公开(公告)号：EP3286339A2

公开(公告)日：2018-02-28

申请号：EP16784083

申请日：2016-04-25

申请人： UNIV OF IOWA RESEARCH FOUNDATION ,  THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS A BODY CORPORATE AND POLITIC OF THE STATE OF ILLINOIS

发明人： GIANGRANDE PALOMA H ,  MCNAMARA JAMES O ,  DICKEY DAVID D ,  OZER HOWARD ,  KRUSPE SVEN

IPC分类号： C12Q1/68 ,  G01N33/50

CPC分类号： C12Q1/68 ,  C12Q1/6816 ,  C12Q1/6886 ,  C12Q2525/117 ,  C12Q2525/125

摘要： The present invention relates to a rapid detection of circulating tumor cell (CTC)-associated nuclease activity with chemically modified nuclease substrate probes and compositions useful in detection assays.

公开(公告)号：EP3191593A4

公开(公告)日：2018-01-24

申请号：EP15840249

申请日：2015-09-08

申请人： UNIV OF IOWA RESEARCH FOUNDATION

发明人： AMENDT BRAD A ,  CAO HUOJUN

IPC分类号： C12N15/113 ,  C12N15/11 ,  C12N15/84 ,  C12N15/86

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N2310/113 ,  C12N2310/531 ,  C12N2330/51

摘要： The present invention relates to plasmid-based miR inhibitory systems (PMIS), miR inhibitors and methods of use of these systems and inhibitors.

公开(公告)号：EP3146051A4

公开(公告)日：2017-12-20

申请号：EP15795373

申请日：2015-05-20

申请人： UNIV OF IOWA RESEARCH FOUNDATION

发明人： DAVIDSON BEVERLY L ,  MAS MONTEYS ALEJANDRO

IPC分类号： C12N15/113 ,  A61K31/7088

CPC分类号： C12N15/113 ,  A61K9/0085 ,  A61K31/7088 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/30 ,  C12N2320/32 ,  C12N2330/51

摘要： The present invention is directed to RNA interference (RNAi) molecules targeted against a Huntington's disease nucleic acid sequence, and methods of using these RNAi molecules to treat Huntington's disease.

公开(公告)号：EP3065875A4

公开(公告)日：2018-02-07

申请号：EP14857438

申请日：2014-11-04

申请人： UNIV OF IOWA RESEARCH FOUNDATION

发明人： ZAVAZAVA NICHOLAS ,  ZHANG YAHUI ,  YU YIN ,  OZBOLAT IBRAHIM T ,  HONG LIU ,  CHEN HOWARD ,  SALEM ALIASGER K ,  MONCAL KAZIM KERIM ,  AKKOUCH ADIL

IPC分类号： B29C64/106 ,  B33Y10/00 ,  B33Y80/00

CPC分类号： B29C67/0055 ,  B29C64/106 ,  B29C64/386 ,  B29C64/40 ,  B29K2105/0061 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y80/00 ,  B41J3/407 ,  B41J3/543 ,  C09D11/04 ,  C09D11/102 ,  C09D11/30 ,  C09D11/38 ,  C12M21/08 ,  C12M33/00

摘要： A bioprinter and methods of using the bioprinter. The bioprinter permits selective three-dimensional movement of multiple nozzle assemblies during operation of the bioprinter. The bioprinter can be used to produce scaffold-free tissue constructs having a plurality of cellular elements interspersed among a semi-permeable vascular network. The bioprinter can also be used to print a tissue construct directly onto a tissue defect of a subject. The bioprinter can be provided as part of a bioprinting system that includes a scanner for imaging the tissue defect.