公开(公告)号：EP1891233A4

公开(公告)日：2010-03-24

申请号：EP06758673

申请日：2006-04-24

申请人： YEDA RES & DEV ,  TEVA PHARMA ,  RAPPAPORT FACULTY OF MEDICINE

发明人： LANCET DORON ,  BECKMANN JACQUES ,  AVIDAN NILI ,  BEN-ASHER EDNA ,  GOLDSTAUB DAN ,  HAYARDENY LIAT ,  GROSSMAN IRIS ,  MILLER ARIEL ,  SINGER CLARA

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6827 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172 ,  Y10T436/143333

公开(公告)号：EP1891233A2

公开(公告)日：2008-02-27

申请号：EP06758673.5

申请日：2006-04-24

申请人： YEDA RESEARCH AND DEVELOPMENT CO., LTD. ,  Teva Pharmaceutical Industries, Inc. ,  Rappaport Faculty of Medicine and Research Institute

发明人： LANCET, Doron ,  BECKMANN, Jacques ,  AVIDAN, Nili ,  BEN-ASHER, Edna ,  GOLDSTAUB, Dan ,  HAYARDENY, Liat ,  GROSSMAN, Iris ,  MILLER, Ariel ,  SINGER, Clara

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6827 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172 ,  Y10T436/143333

摘要： The present invention is directed to methods and kits based, at least in part, on the identification of allele-specific responsiveness or non-responsiveness to glatiramer acetate for the treatment of immune disorders, such as relapsing-remitting multiple sclerosis. The allele-specific responsiveness or non-responsiveness is based on polymorphisms in the following genes, CTSS, MBP, TCRB, CD95, CD86, IL-1R1, CD80, SCYA5, MMP9, MOG, SPPl and IL-12RB2.