公开(公告)号：EP3875481A1

公开(公告)日：2021-09-08

申请号：EP21158309.1

申请日：2015-11-13

申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services ,  The United States Government, as represented by The Secretary of The Army ,  Humabs Biomed SA ,  Institute for Research in Biomedicine

发明人： CORTI, Davide ,  LANZAVECCHIA, Antonio ,  TREFRY, John ,  SULLIVAN, Nancy ,  MULANGU, Sabue ,  GRAHAM, Barney ,  MUYEMBE-TAMFUN, Jean-Jacques ,  LEDGERWOOD, Julie ,  STANLEY, Daphne

IPC分类号： C07K16/10

摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.

公开(公告)号：EP0366066A1

公开(公告)日：1990-05-02

申请号：EP89119720.4

申请日：1989-10-24

申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  THE UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE ARMY

发明人： Tidwell, Richard R. ,  Geratz, J. Dieter ,  Ohemeng, Kwasi A. ,  Hall, James Edwin ,  Kyle, Dennis E. ,  Grogl, Max

IPC分类号： C07C257/18 ,  C07C323/32 ,  C07D233/14 ,  C07D233/16 ,  A61K31/155 ,  A61K31/415

CPC分类号： C07D239/22 ,  C07C257/18 ,  C07D239/24

摘要： New pentamidine analogue compounds and compositions containing the new analogues are disclosed. Methods for the treatment of, and prophylaxis against, Pneumocystis carinii pneumonia, and methods for treating leishmaniasis, giardiasis, and malaria using the new analogues are also disclosed.

摘要翻译： 新喷他脒模拟化合物和包含新类似物的组合物游离缺失盘。 因此方法的治疗，以及对，卡氏肺囊虫肺炎的预防，与方法治疗利什曼病，贾第虫病，疟疾和使用新的类似物是游离缺失盘。

公开(公告)号：EP0366066B1

公开(公告)日：1995-03-01

申请号：EP89119720.4

申请日：1989-10-24

申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  THE UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE ARMY

发明人： Tidwell, Richard R. ,  Geratz, J. Dieter ,  Ohemeng, Kwasi A. ,  Hall, James Edwin ,  Kyle, Dennis E. ,  Grogl, Max

IPC分类号： C07C257/18 ,  C07C323/32 ,  C07D233/14 ,  C07D233/16 ,  A61K31/155 ,  A61K31/415

CPC分类号： C07D239/22 ,  C07C257/18 ,  C07D239/24

公开(公告)号：EP3472127A1

公开(公告)日：2019-04-24

申请号：EP17733313.5

申请日：2017-06-16

申请人： The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. ,  The United States Government, as represented by The Secretary of The Army

发明人： KHAVRUTSKII, Ilja ,  WALLQVIST, Anders

IPC分类号： C07C215/08 ,  A61P25/00

公开(公告)号：EP2742055B1

公开(公告)日：2019-10-16

申请号：EP12845143.2

申请日：2012-08-10

申请人： Drexel University ,  THE UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE ARMY

发明人： PALMESE, Giuseppe R. ,  LA SCALA, John Joseph ,  SADLER, Joshua Matthew ,  LAM, Anh-Phuong Thy

IPC分类号： C07D493/04 ,  C08F124/00 ,  C08F224/00 ,  C08F122/20 ,  C08F220/32 ,  C08F222/20 ,  C08F236/14

公开(公告)号：EP3218397A1

公开(公告)日：2017-09-20

申请号：EP15797815.6

申请日：2015-11-13

申请人： The United States Of America, As Represented By The Secretary, Department Of Health And Human Services ,  Corti, Davide ,  The United States Government, as represented by The Secretary of The Army ,  Humabs Biomed S.A. ,  Institute for Research in Biomedicine

发明人： CORTI, Davide ,  LANZAVECCHIA, Antonio ,  TREFRY, John ,  SULLIVAN, Nancy ,  MULANGU, Sabue ,  GRAHAM, Barncy ,  MUYEMBE-TAMFUN, Jean-Jacques ,  LEDGERWOOD, Julie ,  STANLEY, Daphne

IPC分类号： C07K16/10

CPC分类号： C07K16/10 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N2333/08

摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.

摘要翻译： 公开了特异性结合埃博拉病毒糖蛋白的中和抗体和抗原结合片段。 还提供了编码这些抗体的核酸，载体和宿主细胞。 公开了使用抗体和抗原结合片段检测埃博拉病毒的方法。 例如，抗体，抗原结合片段，核酸和载体可用于预防和/或治疗受试者中的埃博拉病毒感染。

公开(公告)号：EP2358301B1

公开(公告)日：2019-07-17

申请号：EP09829422.6

申请日：2009-08-05

申请人： The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. ,  The United States Government, as represented by The Secretary of The Army ,  The United States Government as represented by The National Institutes of Health

发明人： JACKSON, Wesley, M. ,  NESTI, Leon, J. ,  TUAN, Rocky, S.

IPC分类号： A61F2/02 ,  A61L27/18 ,  A61L27/34 ,  A61L27/38 ,  A61L27/56 ,  A61L27/58 ,  C12N5/0775

公开(公告)号：EP0817619A1

公开(公告)日：1998-01-14

申请号：EP96944247.0

申请日：1996-11-18

申请人： THE UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE ARMY

发明人： JEYANTHI, Ramasubbu ,  VAN HAMONT, John, F. ,  FRIDEN, Phil ,  REID, Robert, H. ,  ROBERTS, F., Donald ,  McQUEEN, Charles, E. ,  SETTERSTROM, Jean, A.

IPC分类号： A61K9 ,  A61K38 ,  A61K47

CPC分类号： A61K38/1709 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1641 ,  A61K9/1647 ,  Y02A50/473

摘要： Novel burst-free, sustained release biocompatible and biodegradable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.