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公开(公告)号：EP1309556A1
公开(公告)日：2003-05-14
申请号：EP01974982.9
申请日：2001-08-15
发明人： LEMMENS, Jacobus, Maria , PETERS, Theodorus, Hendricus, Antonius , BENNEKER, Franciscus, Bernardus, Gemma , PICHA, Frantisek
IPC分类号： C07D211/90 , A61K31/44 , A61P9/10
CPC分类号： A61K31/4422
摘要： Amlodipine fumarate salt compounds are useful as calcium channel blockers and in treating or preventing angina or hypertension. The fumarate salts avoid the formation of certain potential impurities that have been found to be associated with amlodipine maleate.
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公开(公告)号：EP1309555A1
公开(公告)日：2003-05-14
申请号：EP01972796.5
申请日：2001-08-15
IPC分类号： C07D211/90 , A61K31/44 , A61P9/10
CPC分类号： A61K31/4422 , C07D211/90
摘要： A process for making amlodipine maleate comprises reacting amlodipine or an acid addition salt thereof with maleic acid under an acidic environment to form an amlodipine maleate product. The process allows for the formation of amlodipine maleate substantially free from amlodipine aspartate.
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公开(公告)号：EP1309317A1
公开(公告)日：2003-05-14
申请号：EP01970353.7
申请日：2001-08-15
CPC分类号： A61K9/2054 , A61K9/2009 , A61K9/485 , A61K9/4866 , A61K31/4422
摘要： A new pharmaceutical composition (A) contains an effective amount of amlodipine maleate (I) and one or more auxiliaries (II), and has a pH of 5.5-7.0 (preferably 6.0-7.0).
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公开(公告)号：EP1309558A1
公开(公告)日：2003-05-14
申请号：EP01974985.2
申请日：2001-08-15
发明人： LEMMENS, Jacobus, Maria , PETERS, Theodorus, Hendricus, Antonius , BENNEKER, Franciscus, Bernardus, Gemma
IPC分类号： C07D211/90 , A61K31/4418 , A61P9/12
CPC分类号： C07D213/90
摘要： An amlodipine derivative having the following formula is useful, either alone or in combination with amlodipine, as a pharmaceutical in treating angina and hypertension.
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公开(公告)号：EP1309557A1
公开(公告)日：2003-05-14
申请号：EP01974984.5
申请日：2001-08-15
IPC分类号： C07D211/90 , A61K31/44 , A61P9/10
CPC分类号： C07D211/90
摘要： Amlodipine hemimaleate is useful as a calcium channel blocker and can be used to treat or prevent angina or hypertension.
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公开(公告)号：EP1309554A1
公开(公告)日：2003-05-14
申请号：EP01972794.0
申请日：2001-08-15
发明人： LEMMENS, Jacobus, Maria , PETERS, Theodorus, Hendricus, Antonius , BENNEKER, Franciscus, Bernardus, Gemma
IPC分类号： C07D211/90 , A61K31/44 , A61P9/10
CPC分类号： C07D211/90 , A61K31/4422
摘要： A derivative of amlodipine having the following formula is useful as pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension.
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