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    TUMOR-INFILTRATING T-CELLS FOR USE IN THE TREATMENT OF CANCER
    1.
    发明公开
    TUMOR-INFILTRATING T-CELLS FOR USE IN THE TREATMENT OF CANCER 审中-公开

    公开(公告)号：EP4461825A2

    公开(公告)日：2024-11-13

    申请号：EP24200621.1

    申请日：2018-05-04

    申请人： Providence Health & Services - Oregon ,  Agonox, Inc.

    发明人： WEINBERG, Andrew, D. ,  MONTLER, Ryan ,  DUHEN, Thomas ,  DUHEN, Rebekka

    IPC分类号： C12Q1/6886

    摘要： Methods are disclosed for treating a subject with a tumor. These methods include administering to the subject a therapeutically effective amount of CD8+CD39+CD103+ T cells. Methods also are disclosed for isolating a nucleic acid encoding a T cell receptor (TCR) that specifically binds a tumor cell antigen. These methods include isolating CD8+CD39+CD103+ T cells from a sample from a subject with a tumor expressing the tumor cell antigen, and cloning a nucleic acid molecule encoding a TCR from the CD8+CD39+CD103+ T cells. In addition, methods are disclosed for expanding CD8+CD39+CD103+ T cells. In additional embodiments, methods are disclosed for determining if a subject with a tumor will respond to a checkpoint inhibitor. The methods include detecting the presence of CD8+CD39+CD103+ T cells in a biological sample from a subject.

    METHOD FOR IDENTIFYING SPLICING PEPTIDE
    2.
    发明公开
    METHOD FOR IDENTIFYING SPLICING PEPTIDE 审中-实审

    公开(公告)号：EP4378947A1

    公开(公告)日：2024-06-05

    申请号：EP22849383.9

    申请日：2022-07-22

    申请人： Providence Health & Services - Oregon ,  Shimadzu Corporation

    发明人： KOGUCHI, Yoshinobu ,  IWAMOTO, Noriko ,  SHIMADA, Takashi

    IPC分类号： C07K2/00

    CPC分类号： C07K2/00

    摘要： A method of identifying an unknown spliced peptide derived from a known parent peptide contained in a biological sample, the method comprising: (1) a first step involving performing mass spectrometry on the sample to obtain mass spectrometry data regarding a peptide contained in the sample; (2) a second step involving searching a primary library, which is a database of known amino acid sequences, for an amino acid sequence that matches the mass spectrometry data, to identify a parent peptide contained in the sample; (3) a third step involving creating a secondary library including a candidate group of spliced peptides obtainable from the identified parent peptide; and (4) a fourth step involving searching the secondary library for an amino acid sequence that matches the mass spectrometry data, to identify a spliced peptide contained in the sample.

    DUAL OX40 AGONIST/IL-2 CANCER THERAPY METHODS
    6.
    发明公开
    DUAL OX40 AGONIST/IL-2 CANCER THERAPY METHODS 审中-公开
    双OX40激动剂/ IL-2癌症治疗方法

    公开(公告)号：EP2819693A2

    公开(公告)日：2015-01-07

    申请号：EP12869998.0

    申请日：2012-03-02

    申请人： Providence Health & Services-Oregon D/b/a Providence Portland Medical Center

    发明人： REDMOND, William ,  WEINBERG, Andy

    IPC分类号： A61K38/20 ,  A61K39/395

    CPC分类号： A61K39/39558 ,  A61K38/177 ,  A61K38/19 ,  A61K38/20 ,  A61K38/2013 ,  A61K38/2026 ,  A61K38/2046 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/246 ,  C07K16/2875 ,  C07K2317/75 ,  A61K2300/00

    摘要： OX40 is a potent immune stimulating target. Provided herein is a method of treating cancer, which includes administering to a subject in need of treatment an OX40 agonist and a common gamma chain (yc) cytokine or an active fragment, variant, analog, or derivative thereof In certain aspects the common gamma chain (yc) cytokine is interleukin-2 (IL-2) or an active fragment, variant, analog, or derivative thereof. Combined treatment with an agonist anti-OX40 mAb and IL-2 synergized to augment tumor immunotherapy against multiple tumor types. Dual therapy was also able to restore the function of anergic tumor-reactive CD8
    + T cells.

    摘要翻译： OX40是一种有效的免疫刺激性靶点。 本文提供了治疗癌症的方法，其包括向需要治疗的受试者施用OX40激动剂和常见γ链（yc）细胞因子或其活性片段，变体，类似物或衍生物。在某些方面，共同的γ链 （yc）细胞因子是白细胞介素-2（IL-2）或其活性片段，变体，类似物或衍生物。 与激动剂抗OX40单克隆抗体和IL-2联合治疗可增强针对多种肿瘤类型的肿瘤免疫疗法。 双重疗法也能够恢复无反应性肿瘤反应性CD8 + T细胞的功能。