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1.发明公开RADIOACTIVE SOURCE WIRE AND DUAL LUMEN CATHETER SYSTEM FOR BRACHYTHERAPY 审中-公开丝为近距离放疗放射源DOPPELLUMIGES导管系统
公开(公告)号：EP1331963A2
公开(公告)日：2003-08-06
申请号：EP01989959.0
申请日：2001-11-07
IPC分类号： A61M36/04
CPC分类号： A61N5/1002 , A61N2005/1025 , Y10T29/49801
摘要： A dual lumen catheter system for the positioning of a radioactive material for therapeutic radiation treatment of the body is disclosed. The radiation source wire (56) is tapered (50) at the distal end of the core wire.
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公开(公告)号：EP0210269A1
公开(公告)日：1987-02-04
申请号：EP86901576.0
申请日：1986-01-24
CPC分类号： G21G4/08 , A61N5/1027 , A61N2005/1023 , A61N2005/1024 , Y10S977/928
摘要： On produit des particules ou des "graines" (10) destinées à être implantées dans des tumeurs d'un corps humain dans le but de détruire les tumeurs, ou de les diminuer. Les graines contiennent du palladium (14) substantiellement enrichi en palladium-102 et activé par exposition à un flux de neutrons de manière à posséder une fraction mineure mais significative de palladium-103 qui émet des rayons X. Le palladium est distribué sur ou à tarvers un matériau de base pour réduire l'auto-blindage par le palladium. Les graines comportent un marqueur opaque aux rayons X (18) pour faciliter la visualisation des graines après leur implantation, le marqueur étant formé de préférence d'un matériau tel que le plomb ou le rhodium qui ne s'activent pas pour créer des isotopes non desirés dans les conditions d'irradiation dans lesquelles le palladium-102 est activé pour donner du palladium-103. Le palladium distribué sur ou à travers le matériau de base ainsi que le marqueur sont enfermés dans une coquillle allongée (22) formé par le soudage de deux capuchons d'extrémité (27) à un élément tubulaire (24), la construction de la coquille réduisant la masse de matière à l'extrémité de la graine, ce qui permet une distribution angulaire plus isotrope des rayons X.
摘要翻译： 产生颗粒或“种子”（10）用于植入人体肿瘤以达到破坏肿瘤或降低肿瘤的目的。 种子含有基本上富含钯-102的钯（14），并通过暴露于中子通量而被活化，以具有少量但显着部分的发射X射线的钯-103。钯分布在焦油 一种减少钯自身屏蔽的基本材料。 种子具有X射线不透明标记（18）以便于植入后对种子进行可视化，所述标记优选由诸如铅或铑的材料形成，所述材料不会产生非同位素。 在钯-102被活化而得到钯-103的照射条件下是期望的。 分布在基体材料上或通过基体材料和标记物的钯封装在通过将两个端盖（27）焊接到管状构件（24）而形成的细长壳体（22）中，壳体构造 减少种子末端的材料质量，允许X射线更加各向同性的角度分布。
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3.发明授权Apparatus for delivering insoluble material into a living body and method of use thereof 失效将不完全材料输送到生活体内的装置及其使用方法
公开(公告)号：EP0210875B1
公开(公告)日：1992-01-02
申请号：EP86305970.5
申请日：1986-08-01
IPC分类号： A61M36/00
CPC分类号： A61M5/1414 , A61M5/007 , A61M2005/1403 , A61N5/1007 , A61N2005/1021 , Y10S604/903
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4.发明公开
公开(公告)号：EP0210875A3
公开(公告)日：1987-08-19
申请号：EP86305970
申请日：1986-08-01
IPC分类号： A61M37/04
CPC分类号： A61M5/1414 , A61M5/007 , A61M2005/1403 , A61N5/1007 , A61N2005/1021 , Y10S604/903
摘要： To deliver a controlled dosage of an insoluble material into a living body, the material is provided in measured amounts in vials (12), and a system is provided forflushing the entire content of insoluble materials from the vial into the body. Insoluble radioactive material, such as glass microspheres incorporating radioactive isotopes, are packaged in a plurality of vials, preferably with different amounts of material. An accurate dosage of radioactivity can be delivered by administering the entire contents of one or more vial(s) according to the sum of radioactivity in selected vials as determined by the initial measurement of radioactivity and by the natural half-life of the isotope.
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公开(公告)号：EP1284778A1
公开(公告)日：2003-02-26
申请号：EP01935693.0
申请日：2001-05-18
发明人： BRAUCKMAN, Richard, A. , WHITE, Jack, C. , DILL, Glenn, A. , MOODY, Michael, R. , COON, Anthony, P.
IPC分类号： A61M29/00
CPC分类号： A61N5/1002 , A61N2005/1004
摘要： A catheter (12) for the positioning of a radioactive material (24) for therapeutic radiation treatment of the body is disclosed. The catheter includes a radioactive source (24) positioned at the distal end thereof and is sufficiently flexible and strong to navigate in the body to the desired treatment location. The radioactive source may be provided to the catheter in an number of different ways. In one set of embodiments, the radioactive source is bonded to the inner or outer surface of the catheter body (46), a catheter attachment (10) or a carrier positionable within the body.
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公开(公告)号：EP0793519A1
公开(公告)日：1997-09-10
申请号：EP95903585.0
申请日：1994-11-22
CPC分类号： A61N5/1027 , A61N2005/1024
摘要： Safe, isotopically pure Pd-103-containing seeds (10) of high apparent activity are formed by bombarding an Rh target in a cyclotron with high energy particles to obtain Rh containing carrier-free Pd-103, separating therefrom the carrier-free Pd-103, adding a small amount of Pd to the carrier-free Pd-103, electroplating said Pd-103/Pd admixture to a pellet(s) (14) of electroconductive material and encapsulating the pellet(s) (14) within a bi-compatible container or shell (22).
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公开(公告)号：EP1294306A1
公开(公告)日：2003-03-26
申请号：EP01941974.6
申请日：2001-06-05
IPC分类号： A61F2/00
CPC分类号： A61F2/92 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2250/0067
摘要： A stent (10) for insertion into a vessel of a body and used in connection with a foil sheet (12), wherein the foil sheet (12) comprises a radioactive material. The stent (10) and foil sheet (12) are positioned so that the radioactive material in the foil sheet (12) can deliver a desired dosage to a prescribed area, thereby reducing the distance for delivering the radioactive dose. The radioactive material may comprise carrier-free palladium (103). The foils screen (12) may further comprise a shielding lay (22) on one side for directing the dosage.
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公开(公告)号：EP0210269B1
公开(公告)日：1991-10-16
申请号：EP86901576.8
申请日：1986-01-24
IPC分类号： A61N5/10
CPC分类号： G21G4/08 , A61N5/1027 , A61N2005/1023 , A61N2005/1024 , Y10S977/928
摘要： Particles or "seeds" (10) are manufactured for implantation into tumours within a human body for emitting X-rays to destroy or reduce the tumours. The seeds contain palladium (14) which is substantially enriched in a palladium-102 and which is activated by exposure to neutron flux so as to contain a minor, but significant, fraction of X-ray emitting palladium-103. The palladium is distributed in or throughout a base material so as to reduce self-shielding by the palladium. The seeds include an X-ray-opaque marker (18) to facilitate external visualization of the seeds after their implantation, the marker preferably being formed of a material, such as lead or rhodium, which does not activate to contain undesirable isotopes under the radiation conditions in which palladium-102 is activated to palladium-103. The base material-distributed palladium and the marker are encased in an elongated shell (22) which is formed by welding a pair of end caps (27) to a tubular member (24), the construction of the shell reducing the mass of material at the end of the seed, thereby providing a more isotropic angular distribution of X-rays.
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9.发明公开Apparatus for delivering insoluble material into a living body and method of use thereof 失效装置，用于在活体中引入的不溶性物质并使用该设备。
公开(公告)号：EP0210875A2
公开(公告)日：1987-02-04
申请号：EP86305970.5
申请日：1986-08-01
IPC分类号： A61M36/00
CPC分类号： A61M5/1414 , A61M5/007 , A61M2005/1403 , A61N5/1007 , A61N2005/1021 , Y10S604/903
摘要： To deliver a controlled dosage of an insoluble material into a living body, the material is provided in measured amounts in vials (12), and a system is provided forflushing the entire content of insoluble materials from the vial into the body. Insoluble radioactive material, such as glass microspheres incorporating radioactive isotopes, are packaged in a plurality of vials, preferably with different amounts of material. An accurate dosage of radioactivity can be delivered by administering the entire contents of one or more vial(s) according to the sum of radioactivity in selected vials as determined by the initial measurement of radioactivity and by the natural half-life of the isotope.
摘要翻译： 为了提供一种不溶性材料的受控剂量到生物体内，该材料在测量的量提供在小瓶（12），并提供了一种用于冲洗不溶物从小瓶的全部内容到体内的系统。 不溶放射性材料，颜色：诸如玻璃微球掺入放射性同位素，被包装在小瓶的复数，优选用材料的不同的量。 放射性的精确剂量可通过在选定小瓶确定性通过放射性的初始测量开采施用一种或多种小瓶（S）雅丁到放射性的总和的全部内容，并通过同位素的天然半衰期来递送。
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公开(公告)号：EP1415149A2
公开(公告)日：2004-05-06
申请号：EP02752724.1
申请日：2002-08-07
IPC分类号： G01N33/00 , G01N23/223 , G08B13/18
CPC分类号： G01N24/08 , G01R33/441 , G07D7/14 , G07F7/086
摘要： The present invention relates to a method for associating information with an article (fig. 1), an isotopic labeling composition to label an article (15) with information using at least two different isotopes of an element, and an article labeled with the labeling composition. In the labeling composition, the isotopes of the labeling composition have an abundance ratio that is detectably different from the natural abundance ratio thereof. By detecting the abundance ratio(s) of the isotopes in the labeling composition, via laser ablation/magnetic spectroscopy, an NQR spectrometer (40), an NMR spectrometer (10), an IR spectrometer, or a microwave spectrometer, information about the article can be determined. The invention may be used to identify, authenticate or determine the source or origin of an article or to provide detailed information about an article.
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