公开(公告)号：EP3451973A1

公开(公告)日：2019-03-13

申请号：EP17793543.4

申请日：2017-05-08

申请人： Transmural Systems LLC ,  The United States of America, as represented by The Secretary, Department of Health and Human Services (National Institutes of Health)

发明人： RAFIEE, Nasser ,  MACDONALD, Stuart ,  RAFIEE, Koosha ,  BUSOLD, Rany ,  LEDERMAN, Robert J. ,  ROGERS, Toby

IPC分类号： A61F2/24 ,  A61M25/01 ,  A61M25/098 ,  A61B17/32

公开(公告)号：EP1812474A2

公开(公告)日：2007-08-01

申请号：EP05815961.7

申请日：2005-10-14

申请人： The United States of America as represented by The Secretary, Department of Health and Human Services National Institutes of Health

发明人： REMALEY, Alan T. ,  DEMOSKY, Stephen J. ,  STONIK, John A. ,  AMAR, Marcele J, A. ,  NEUFELD, Edward B. ,  BREWER, H, Bryan ,  THOMAS, Fairwell

IPC分类号： C07K14/775 ,  A61K38/16 ,  G01N33/68 ,  A61P9/10

CPC分类号： C07K14/775 ,  A61K38/00

摘要： Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCAl-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.

公开(公告)号：EP1825006A2

公开(公告)日：2007-08-29

申请号：EP05852239.2

申请日：2005-11-23

申请人： The Texas A&M University System ,  The United States of America as represented by The Secretary, Department of Health and Human Services National Institutes of Health

发明人： KISH, Laszlo ,  DOBOZI-KING, Maria ,  YOUNG, Ryland ,  CHENG, Mosong ,  BIARD, James, R. ,  BEZRUKOV, Sergey

IPC分类号： C12Q1/70 ,  G01N33/554

CPC分类号： B82Y30/00 ,  B01L3/5088 ,  C12N7/00 ,  C12N2795/10311 ,  C12N2795/10322 ,  C12N2799/00 ,  C12Q1/04 ,  C12Q1/6825 ,  C12Q1/689 ,  G01N33/48707 ,  G01N33/54373 ,  G01N33/56911

摘要： The present invention provides a method for detecting bacteria and a nano-well device having one or more input/output connections about a gap and one or more bacteriophages at or about the gap that trigger a detectable electrical field fluctuation when the one or more bacteriophages contact a cognate target within a liquid sample.

摘要翻译： 本发明提供了一种用于检测细菌的方法以及具有一个或多个围绕间隙的输入/输出连接以及一个或多个位于间隙处或附近的噬菌体的触发可检测的电场波动时的一个或多个噬菌体接触的纳米孔装置 液体样品中的同源目标。

公开(公告)号：EP1767215A1

公开(公告)日：2007-03-28

申请号：EP06024432.4

申请日：2001-06-12

申请人： The United States of America as represented by The Secretary, Department of Health and Human Services National Institutes of Health ,  Uniformed Services University of Health Sciences Department of Defense, United States Government

发明人： Landauer, Michael R. ,  Seed, Thomas Michael ,  Srinivasan, Venkataraman ,  Shapiro, Alla ,  Takimoto, Chris H.

IPC分类号： A61K41/00 ,  A61P43/00

CPC分类号： A61K31/352 ,  A23L33/105 ,  A23V2002/00 ,  A61K41/00 ,  A61K41/0038 ,  A23V2250/21172

摘要： The present invention provides compositions and methods for the prophylactic and therapeutic treatment of animals, including humans from radiation injury. In particular, the present invention provides methods and compositions comprising the isoflavone genistein (4', 5, 7-trihydroxyflavone) or phytoestrogenic isoflavonoids.

摘要翻译： 本发明提供了用于从放射性损伤预防和治疗动物（包括人）的组合物和方法。 特别地，本发明提供包含异黄酮染料木素（4'，5,7-三羟基黄酮）或植物雌激素异黄酮的方法和组合物。

公开(公告)号：EP1723429A1

公开(公告)日：2006-11-22

申请号：EP05729867.1

申请日：2005-03-07

申请人： The United States of America as represented by The Secretary, Department of Health and Human Services National Institutes of Health

发明人： CHO-CHUNG, Yoon, S.

IPC分类号： G01N33/574

CPC分类号： G01N33/574 ,  G01N2333/9121

摘要： The present invention relates to compositions and methods for the detection of anti-ECPKA autoantibodies in a biological sample, and to the use of such compositions and methods in the diagnosis of cancer in humans and non-human mammals.