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    METHOD FOR IDENTIFYING RESPONSIVENESS TO FIBROBLAST GROWTH FACTOR RECEPTOR 1 INHIBITOR THERAPY
    2.
    发明公开
    METHOD FOR IDENTIFYING RESPONSIVENESS TO FIBROBLAST GROWTH FACTOR RECEPTOR 1 INHIBITOR THERAPY 审中-公开

    公开(公告)号：EP4134451A1

    公开(公告)日：2023-02-15

    申请号：EP21190726.6

    申请日：2021-08-11

    申请人： Universität zu Köln

    发明人： MALCHERS, Florian ,  THOMAS, Roman

    IPC分类号： C12Q1/6886

    摘要： The present invention pertains to a method for identifying a subject suffering from cancer as a responder or non-responder to fibroblast growth factor receptor 1 (FGFRi) inhibitor therapy. The method involves the determination of the presence or absence of a genetic alteration of the FGFR1 gene, wherein the genetic variation is a copy number variation caused by a Breakage-Fusion-Bridge-like (BFB-like) mechanism wherein the break is located within, or within close proximity of, the ORF of the FGFR1 gene. These breaks associate with FGFR inhibitor sensitivity, and intra-chromosomal tail-to-tail breaks in FGFR1 may work as a predictive therapeutic marker for an FGFR inhibitor therapy in cancer that can be used to stratify patients for FGFR-inhibitor therapy. Furthermore provided are inhibitors of FGFR1 for use in the treatment of cancer, and a method for identifying a genetic biomarker associated with a disorder, such as cancer.

    VECTOR AND METHOD FOR EXPRESSING MOLECULES OF INTEREST IN A BACTERIAL CELL
    8.
    发明授权
    VECTOR AND METHOD FOR EXPRESSING MOLECULES OF INTEREST IN A BACTERIAL CELL 有权

    公开(公告)号：EP3131919B1

    公开(公告)日：2018-10-10

    申请号：EP15717868.2

    申请日：2015-04-17

    申请人： Universität zu Köln

    发明人： CHMIELEWSKI, Markus ,  ABKEN, Hinrich

    IPC分类号： C07K14/245 ,  C12N15/62 ,  C12N15/70

    CPC分类号： C12N15/70 ,  C07K14/245 ,  C07K2319/00 ,  C12N15/62

    摘要： The present invention relates in a first aspect to a vector nucleic acid suitable for expressing at least one molecule of interest in a prokaryotic cell, in particular a bacterial cell, or on the surface of a prokaryotic cell or released by the prokaryotic cell. In particular, the present invention relates to a vector nucleic acid comprising a nucleic acid sequence encoding a Fim polypeptide. In addition, the present invention relates to a cell containing said vector as well as isolated recombinant protein containing at least a module being a Fim polypeptide and a module being a molecule of interest. In addition, the present invention relates to methods for the production of the molecule of interest using the vector nucleic acid according to the present invention. Finally, the present invention provides a kit of system containing said vector nucleic acid in particular for the production of recombinant molecule of interest.

    MEANS AND METHODS FOR DETECTING BETA-1,6-GLUCAN
    9.
    发明公开
    MEANS AND METHODS FOR DETECTING BETA-1,6-GLUCAN 审中-公开
    检测β-1,6-葡聚糖的手段和方法

    公开(公告)号：EP3279664A1

    公开(公告)日：2018-02-07

    申请号：EP16183098.9

    申请日：2016-08-05

    申请人： Universität zu Köln

    发明人： Zuccaro, Alga ,  Wawra, Stephan

    IPC分类号： G01N33/569

    CPC分类号： G01N33/56961 ,  G01N2333/37

    摘要： The present invention relates generally to the field of molecular biology and concerns a conjugate comprising a beta 1,6-glucan binding polypeptide, or a beta 1,6-glucan binding fragment thereof, and a detectable label. Moreover, also encompassed by the invention are a fragment of the beta 1,6-glucan binding polypeptide that specifically binds to beta 1,6 glucans, a vector comprising a nucleic acid encoding for the beta 1,6-glucan binding polypeptide and a host cell or non-human organism comprising a nucleic acid encoding for the beta 1,6-glucan binding polypeptide and the use of said conjugate comprising a beta 1,6-glucan binding polypeptide, or a beta 1,6-glucan binding fragment thereof.

    摘要翻译： 本发明一般涉及分子生物学领域，涉及包含β1,6-葡聚糖结合多肽或其β1,6-葡聚糖结合片段和可检测标记的缀合物。 此外，本发明还包括特异性结合β1,6葡聚糖的β1,6-葡聚糖结合多肽的片段，包含编码β1,6-葡聚糖结合多肽的核酸的载体和宿主 包含编码β1,6-葡聚糖结合多肽的核酸的细胞或非人生物体以及包含β1,6-葡聚糖结合多肽或其β1,6-葡聚糖结合片段的所述缀合物的用途。