2010-03-08
发明人： FUKUOKA Jyunya , TANI Yoichi
IPC分类号： C07K16/30 , G01N33/48 , G01N33/574
CPC分类号： G01N33/57423 , C07K16/18 , C07K16/40
摘要： [Problem to be solved]
The object of the present invention is to provide a cocktail antibody useful for determining the histological type of cancer, and a determination method using the same cocktail antibody is disclosed. A determination kit is also provided.
[Means to solve the problem]
The cocktail antibody is used to determine the histological type of lung carcinoma, and includes an ADC cocktail antibody that shows an antigen-antibody reaction with Napsin-A that is localized in cytoplasm of adenocarcinoma and TTF-1 that is localized in a cell nucleus of adenocarcinoma, and an SCC cocktail antibody that shows an antigen-antibody reaction with CK14 that is localized in cytoplasm of squamous cell carcinoma and p63 that is localized in a cell nucleus of squamous cell carcinoma.摘要翻译： [要解决的问题]本发明的目的是提供一种鸡尾酒抗体确定性采矿中有用的组织学类型的癌症，以及使用该抗体混合物的确定方法是游离缺失盘。 因此，一个测定试剂盒被提供。 [用于解决问题的方案鸡尾酒抗体用于确定性矿组织学类型肺癌的，并且在ADC鸡尾酒抗体包括没有与napsin A抗原 - 抗体反应展示并在腺癌和TTF-1所做的细胞质被定位 被定位在腺癌的细胞核，并与CK14并在鳞状细胞癌和p63的细胞质中并在鳞状细胞癌的细胞核定位于抗原 - 抗体反应，以SCC鸡尾酒抗体做节目。
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