利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.016 秒)

    CROSS-PROTECTIVE PROTECTION AGAINST INFLUENZA VIRAL INFECTION
    1.
    发明公开
    CROSS-PROTECTIVE PROTECTION AGAINST INFLUENZA VIRAL INFECTION 审中-公开

    公开(公告)号：EP3450454A1

    公开(公告)日：2019-03-06

    申请号：EP18199721.4

    申请日：2011-07-22

    申请人： Schrader, John W.

    发明人： Schrader, John W.

    IPC分类号： C07K16/10 ,  A61K39/145 ,  A61K39/295 ,  A61P37/04 ,  C12P21/08 ,  C12Q1/70 ,  A61P31/16 ,  A61K39/00 ,  A61K39/12

    摘要： The present disclosure provides a method of inducing a cross-protective immune response in a subject against a pathogen, such as influenza, comprising administering a first unique pathogen antigen to the subject; and administering a second unique pathogen antigen 3-52 weeks after a); wherein the second unique pathogen antigen and the first unique pathogen antigen are immunologically distinct but share conserved sites that are not normally immunogenic for antibodies. Also disclosed herein are assays for detecting cross-protective antibodies, methods of generating novel cross-protective antibodies. Further provided are novel antibodies against influenza.

    CROSS-PROTECTIVE PATHOGEN PROTECTION, METHODS AND COMPOSITIONS THEREOF
    4.
    发明公开
    CROSS-PROTECTIVE PATHOGEN PROTECTION, METHODS AND COMPOSITIONS THEREOF 审中-公开
    保护，禁止交叉反应的病原体及方法及其组合物

    公开(公告)号：EP2596017A4

    公开(公告)日：2014-03-19

    申请号：EP11809104

    申请日：2011-07-22

    申请人： SCHRADER JOHN W

    发明人： SCHRADER JOHN W

    IPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/145 ,  A61K39/295 ,  A61P31/16 ,  A61P37/04 ,  C12P21/08 ,  C12Q1/70

    CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/545 ,  A61K2039/575 ,  C07K16/1018 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C12N2760/16134

    摘要： The present disclosure provides a method of inducing a cross-protective immune response in a subject against a pathogen, such as influenza, comprising administering a first unique pathogen antigen to the subject; and administering a second unique pathogen antigen 3-52 weeks after a); wherein the second unique pathogen antigen and the first unique pathogen antigen are immunologically distinct but share conserved sites that are not normally immunogenic for antibodies. Also disclosed herein are assays for detecting cross-protective antibodies, methods of generating novel cross-protective antibodies. Further provided are novel antibodies against influenza.

    摘要翻译： 本发明提供了诱导针对病原体,:诸如流感的受试者的交叉保护性免疫应答，包括给予第一唯一病原体抗原的受试者的方法; 和施用第二独特病原体抗原后3-52周）; worin第二唯一致病抗原和第一独特的病原体抗原免疫学上不同，但共同保守位点没有不正常的免疫原性的抗体。 所以光盘中游离缺失是用于检测交叉保护性抗体，产生新的交叉保护性抗体的方法测定。 进一步提供的是针对流感的新抗体。