公开(公告)号：EP3511339A1

公开(公告)日：2019-07-17

申请号：EP18213025.2

申请日：2013-02-19

申请人： Swedish Orphan Biovitrum AB (Publ)

发明人： BERGHARD, Charlotta ,  BERGLUND, Magnus ,  STRÖMBERG, Patrik ,  LINDBORG, Malin ,  GUNNERIUSSON, Elin ,  FELDWISCH, Joachim

IPC分类号： C07K14/47 ,  C07K14/315 ,  C07K14/195 ,  A61K38/00 ,  A61K38/16 ,  C07K14/00 ,  A61K47/64 ,  A61K47/68

摘要： The present invention relates to C5 binding polypeptides, comprising a C5 binding motif, BM , which motif consists of an amino acid sequence selected from
i) EX 2 X 3 X 4 A X 6 X 7 EID X 11 LPNL X 16 X 17 X 18 QW X 21 AFIX 25 X 26 LX 28 D, and
ii) an amino acid sequence which has at least 86 % identity to the sequence defined in i), wherein the polypeptide binds to C5. The present invention moreover relates to C5 binding polypeptides for use in therapy, such as for use in treatment of a C5 related condition, and to methods of treatments.

公开(公告)号：EP2211948B1

公开(公告)日：2018-12-12

申请号：EP08852233.9

申请日：2008-11-21

申请人： Swedish Orphan Biovitrum AB (publ)

发明人： FRANSSON, Jonas ,  HJERTMAN, Birger

IPC分类号： A61M5/28 ,  A61M5/19 ,  A61M5/315

CPC分类号： A61M5/284 ,  A61M5/31501 ,  A61M5/31596 ,  A61M2005/1787 ,  A61M2005/3132

摘要： A device for the serial ejection of at least two fluid components comprises a spacer (19) providing at least two states, i) a first state allowing a front piston (7) to be displaced forwards by action on a rear piston (17) while a fluid volume is retained in a rear chamber (5) and ii) a second state allowing the rear chamber to volumetrically shrink while fluid is transferred past (or through) the front piston thereby enabling the use of a liquid, initially provided in only the rear chamber, for the dual purposes of mixing and rinsing.

公开(公告)号：EP3355912A1

公开(公告)日：2018-08-08

申请号：EP16778742.3

申请日：2016-09-30

申请人： Swedish Orphan Biovitrum AB (Publ)

发明人： NORDLING, Erik ,  STRÖMBERG, Patrik ,  SVENSSON GELIUS, Stefan

IPC分类号： A61K38/46 ,  C12N9/16

CPC分类号： A61K38/46 ,  A61K38/00 ,  A61P3/00 ,  C12N9/16 ,  C12Y301/06013

摘要： Disclosed herein are a modified iduronate 2-sulfatase, a composition comprising a modified iduronate 2-sulfatase, as well as methods for preparing a modified iduronate 2-sulfatase and therapeutic use of such a iduronate 2-sulfatase. In particular, the present disclosure relates to a modified iduronate 2-sulfatase sulfatase comprising substantially no epitopes for glycan recognition receptors, wherein said iduronate 2-sulfatase has a catalytic activity of at least 50% of that of unmodified iduronate 2-sulfatase in vitro.

公开(公告)号：EP3038633A1

公开(公告)日：2016-07-06

申请号：EP14765883.5

申请日：2014-08-28

申请人： Swedish Orphan Biovitrum AB (Publ)

发明人： NILSSON, Joakim ,  NORDLING, Erik ,  STRÖMBERG, Patrik

IPC分类号： A61K38/00 ,  C07K14/47

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/315

摘要： The invention relates to a polypeptide capable of binding human complement component 5 (C5), said polypeptide comprising the amino acid sequence [BM]-[L2]-QSX42X43LLX46EAKKLX52X53X54Q wherein [BM] is a C5 bindingmotif; [L2] is an interconnecting loop; X42 is selected from A and S; X43 is selected from N and E; X46 is selected from A, S and C; X52 is selected from E, N and S; X53 is selected from D, E and S, provided that X53 is not D when X52 is N; and X54 is selected from A and S.

摘要翻译： 本发明涉及能够结合人补体成分5（C5）的多肽，所述多肽包含氨基酸序列[BM] - [L2] -QSX42X43LLX46EAKKLX52X53X54Q，其中[BM]为C5结合基团; [L2]是互连环路; X42选自A和S; X43选自N和E; X46选自A，S和C; X52选自E，N和S; X53选自D，E和S，条件是当X52为N时，X53不为D; X54选自A和S.

公开(公告)号：EP1827483B1

公开(公告)日：2014-07-02

申请号：EP05853972.7

申请日：2005-12-12

申请人： Swedish Orphan Biovitrum AB (publ)

发明人： TREUHEIT, Michael, J. ,  DHARMAVARAM, Vasumathi ,  PURTELL, Judith ,  ROY, Suzanne, E.

IPC分类号： A61K38/18 ,  A61K47/18 ,  A61K47/26

CPC分类号： A61K9/19 ,  A61K38/1825 ,  A61K47/183 ,  A61K47/26 ,  C07K14/50

公开(公告)号：EP2672985A1

公开(公告)日：2013-12-18

申请号：EP12744410.7

申请日：2012-02-09

申请人： Swedish Orphan Biovitrum AB (Publ)

发明人： FRANSSON, Jonas ,  FLORIN-ROBERTSSON, Ebba

IPC分类号： A61K38/20 ,  A61K9/08 ,  A61P29/00

CPC分类号： A61K38/2006 ,  A61K9/0019 ,  A61K9/10 ,  A61K38/00 ,  A61K38/1793 ,  A61K47/02 ,  A61K47/183 ,  A61K47/26 ,  C07K14/545 ,  C07K14/7155

摘要： The present invention relates to pharmaceutical compositions comprising anakinra as an active compound in the absence of sodium citrate. The said pharmaceutical compositions are useful for the treatment of IL-1 mediated disorders and for decreasing nociceptive pain during such treatment.

公开(公告)号：EP1334981B1

公开(公告)日：2011-01-26

申请号：EP02028624.1

申请日：1995-10-12

申请人： Swedish Orphan Biovitrum AB (publ)

发明人： Hsu, Eric W. ,  Kenney, William C. ,  Tressel, Tim

IPC分类号： C07K14/50

CPC分类号： C07K14/50

公开(公告)号：EP4121091A1

公开(公告)日：2023-01-25

申请号：EP21711287.9

申请日：2021-03-16

申请人： Swedish Orphan Biovitrum AB (publ)

发明人： DE MIN, Cristina

IPC分类号： A61K38/20 ,  A61K38/17 ,  A61P31/14 ,  A61K45/06 ,  A61K31/573

公开(公告)号：EP4100035A1

公开(公告)日：2022-12-14

申请号：EP21703436.2

申请日：2021-02-04

申请人： Swedish Orphan Biovitrum AB (publ)

发明人： HULEDAL, Gunilla ,  KAISER, Christina ,  WINDING, Bent

IPC分类号： A61K38/00 ,  A61P35/00 ,  C07H5/02 ,  A61K38/20 ,  A61K38/17 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61K31/555 ,  A61K31/7068 ,  A61K33/243 ,  A61K45/06

公开(公告)号：EP3288536A1

公开(公告)日：2018-03-07

申请号：EP16722558.0

申请日：2016-04-27

申请人： Swedish Orphan Biovitrum AB (publ)

发明人： FLORIN-ROBERTSSON, Ebba ,  FRANSSON, Jonas ,  MOORE, Barry D.

IPC分类号： A61K9/00 ,  A61K38/20 ,  A61P27/02

CPC分类号： A61K38/2006 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61P27/02 ,  A61P27/04 ,  A61P27/14 ,  A61K2300/00

摘要： The present invention relates to compositions comprising anakinra, buffer, and optionally at least one osmolyte and optionally further excipients. Further, the present invention relates to use of said compositions for treatment of for example ophthalmic disorders.