公开(公告)号：EP4059962A1

公开(公告)日：2022-09-21

申请号：EP20882932.5

申请日：2020-10-30

申请人： Sanyou Biopharmaceuticals Co., Ltd.

发明人： KONG, Chao ,  LANG, Guojun ,  WU, Qi ,  LIU, Chanjuan ,  YAN, Run ,  YAN, Xintian ,  TAN, Lunmei

IPC分类号： C07K16/28 ,  C12N15/13 ,  C12N15/63 ,  C12N5/10 ,  A61K39/395 ,  A61P35/00

摘要： The present application provides an isolated PD-L1 binding molecule, specifically, an isolated PD-L1 single-domain antibody or an antigen-binding fragment thereof. The present invention also provides a nucleic acid encoding the isolated PD-L1 binding molecule, an expression vector or host cell comprising the nucleic acid, and a pharmaceutical composition or kit comprising the PD-L1 binding molecule.

公开(公告)号：EP3978532A1

公开(公告)日：2022-04-06

申请号：EP20815629.9

申请日：2020-05-21

申请人： Sanyou Biopharmaceuticals Co., Ltd.

发明人： TAN, Yongcong ,  LANG, Guojun ,  KONG, Chao ,  LIU, Chanjuan ,  DENG, Min ,  WU, Qi ,  ZHANG, Jing ,  ZHANG, Wenhai ,  FAN, Baoguo

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00

摘要： Disclosed is a novel CLDN18.2 binding molecule. Also disclosed are a nucleic acid molecule encoding the CLDN18.2 binding molecule, an expression vector and a host cell for expressing the CLDN18.2 binding molecule. Further disclosed are a method for producing the CLDN18.2 binding molecule and use thereof.

公开(公告)号：EP4421092A1

公开(公告)日：2024-08-28

申请号：EP22882219.3

申请日：2022-03-21

申请人： Dragonboat Biopharmaceutical (Shanghai) Co., Ltd. ,  Sanyou Biopharmaceuticals Co., Ltd.

发明人： HUANG, Yingfeng ,  LANG, Guojun ,  TAN, Yongcong ,  SHAO, Zhe ,  ZHANG, Ruixia ,  YAN, Run ,  WANG, Tao ,  XU, Junyan ,  HU, Yuhao ,  ZHANG, Wenhai

IPC分类号： C07K16/28 ,  C07K16/46 ,  C12N5/10 ,  C12N15/85 ,  C12P19/34 ,  A61P35/00 ,  A61K39/395

CPC分类号： A61K39/395 ,  A61K47/68 ,  A61P35/00 ,  C07K16/00 ,  C07K16/28 ,  C07K16/46 ,  C12N5/10 ,  C12N15/70 ,  C12N15/74 ,  C12N15/85 ,  C12P19/34 ,  C12R2001/1920210501

摘要： The present invention belongs to the field of biomedicine. Specifically, the present invention relates to an anti-CD47/anti-CLDN18.2 bispecific antibody and the use thereof.

公开(公告)号：EP4372004A1

公开(公告)日：2024-05-22

申请号：EP22841402.5

申请日：2022-07-13

申请人： Sanyou Biopharmaceuticals Co., Ltd.

发明人： YAN, Xintian ,  LANG, Guojun ,  TAN, Yongcong ,  LIU, Chanjuan ,  KONG, Chao ,  YAN, Run ,  LIU, Yaru ,  YAO, Tianen

IPC分类号： C07K16/18 ,  C12N15/13 ,  C12N15/63 ,  C12N5/10 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  A61P35/00 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/46 ,  C12N5/10 ,  C12N15/85 ,  G01N33/574 ,  G01N33/68 ,  C07K16/18 ,  C12N15/63

摘要： The present invention relates to specific CLDN18.2 binding molecules, and an immunoconjugate and a composition containing the CLDN18.2 binding molecules. The present invention further relates to a nucleic acid encoding the CLDN18.2 binding molecules, a host cell containing same, and a method for preparing the CLDN18.2 binding molecules. Furthermore, the present invention relates to the therapeutic and diagnostic use of the CLDN18.2 binding molecules. In particular, the present invention relates to the combined treatment of the CLDN18.2 binding molecules with other therapies, such as a therapeutic method or a therapeutic agent.

公开(公告)号：EP4253411A1

公开(公告)日：2023-10-04

申请号：EP21896926.9

申请日：2021-11-23

申请人： Sanyou Biopharmaceuticals Co., Ltd.

发明人： TAN, Yongcong ,  LANG, Guojun ,  LIU, Chanjuan ,  YAN, Xintian

IPC分类号： C07K16/18 ,  C12N15/13 ,  G01N33/574 ,  A61K39/395 ,  A61P35/00

摘要： Provided are a molecule specifically binding to CLDN18.2, the molecule comprising an immunoglobulin single variable domain, a nucleic acid molecule encoding the molecule specifically binding to CLDN18.2, and an expression vector and a host cell for expressing the molecule specifically binding to CLDN18.2; further provided are a method for producing the molecule specifically binding to CLDN18.2 and use thereof for treating or preventing conditions associated with CLDN18.2.