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公开(公告)号：EP2593111A2
公开(公告)日：2013-05-22
申请号：EP11807584.5
申请日：2011-07-15
发明人： CHAN, Pui-Kwong , MAK, May Sung
IPC分类号： A61K31/704 , A61P37/04 , A61P35/00
CPC分类号： A61K31/704 , C07H15/24 , C07J63/008 , Y02A50/409
摘要： This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, CNS, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins. It inhibits excess adhesion and inhibits cell attachment. It modulates angiogenesis. The compounds also use as mediator of cell adhesion receptor, cell circulating, cell moving and inflammatory diseases.
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2.发明公开BLOCKING THE METASTASIS OF CANCER CELLS AND THE USES OF NEW COMPOUNDS THEREOF 审中-公开癌细胞和应用锁定转移物获得的新的连接
公开(公告)号：EP2254899A1
公开(公告)日：2010-12-01
申请号：EP09721583.4
申请日：2009-02-13
发明人： CHAN, Pui-Kwong , MAK,May, Sung
CPC分类号： A61K31/7048 , A61K31/704 , C07H15/24 , Y02A50/409 , Y02A50/411 , Y02A50/486
摘要： Methods for utilizing the anticancer properties of terpenoid saponin compounds so as to modulate adhesion proteins, inhibit angiogenesis in tumors, modulate gene expression, modulate angiopoietin, enhance an immune response, provide adjuvant activities, provide vaccine activities, or inhibit the metastasis of cancer cells when contacting a subject with the compounds, wherein the cancers compose breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer, cervix cancer, esophagus cancer, testis cancer, spleen cancer, kidney cancer, lymph cancer, pancreas cancer, stomach cancer and thyroid cancer Methods, processes, compounds and compositions for antiparasitic applications which include inhibiting leishmaniases, amoebiasis, trypanosomiasis, toxoplasmosis or malaria
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3.发明公开COMPOSITION COMPRISING XANTHOCERAS SORBIFOLIA EXTRACTS, COMPOUNDS ISOLATED FROM SAME, METHODS FOR PREPARING SAME AND USES THEREOF 有权包含黄花蛇舌草提取物的组合物，由其分离的化合物，其制备方法及其用途
公开(公告)号：EP1670491A2
公开(公告)日：2006-06-21
申请号：EP04809909.7
申请日：2004-10-08
发明人： CHAN, Pui-Kwong , MAK, May, Sung , WANG, Yun
IPC分类号： A61K36/18 , A61K31/555 , A61K31/35 , A61K31/05
CPC分类号： A61K31/35 , A61K31/05 , A61K31/555 , A61K31/704 , A61K36/77
摘要： This invention provides compositions, methods and process of producing extracts from Xanthoceras sorbifolia. The extract comprises alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, saponins, tannins, acid, flavonoids and others. The composition can be used for anti-cancer, preventing cerebral aging, improving memory, improving cerebral functions and curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer’s disease, autism, brain trauma, Parkinson’s disease and other diseases caused by cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud’s syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder and treating impotence and premature ejaculation. This invention provides compounds comprise a sugar, terepene, such as Sapogenin, and a side chains at Carbon 21 and 22, such as Angeloyl groups. The compounds of the present have various pharmaceutical and therapeutic applications.
摘要翻译： 本发明提供了从文冠果提取物的组合物，方法和工艺。 提取物包括生物碱，香豆素，糖类，蛋白质，多糖，糖苷，皂苷，鞣酸，酸，类黄酮等。 该组合物可用于抗癌，预防脑老化，改善记忆力，改善脑功能和治疗遗尿，尿频，尿失禁，痴呆，智力低下和阿尔茨海默病，自闭症，脑外伤，帕金森病和其他由 脑血管功能障碍，以及治疗关节炎，风湿病，循环不良，动脉硬化，雷诺氏综合征，心绞痛，心脏疾病，冠心病，头痛，头晕，肾脏疾病以及治疗阳痿和早泄。 本发明提供了包含糖，萜烯例如皂甙元和碳21和22处的侧链的化合物，例如安琪酰基。 本发明化合物具有各种药物和治疗应用。
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4.发明公开BLOCKING THE MIGRATION OR METASTASIS OF CANCER CELLS BY AFFECTING ADHESION PROTEINS AND THE USES OF NEW COMPOUNDS THEREOF 审中-公开由责任蛋白与应安装阻止迁移或癌细胞的转移物获得的新的连接
公开(公告)号：EP2121715A1
公开(公告)日：2009-11-25
申请号：EP08725693.9
申请日：2008-02-15
发明人： CHAN, Pui-Kwong , MAK, May, Sung
IPC分类号： C07H15/256 , A01N43/08 , A61K31/04
CPC分类号： A61K31/04 , C07H15/256
摘要： This invention provides methods, processes, compounds and compositions for modulating the gene expression or secretion of adhesion proteins or their receptors to cure disease, wherein the modulating comprises positive and negative regulating; wherein comprises inhibiting cancer growth, wherein the adhesion proteins or receptors comprise fibronectin, integrins family, Myosin, vitronectin, collagen, laminin, Glycosylation cell surface proteins, polyglycans, cadherin, heparin, tenascin, CD 54, CAM, elastin and FAK; wherein the methods, processes, compounds and compositions are also for anti-angiogenesis; wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer or cervix cancer.
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公开(公告)号：EP3301105A1
公开(公告)日：2018-04-04
申请号：EP17191658.8
申请日：2011-07-15
发明人： CHAN, Pui-Kwong , MAK, May Sung
IPC分类号： C07J63/00 , A61K31/21 , A61K31/704 , A61P35/00 , C07H15/24
摘要： This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, CNS, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins. It inhibits excess adhesion and inhibits cell attachment. It modulates angiogenesis. The compounds also use as mediator of cell adhesion receptor, cell circulating, cell moving and inflammatory diseases.
摘要翻译： 本发明提供了合成用于药物用途的新型活性化合物的方法，包括癌症治疗，其中癌症包括乳腺癌，白细胞癌，肝癌，卵巢癌，膀胱癌，前列腺癌，皮肤癌，骨癌，脑癌，白血病，肺癌，结肠癌，CNS，黑素瘤，肾癌 ，宫颈癌，食道癌，睾丸癌，脾癌，肾癌，淋巴癌，胰腺癌，胃癌和甲状腺癌。 本发明是一种使用该化合物作为粘附蛋白和血管生成素的介质或抑制剂的抗粘连疗法。 它抑制过度的粘附并抑制细胞附着。 它调节血管生成。 这些化合物还可用作细胞粘附受体，细胞循环，细胞移动和炎性疾病的介质。
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公开(公告)号：EP2061798A2
公开(公告)日：2009-05-27
申请号：EP07841638.5
申请日：2007-08-30
发明人： CHAN, Pui-Kwong , MAK, May Sung
IPC分类号： C07H15/256 , A01N43/08 , A61K31/704
CPC分类号： A61K31/704 , A61K36/77 , C07J63/008
摘要： This invention provides a method for treating cancer by blocking the migration, metastasis of cancer cells, growth of cancers wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer or cervix cancer. This invention provides uses of compositions comprising a triterpenoidal saponin, triterpenoid, triterpenoidal compound or sapongenin, comprising at least two side groups selected from the group consisting of angeloyl groups, tigloyl groups and senecioyl groups, wherein the side groups are attached to carbon 21, 22 or/and 28 of triterpenoidal sapogenin, triterpenoid, triterpenoidal compound or other sapongenin backbones.
摘要翻译： 本发明提供了一种通过阻断癌细胞的迁移，转移，癌症包括乳腺癌，白血球癌，肝癌，卵巢癌，膀胱癌，前列腺癌，皮肤癌，骨癌，脑癌 癌症，白血病癌症，肺癌，结肠癌，CNS癌症，黑素瘤癌症，肾癌或宫颈癌。 本发明提供了包含三萜皂苷，三萜类化合物，三萜类化合物或皂角苷的组合物的用途，所述组合物包含至少两个选自当归酰基，双三酰基和千里光酰基的侧基，其中侧基连接到碳21,22 或/和28三萜皂苷元，三萜类化合物，三萜类化合物或其他皂角苷主链。
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公开(公告)号：EP3301105B1
公开(公告)日：2020-04-15
申请号：EP17191658.8
申请日：2011-07-15
发明人： CHAN, Pui-Kwong , MAK, May Sung
IPC分类号： C07J63/00 , A61K31/21 , A61K31/704 , A61P35/00 , C07H15/24
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公开(公告)号：EP2593111B1
公开(公告)日：2017-09-27
申请号：EP11807584.5
申请日：2011-07-15
发明人： CHAN, Pui-Kwong , MAK, May Sung
IPC分类号： A61K31/21 , C07J63/00 , A61K31/704 , A61P35/00 , C07H15/24
CPC分类号： A61K31/704 , C07H15/24 , C07J63/008 , Y02A50/409
摘要： This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, CNS, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins. It inhibits excess adhesion and inhibits cell attachment. It modulates angiogenesis. The compounds also use as mediator of cell adhesion receptor, cell circulating, cell moving and inflammatory diseases.
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9.发明授权
公开(公告)号：EP1670491B1
公开(公告)日：2015-07-29
申请号：EP04809909.7
申请日：2004-10-08
发明人： CHAN, Pui-Kwong , MAK, May, Sung , WANG, Yun
IPC分类号： A61K31/704 , A61K36/77 , A61P35/00
CPC分类号： A61K31/35 , A61K31/05 , A61K31/555 , A61K31/704 , A61K36/77
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公开(公告)号：EP2473040A1
公开(公告)日：2012-07-11
申请号：EP10800596.8
申请日：2010-07-16
发明人： CHAN, Pui-Kwong , MAK, May Sung
IPC分类号： A01N43/04
CPC分类号： A61K31/704 , A61K31/7042 , C07J63/008
摘要： This invention provides compounds, compositions, extracts, and their methods and uses for inhibiting the cancer invasion, cells invasion, cancer cell invasion,and cancer metastasis, wherein the cells comprise cancer cells, wherein the cancers comprise breast cancer, leukocytic cancer, liver cancer, ovarian cancer, bladder cancer, prostatic cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer, cervical cancer, esophageal cancer, testicular cancer, spleenic cancer, kidney cancer, lymphhatic cancer, pancreatic cancer, stomach cancer and thyroid cancer.
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