公开(公告)号：EP3248530B1

公开(公告)日：2020-11-04

申请号：EP16020288.3

申请日：2016-07-29

申请人： The First Affiliated Hospital of Guangzhou Medical University ,  Hangzhou Hawk Optical Electronic Instruments Co., Ltd. ,  Guangzhou Minitech Medical Technology Co., Ltd.

发明人： ZENG, Guohua ,  BAO, Guohua ,  LU, Xinrong ,  HUA, Lifang ,  MA, Jianqiang

IPC分类号： A61B1/00

公开(公告)号：EP3248530A1

公开(公告)日：2017-11-29

申请号：EP16020288.3

申请日：2016-07-29

申请人： The First Affiliated Hospital of Guangzhou Medical University ,  Hangzhou Hawk Photoelectric Instruments Co., Ltd. ,  Guangzhou Minitech Trade Company Ltd.

发明人： ZENG, Guohua ,  BAO, Guohua ,  LU, Xinrong ,  HUA, Lifang ,  MA, Jianqiang

IPC分类号： A61B1/00

摘要： The invention discloses a surgical instrument and a method of using the same, more particularly a percutaneous puncture and dilation visible irrigation-suction system and a method of using the same, comprising a main tube, which is contiguous with the sheath tube and has an end for an endoscope insertion. The sheath tube comprises an inner sheath and an outer sheath joined together in a sleeve type. There is a space between inner and outer sheath. The inner sheath is connected to main tube, together building a channel via which the endoscope is inserted and withdrawn. The sheath tube is connected to main tube after completing puncture and dilation, then endoscope system is introduced for observation and operation. The present invention provides a percutaneous puncture and dilation visible irrigation-suction system and a method of using the same, with a continuous controllable visible negative pressure aspirator, achieving high irrigation and powerful suction efficiency, as well as clear endoscopic view. This invention solves existing instrumental and technical problems, including low irrigation pressure, obscured visibility, small irrigation and suction channel, complicated procedures, and poor versatility due to different instruments required by different kinds of procedures.

摘要翻译： 本发明公开了一种外科手术器械及其使用方法，更具体地涉及一种经皮穿刺扩张可见冲洗吸引系统及其使用方法，包括主管，与主管邻接，主管端部 用于内窥镜插入。 护套管包括以套筒类型连接在一起的内护套和外护套。 内外鞘之间有一个空间。 内护套连接到主管，一起构建内窥镜插入和抽出的通道。 穿刺扩张完成后将套管与主管连接，然后引入内窥镜系统进行观察和手术。 本发明提供了一种经皮穿刺和扩张的可见吸入 - 抽吸系统及其使用方法，其具有连续可控的可见负压吸引器，实现了高冲洗和强大的抽吸效率，以及清晰的内窥镜视图。 本发明解决了现有的仪器和技术问题，包括由于不同程序所需的不同仪器而造成的低灌溉压力，模糊的可见度，小的灌溉和吸入通道，复杂的程序以及差的通用性。

公开(公告)号：EP3248530A3

公开(公告)日：2018-08-01

申请号：EP16020288.3

申请日：2016-07-29

申请人： The First Affiliated Hospital of Guangzhou Medical University ,  Hangzhou Hawk Photoelectric Instruments Co., Ltd. ,  Guangzhou Minitech Trade Company Ltd.

发明人： ZENG, Guohua ,  BAO, Guohua ,  LU, Xinrong ,  HUA, Lifang ,  MA, Jianqiang

IPC分类号： A61B1/00

CPC分类号： A61B1/015 ,  A61B1/00 ,  A61B1/00119 ,  A61B1/00135 ,  A61B1/00154 ,  A61B1/0661 ,  A61B1/12 ,  A61B1/3132 ,  A61B17/34 ,  A61B17/3421 ,  A61B2017/3445 ,  A61B2017/3447 ,  A61M1/0058 ,  A61M1/008

摘要： The invention discloses a surgical instrument and a method of using the same, more particularly a percutaneous puncture and dilation visible irrigation-suction system and a method of using the same, comprising a main tube, which is contiguous with the sheath tube and has an end for an endoscope insertion. The sheath tube comprises an inner sheath and an outer sheath joined together in a sleeve type. There is a space between inner and outer sheath. The inner sheath is connected to main tube, together building a channel via which the endoscope is inserted and withdrawn. The sheath tube is connected to main tube after completing puncture and dilation, then endoscope system is introduced for observation and operation. The present invention provides a percutaneous puncture and dilation visible irrigation-suction system and a method of using the same, with a continuous controllable visible negative pressure aspirator, achieving high irrigation and powerful suction efficiency, as well as clear endoscopic view. This invention solves existing instrumental and technical problems, including low irrigation pressure, obscured visibility, small irrigation and suction channel, complicated procedures, and poor versatility due to different instruments required by different kinds of procedures.

公开(公告)号：EP3144003A1

公开(公告)日：2017-03-22

申请号：EP15793101.5

申请日：2015-04-08

申请人： The First Affiliated Hospital of Guangzhou Medical University ,  Guangzhou Institute of Respiratory Disease ,  State Key Laboratory of Respiratory Disease

发明人： LAI, Kefang ,  ZHONG, Shan ,  GAN, Zhenyong ,  LIU, Xiaodong ,  NIE, Yichu ,  ZHONG, Nanshan

IPC分类号： A61K31/715 ,  A61P11/14 ,  A61P11/00 ,  A61P29/00

CPC分类号： A61K31/715 ,  A23L5/00 ,  A23L29/30 ,  A23L33/125 ,  A23P10/00 ,  A23V2002/00 ,  A61K36/79 ,  A61K2236/15 ,  A61K2236/33

摘要： An application of Fructus schisandrae total polysaccharides in the preparation of medicine or nutraceuticals used for treating coughing, and a pharmaceutical or nutraceutical composition containing Fructus schisandrae total polysaccharides. Experiments demonstrate that Fructus schisandrae total polysaccharides can be used for preparing antitussive and cough relief medicine and medicine to eliminate inflammation of the airways.

摘要翻译： 五味子总多糖的医药或用于治疗咳嗽营养制品的制备中的应用，以及含有五味子总多糖的药物或营养组合物。 实验证明确实五味子总多糖可用于制备和镇咳止咳药和药物，以消除气道炎症。

公开(公告)号：EP3213758B1

公开(公告)日：2019-08-28

申请号：EP15854513.7

申请日：2015-09-21

申请人： The First Affiliated Hospital of Guangzhou Medical University ,  Guangzhou Institute of Respiratory Disease

发明人： LAI, Kefang ,  LIU, Xiaodong ,  ZHONG, Bonian ,  ZHONG, Shan ,  HUANG, Chuqin

IPC分类号： A61K36/264 ,  A61K31/36 ,  C07D493/04 ,  A61P11/14

公开(公告)号：EP3213758A1

公开(公告)日：2017-09-06

申请号：EP15854513.7

申请日：2015-09-21

申请人： The First Affiliated Hospital of Guangzhou Medical University ,  Guangzhou Institute of Respiratory Disease

发明人： LAI, Kefang ,  LIU, Xiaodong ,  ZHONG, Bonian ,  ZHONG, Shan ,  HUANG, Chuqin

IPC分类号： A61K36/264 ,  A61K31/36 ,  C07D493/04 ,  A61P11/14

CPC分类号： C07D493/04 ,  A61K31/36 ,  A61K36/264 ,  A61K2236/13 ,  A61K2236/33 ,  A61K2236/37 ,  A61K2236/39 ,  Y02P20/544

摘要： Provided are a method for extracting high-purity asarinin and use thereof, which belongs to the field of natural medicines. The method comprises: putting coarse asarum powder in a supercritical CO 2 extraction device; under the conditions that an extraction kettle has a pressure of 30-40 Mpa and a temperature of 45-70°C, separating kettles I and II have a pressure of 5-10 Mpa and a temperature of 30-50°C and the flow rate of CO 2 is 35-60 L/h, extracting for 60 to 240 minutes to obtain asarum total volatile oil; standing the asarum total volatile oil for 24-72 hours at a low temperature, and filtering under reduced pressure to obtain an asarinin coarse product; re-crystallizing the asarinin coarse product in absolute ethanol twice to obtain an asarinin pure product. In addition, it is found for the first time that asarinin has a good cough-relieving activity and thus can be used in preparing medicines for treating various types of coughs. Firstly disclosed is a brand-new preparation process for extracting asarinin by a supercritical CO 2 extraction method, and this method has the advantages of simple process, no solvent residue, high product purity, etc.

摘要翻译： 提供了一种提取高纯度asarinin的方法及其用途，属于天然药物领域。 该方法包括：将粗细化粉放入超临界CO2萃取装置中; 在提取釜压力为30-40Mpa，温度为45-70℃的条件下，分离釜I和II的压力为5-10MPa，温度为30-50℃，流速 二氧化碳的速率为35-60 L / h，提取60至240分钟以获得细辛总挥发油; 将细辛总挥发油在低温下放置24-72小时，并在减压下过滤以获得asarinin粗产物; 将无水乙醇中的沙雷菌素粗产物重结晶两次以获得沙雷菌素纯产物。 此外，首次发现沙林毒素具有良好的止咳活性，因此可用于制备治疗各种类型咳嗽的药物。 首次公开了一种采用超临界CO2萃取法提取沙雷毒素的全新制备工艺，该方法工艺简单，无溶剂残留，产品纯度高等优点。